Alberto Elosegui-Artola

Beautiful work! Congrats Maria and team!

🚨 New paper from our lab just published in Nature🚨

www.nature.com/articles/s41...

Discover how 🌱 tumour formation is shaped by tissue context from the very beginning. Cancer is not driven by genetics alone

✨Fantastic team led by Greta Skrupskelyte, Eduardo Rojo, @hariajith.bsky.social

Postdoctoral clinical fellows Opportunities for postdoctoral clinicians to consolidate their research experience.

Are you a clinician looking for a fully-funded postdoctoral research opportunity?

Check out our postdoctoral career development fellowships for clinicians, and see how you can join our vibrant community: www.crick.ac.uk/careers-and-...

Join us!

We are #Hiring! Our lab is looking for a LabTech/Lab Manager! Take a look to our research here!
physics-of-life.tu-dresden.de/team/pol-gro...
Drop a line if you are interested to know more details!
#labtech #labtechnician #biology #labtechnicians #labmanager #labwork #Xenopus #zebrafish #devbiol

Abstract deadline looming! Coming join us in June for a great meeting on developmental origins of paediatric cancers, including neuroblastoma organised by @tsakiridis.bsky.social and friends @childrenwithcancer.bsky.social #neuralcrest www.crick.ac.uk/whats-on/dev...

Join us at SMBE26! We are in a golden period for understanding the evolution of gene regulation.

Paper alert! β-catenin forms condensates that help build cell–cell adhesions - showing its role goes beyond simply linking E-cadherin to α-cat/actin. Great collaboration with the Schuijers lab!

👉 nature.com/articles/s41...

Modelling co-development between the somites and neural tube in human trunk-like structures - Nature Cell Biology Makwana, Tilley et al. generate human stem cell-based trunk-like structures approximating Carnegie stage 13–14 of development. They use them to model and study the development of the thoracic and lumbar trunk.

Lovely little pre-Christmas present to see this out @natcellbio.nature.com! Some 🔥 new results in here since the biorvix incl (1) a new RARE-GFP reporter ✳️🙌, (2) additional NMP quantification 🔢, (3) no neural tube patterning on RA inhibition 🙅 etc. Enjoy! 😍 www.nature.com/articles/s41...

SPIN90 modulates the architecture of lamellipodial actin in an ARPC5L dependent fashion. When stimulated by nucleation-promoting factors such as WAVE, the Arp2/3 complex generates branched actin networks. In contrast, when activated by SPIN90, the Arp2/3 complex generates linear actin fil...

SPIN90 and #YanCao strike again! First NPF to only activate a subset of Arp2/3 iso-complexes to regulate lamellipodial actin & protrusion efficiency. Great collaboration with @romet-jegou-lab.bsky.social #ManosMavrakis polarized fluorescence microscopy rocks 🤘💥🎉
www.biorxiv.org/content/10.6...

Combinatorial BMP4 and activin direct the choice between alternate routes to endoderm in a stem cell model of human gastrulation Inge et al. show that human endoderm originates from two converging developmental routes with distinct dynamics and efficiencies yet similar developmental potential. Combinatorial activin and BMP4 sig...

So exciting to see this in print! Ever wondered how embryonic cells know what (fate) to become during early development? In particular when they might see different signaling cues? We investigated this!

And a lovely cover from Zoe Ruiz and @oliveringe.bsky.social!

www.cell.com/developmenta...

If you are interested in an interdisciplinary project connecting tissue mechanics, synthetic approaches and dev bio, this is the position for you! we are excited to get this colaboration started!!👇👇🤩🤓👇👇

Background of DNA strand with logos of King's College London and the Leverhulme Trust and text Coping with mechanical stress: tissue dynamics during development, homeostasis and repair Professor Yanlan Mao University College London Force Talks Mechanics of Life Leverhulme DSP seminar series

Our next #ForceTalk is Prof Yanlan Mao @yanlanmao.bsky.social on "Coping with mechanical stress: tissue dynamics during development, homeostasis and repair"

🗓️ 26 Nov 2025
🕒 15:00 - 16:00 GMT

Online & open to all 👉 www.kcl.ac.uk/events/force-talk-yanlan-mao

#mechanobiology @kingsnmes.bsky.social

Very happy to share the beautiful cover of @cp-trendscancer.bsky.social that is designed based on our review article on #platelets and their role, usage and targeting in #cancer and its #therapy

Link to the full issue : www.cell.com/issue/S2405-...

@inserm.fr @unistra.fr

I am happy to announce that my group has an opening for a funded PhD position to explore the intersection between mechanobiology and inflammation in the intestine. Please see the attached advertisement below. Thanks for circulating and forwarding!

www.srcsb.uni-stuttgart.de/news/New-ope...

Congratulations Elias!

Spatially organized cellular communities shape functional tissue architecture in the pancreas Spatial maps reveal dynamic epithelial-mesenchymal niches shaping pancreatic development and function.

🚨 Check out our new paper is now online in its final version!!!
🎉 👏 Congratulations @alejotorrescano.bsky.social who led the study
+ past & current team @labspagnoli.bsky.social
+ collaborators #VigilanteLab @kingslsm.bsky.social

➡️ doi.org/10.1126/scia...

short 🧵 below & more acknowledgments ⤵️

How weakness in cell structure affects the host-microbiome relationship Mice lacking a gene responsible for cell structure lose intestinal balance and experience systemic inflammation, mirroring a lethal condition seen in humans.

Researchers at the Crick have discovered that mice lacking a specific gene responsible for cell structure lose intestinal balance and experience systemic inflammation, mirroring a lethal condition seen in humans.

www.crick.ac.uk/news/2025-11...

This research was led by @luiz90vasc.bsky.social and Shaina Chor Mei Huang with corresponding author @drmichaelway.bsky.social

1/ 🎉Excited to share our new preprint @vignjeviclab.bsky.social @davidbrueckner.bsky.social :

"Self-organization of tumor heterogeneity and plasticity"
biorxiv.org/content/10.1...

Tumor heterogeneity and plasticity drive metastasis and relapse. How is tumor patterning coordinated?

A thread👇

📣Announcing the 4th edition of the EMBL‑IBEC Conference on “Engineering Multicellular Systems”, taking place 11–13 March 2026 in Barcelona. Exploring organoids, mechanobiology, embryo models, organ-on-chip systems, multiomics and more. Abstracts open now!
events.ibecbarcelona.eu/embl-ibec-co...

Tomorrow at @ISTAresearch.bsky.social in Vienna at 4:30 PM I will show and discuss how shapes can emerge (and disappear) from mixture of microtubules and molecular motors.
#morphogenesis

Integrin‐Piezo1 Axis Drives ECM Remodeling and Invasion of 3D Breast Epithelium Mechanical stiffening of the extracellular matrix around mature mammary acini induces sequential remodeling phases. An early response disrupts the basement membrane and promotes fibronectin secretion...

🚨Excited to share our new paper where we find that in situ ECM stiffening of mature mammary acini induces BM loss, FN deposition & invasion through α3β1/α5β1–FAK→Piezo1 axis—linking integrin switching to MSCs and epithelial remodelling. Led by the amazing Kabilan Sakthivel
tinyurl.com/stnczkc6

The Francis Crick Institute PhD programme recruitment is now live and our lab is recruiting. If you are interested in studying the role of the extracellular matrix in tissue dynamics during development and cancer please apply – link below. Please share. www.crick.ac.uk/careers-stud...

Targeting AMPK as a metabolic vulnerability of metastatic cancer cells Targeting AMPK as a metabolic vulnerability of metastatic cancer cells

We are offering a super exciting project to develop new ways of targeting metastatic cancer cells!
Amazing supervisory team:
Primary supervisor: Professor Joanna Loizou
Associate supervisor: Professor Zoran Rankovic
Secondary supervisor: Professor Victoria Sanz-Moreno
@icr.ac.uk

Phd oportunity

Looking for a PhD for 2026? We have 2 projects in collaboration with Clare Bennett (UCL) looking at macrophage metabolism in breast cancer. Check them out! @cruk-cityoflondon.bsky.social

www.colcc.ac.uk/2026-phd-pro...

crukradnet.colcc.ac.uk/phd-students...

🔬Speakers:
1-Caren Norden @nordenlab.bsky.social and @carldmodes.bsky.social
2-@nicolettapetridou.bsky.social and @zenahadjivasiliou.bsky.social
3-@yonitmms.bsky.social and Marko Popović
4.-Vasudha Srivastava and Asa Kalish
|A huge thank you to all the speakers. 2/2

Don’t miss the exciting ISSCR Webinar: Integrating Biophysics into Stem Cell Biology next Tuesday October 14!
The webinar features paired tandem talks that brings together experimentalists and theorists working at the interface of stem cell biology and biophysics. 1/2
www.isscr.org/upcoming-pro...

The Francis Crick Institute PhD programme recruitment is now live and our lab is recruiting. If you are interested in studying the role of the extracellular matrix in tissue dynamics during development and cancer please apply – link below. Please share. www.crick.ac.uk/careers-stud...

Are you interested on how regenerating tissues transit between stages? Am sharing here our work showing that during #Xenopus tail regeneration, tissue stiffening activates a Piezo1-Yap1 mechanosensitive cascade to allow wounded epithelia to transit into regenerative states!