Amulya Sreekumar

Why cancer can come back years later — and how to stop it Researchers are targeting dormant tumour cells that might explain why some cancers reappear long after successful treatment.

www.nature.com/articles/d41...

Mucin-type O-glycans regulate proteoglycan stability and chondrocyte maturation O -glycosylation is a ubiquitous post-translational modification essential for protein stability, cell signaling, and tissue organization, yet how distinct O -glycan subclasses coordinate tissue devel...

🚀New pre-print from the lab, led by PhD candidate Xiaolin Dong! www.biorxiv.org/content/10.6...

In this study, we uncovered crosstalk between mucin-type O-glycans and HSPGs, showing that truncated O-GalNAc glycans destabilize proteoglycans, impair FGF signaling, & disrupt chondrogenesis. #glycotime

Current Job Offers - BIH at Charité Current Job Offers - Berliner Institut für Gesundheitsforschung - Charité und Max-Delbrück-Centrum

🚀 BIH is recruiting for its PhD Program! Work on cutting-edge translational projects spanning immunotherapy, genomics, AI, hematopoiesis, precision medicine & more.
Apply by Jan 19, 2026.
🔗 Join us in turning research into health! www.bihealth.org/en/career/wo...

Fascinating study (and thread) about the role of cytoplasmic MLH1 in residual tumor cells that go on to seed ER+ breast cancer recurrences

Thank you, Svasti! ♥️

Thank you, Julio!

Check our new venture into drug discovery #glycotime!

Targeting dormant tumor cells to prevent recurrent breast cancer: a randomized phase 2 trial - Nature Medicine A combination of mouse model data and data from a randomized phase 2 trial in patients with breast cancer in remission demonstrates feasibility, safety and a reduction in residual tumor cells followin...

Comprehensive experiments in pre-clinical models and clinical data analysis demonstrate that dormancy creates a unique window of opportunity to deplete minimal residual disease and delay recurrence. Congratulations to all the authors on this important body of work!

Ångström-resolution imaging of cell-surface glycans - Nature Nanotechnology By combining bioorthogonal metabolic labelling and resolution enhancement through sequential imaging of DNA barcodes, the molecular organization of individual sugars in the native glycocalyx has been ...

New paper online:

Ångström-resolution imaging of cell-surface glycans.

The molecular organization of sugars in the native #glycocalyx has been resolved at 9 ångström using bioorthogonal metabolic labeling and #superresolution imaging of DNA barcodes.

#Glycotime

www.nature.com/articles/s41...

World central kitchen has been doing great work consistently. Every meal counts. Donate here.

donate.wck.org/give/525879/...

Congratulations!! 🥂

As a budding scientist, the idea that form follows function led me to a career studying developmental biology and how these principles are distorted in cancer. Excited to share this preprint reporting a surprising transdifferentiation of breast cancer cells unlocked by dormancy. Link below:

AACR Legislative Action Center Directly contact your elected officials about the importance of cancer research, the need for continued funding and the latest lifesaving breakthroughs. In the United States, you can do so by sending ...

Kudos to the @theaacr.bsky.social for making it easy to reach out to your representatives. Nice to see courage and action. nam02.safelinks.protection.outlook.com?url=https%3A...

Live imaging of the extracellular matrix with a glycan-binding fluorophore - Nature Methods Rhobo6 is a cell-impermeable small-molecule fluorophore that displays reversible fluorogenic binding to glycans, making it a general, wash-free, and non-perturbative label for the extracellular matrix...

Check it out, powerful new method for optical imaging of the live ECM, from @hhmijanelia.bsky.social Group Leader Kayvon Pedram #proudofalumni #glycotime

www.nature.com/articles/s41...

Done!

Pathway to independence: a new initiative supporting postdocs on the job market

Apply for our Pathway to Independence programme, a scheme supporting postdocs going on the job market in 2025 with training, mentorship, profile-raising and networking opportunities. Apply by 31 Jan 2025: https://buff.ly/3VJGgDC

#aECM (apical extracellular matrix) is a subset of #ECMatrix that is distinct from stromal matrices or basement membranes. Anybody out there studying #mucins #ZPproteins #cuticle #glycocalyx #surfactant or the like? We need to find each other and start talking!

Done!

Of course!

The secret is out! 🚀 Thrilled to support Valora's mission to bring our #AbLec technology to patients, alongside co-inventor @carolynbertozzi.bsky.social. More to come, and in the meantime, you can learn more about AbLecs here:
www.biorxiv.org/content/10.1...

Done!

Pls share 🌟Join the IMP as a Group Leader
We are 👀 for a colleague, ready to lead a groundbreaking research program. Enjoy generous funding, outstanding facilities & a vibrant scientific community in one of the world's most livable cities @impvienna.bsky.social
👉https://tinyurl.com/impgl2025

Modulation of AAV9 Galactose Binding Yields Novel Gene Therapy Vectors and Predicts Cross-Species Differences in Glycan Avidity - PubMed Effective use of adeno-associated viruses (AAVs) for clinical gene therapy is limited by their propensity to accumulate in and transduce the liver. This natural liver tropism is associated with severe...

Ever wondered how gene therapies know where to go? Screening AAV vector libraries across different species I uncovered evidence of altered #glycan profiles between mouse, NHP and human liver, with implications for translation of #AAV #genetherapy

pubmed.ncbi.nlm.nih.gov/39001819/

Enjoy!

Done! Nice seeing you here Lance

Of course! You're on the list

Done!

Done!

Thanks, Manuel! You're in the pack.

Done!

B3GALT6 promotes dormant breast cancer cell survival and recurrence by enabling heparan sulfate-mediated FGF signaling Sreekumar et al. identify a previously uncharacterized function for the galactosyltransferase B3galt6 in cancer, specifically enabling dormant residual tumor cell survival following therapy or in a re...

Thank you to the organizers of #SFG2024 for hosting a wonderful meeting @sfglycobiology.bsky.social

As a 1st time attendee, it was a privilege to present my work on B3galt6-heparan sulfate biosynthesis as a functional regulator of dormant breast cancer cell survival.

www.cell.com/cancer-cell/...