Gerard Lab

HIF-1α+ CD4+ T cells coordinate a tissue-resident immune cell network in the lung A deeper understanding of how tissue-localized immune cells arise and function is critical for developing mucosal vaccines. Currently, there are no mu…

New paper out: HIF-1α+ CD4+ T cells coordinate a tissue-resident immune cell network in the lung
www.sciencedirect.com/science/arti...

Murine T-cell receptor OT-I exhibits imperfect discrimination between foreign and self-antigens - The EMBO Journal T cells use their T-cell receptors (TCRs) to discriminate between higher-affinity foreign and lower-affinity self-peptide-MHC (pMHC) antigen complexes. The OT-I mouse TCR is widely used to study antig...

I always struggled to find the OT-I TCR affinity values for the OVA peptide and altered peptides. Here are the updated Kd values!
link.springer.com/article/10.1...

Our work accurately measuring the 3D affinity between the OT-I TCR and a large number of foreign and self antigen ligands is now published at EMBO Journal.

Murine T-cell receptor OT-I exhibits imperfect discrimination between foreign and self-antigens
www.embopress.org/doi/full/10....

Murine T-cell receptor OT-I exhibits imperfect discrimination between foreign and self-antigens
Omer Dushek @tcell.bsky.social and colleagues show that 3D solution affinities of the OT-I TCR for foreign and self-antigens predict functional T-cell responses
www.embopress.org/doi/full/10....

For our #flowcytometry peeps, would you like to have a single fix/perm protocol that is optimised for everything? One that preserves fluorophores while allowing simultaneous TF and cytokine staining? How about 100-fold cheaper?

You got it:
currentprotocols.onlinelibrary.wiley.com/doi/10.1002/...

Lung structural cells are altered by influenza virus leading to rapid immune protection following re-challenge @natcomms.nature.com www.nature.com/articles/s41...

Defining the genetic determinants of CD8+ T cell receptor repertoire in the context of immune checkpoint blockade Immune checkpoint blockade influences the genetically determined relationship between TCR repertoire and HLA alleles in cancer.

📣First paper from the lab is out in @science.org‬! 📣https://www.science.org/doi/10.1126/sciadv.adu3461 It’s well known that HLA shapes the TCR repertoire — but how does this change under immune checkpoint blockade (ICB)?

Dr Fränze Progatzky wins Lister Prize Dr Fränze Progatzky, Principal Investigator in Tissue Biology and Wellcome Career Development Fellow, has been awarded a Lister Institute Research Prize to support her outstanding science.

Congratulations to Dr Fränze Progatzky, who has been awarded a Lister Institute Research Prize to support her research into glial cell biology!

www.kennedy.ox.ac.uk/news/dr-fran...

@thelisterinstitute.bsky.social @franzeprogatzky.bsky.social

I'm excited about a new @biorxivpreprint.bsky.social story that just went live! This one takes a #computational #immunology approach to understanding #tissueresident lymphocytes. The story highlights the extra value mathematical modelling can bring to biology. 🧵1/10

www.biorxiv.org/content/10.1...

Subclonal immune evasion in non-small cell lung cancer Dijkstra et al. investigate whether individual cancer subclones differ in their immune evasion capacity. They establish organoids representing distinct subclones from multi-region lung cancer biopsies...

Subclonal immune evasion in non-small cell lung cancer: Cancer Cell www.cell.com/cancer-cell/...

Our new review article led by Jordan Kramer:

Platforms for studying cell–cell recognition by immune cells

onlinelibrary.wiley.com/doi/10.1111/...

Dear uLIPSTIC users,

We have been getting reports that, under some more inflammatory settings like TB or chronic LCMV infection, uLIPSTIC-expressing lymphocytes adoptively transferred into cre-negative uLIPSTIC hosts may be rejected at later timepoints (>1 wk).

There are still a few places left for this major @oxfordcancer.bsky.social fixture. We are keeping registration open until places are filled so sign up now!

Model figure - in EAC cancers, as chromosomal instability (CIN) increases, we found that a CIN-driven cGAS-dependent axis drives myeloid directed chemokine expression and recruitment of tumor-favoring myeloid populations

Incoming - new preprint alert from the Parkes lab led by @brunobeernaert.bsky.social Full bluetutorial follows! 1/ 11 www.biorxiv.org/content/10.1...

Macrophages direct location-dependent recall of B cell memory to vaccination Vaccines generate long-lived plasma cells and memory B cells (Bmems) that may re-enter secondary germinal centers (GCs) to further mutate their B cell…

Happy #DayofImmunology! Congrats @ramadhenni.bsky.social & Alexandra Carey Hoppé it's out (finally!) @cp-cell.bsky.social! Incredibly grateful to co-leads @mlmunier.bsky.social, Vanessa Venturi & Tony Kelleher & all brilliant folks @garvaninstitute.bsky.social & Kirby Inst. for fantastic collab! 🧵

CMV serostatus is associated with improved survival and delayed toxicity onset following anti-PD-1 checkpoint blockade - Nature Medicine Analysis of multiple cohorts of patients with melanoma demonstrates a positive association between cytomegalovirus serostatus and overall survival in patients treated with monotherapy but not combinat...

www.nature.com/articles/s41...
Proud of my group and collaborators for this work published today in Nature Medicine. We find Cytomegalovirus, which has a profound impact on T cell immunity, is associated with distinct clinical outcomes in patients receiving checkpoint immunotherapy for melanoma.

DPhil in Cancer Science We use cookies to ensure that we give you the best experience on our website. If you click 'Accept all cookies' we'll assume that you are happy to receive all cookies and you won't see this message…

Last chance to apply for our 2025 DPhil in Cancer Science Programme!

🥼 We are open to applications from Medical Undergraduates

📚 We also have 3 GSK-Oxford DPhil studentships available.

📢 Deadline: Noon 25th April.

Apply below ⬇️ @medsci.ox.ac.uk

www.cancer.ox.ac.uk/study#how-to...

Now published @cp-iscience.bsky.social
Work lead by David Lecky & Lozan Sheriff in collaboration with @therad-lab.bsky.social and @cameron-wraith.bsky.social showing how IFNg augments T Cell receptor signal strength to enhance type 1 Regulatory T (Tr1) cell development

www.cell.com/iscience/ful...

A computational pipeline for spatial mechano-transcriptomics - Nature Methods The authors present a computational framework that leverages mechanical force inference and spatial transcriptomics to enable analyses of the interplay between the transcriptomic and mechanical state.

🚨 Paper Alert 🚨
Absolutely delighted to share our last paper on "spatial mechano-transcriptomics" @naturemethods👇!!
www.nature.com/articles/s41...

TBK1 and IKKε prevent premature cell death by limiting the activity of both RIPK1 and NLRP3 death pathways TBK1 and IKKe prevent premature cell death by limiting the activity of multiple death pathways in myeloid cells.

The loss of TBK1, or both TBK1 and the related kinase IKKε, results in uncontrolled cell death–driven inflammation. We show that TBK1/IKKε prevent premature cell death by limiting the activity of multiple death pathways in myeloid cells. www.science.org/doi/10.1126/...

Cecelia: a multifunctional image analysis toolbox for decoding spatial cellular interactions and behaviour Nature Communications - Integrated solutions for the analysis of complex 3D and live cell images remain scarce. Here, the authors present Cecelia, an image analysis toolbox based on R and Python,...

I need to try this!
rdcu.be/ebfVl

Adaptive immunity in barrier tissues Immune responses lie at the heart of almost every aspect of human health, including host responses to infection, autoimmunity, cancer, metabolism and aging. While adaptive immune responses by B and T…

🦠🔬 We are very excited to organize an EMBO workshop on Immunity in Barrier Tissues with Carolyn King! @immunologyking.bsky.social

📍 Where: Basel, Switzerland
📅 When: 26th–29th August 2025
📝 Registration deadline: 30th May 2025

Check out the program and details 🔗

#EMBOBarrierTissues @embo.org

Research Assistant (177885) We are looking for a Research Assistant with a background in immunology/neurobiology to join the interdisciplinary laboratory of Dr Fränze Progatzky at the Kennedy Institute.

🚨 We have TWO exciting open positions in our lab! 🚨

We are looking for talented, highly motivated, and collaborative individuals to join our dynamic team as:

🔬 Research Assistant
www.kennedy.ox.ac.uk/jobs/researc...

💻 Bioinformatics Postdoc
www.kennedy.ox.ac.uk/jobs/bioinfo...

📢 Please share!

Intravital imaging of pulmonary lymphatics in inflammation and metastatic cancer @jem.org @simoncleary.bsky.social
doi.org/10.1084/jem....

Oxford and GSK launch £50million immuno-prevention programme to advance novel cancer research Global biopharma company GSK invests up to £50 million in a collaboration with Oxford to advance the understanding of how cancer develops, which could inform future development of vaccines to prevent ...

www.cancer.ox.ac.uk/news/oxford-...

Meningeal regulatory T cells restrain local interferon-γ–producing lymphocytes, thereby safeguarding parenchymal brain homeostasis
@sciimmunology.bsky.social @mmr2.bsky.social
www.science.org/doi/10.1126/...

Tissue-resident memory CD8 T cell diversity is spatiotemporally imprinted - Nature Profiling of the location and transcriptome of tissue-resident memory CD8 T cell formation at single-transcript resolution finds regionalized signalling as the basis of immune diversity in t...

It turns out the immune system is playing 4D chess while we thought it was just playing checkers. Using #spatialtranscriptomics from @10xgenomics.bsky.social and @vizgen.bsky.social we were able to peek into the secret lives of tissue resident T cells in the gut as they form after infection 1/n

The OT-I TCR is often criticised as being very high-affinity and displaying unusual behaviour compared to other TCR transgenics. New work from @tcell.bsky.social shows this might not be the case. Will I still use OT-I and all the wonderful tools associated with it? Yes I will!

MuSpAn: A Toolbox for Multiscale Spatial Analysis The generation of spatial data in biology has been transformed by multiplex imaging and spatial-omics technologies, such as single cell spatial transcriptomics. These approaches permit a detailed mapp...

FYI for anyone interested in MuSpAn - we've updated the preprint this week with the full SI. Now featuring more examples of how various different spatial metrics can be strung together in order to make spatial pipelines focussed on specific biological questions!

www.biorxiv.org/content/10.1...

Two studies published in @nature.com today showing that Tpex-like cells develop independent from acute or chronic infection

#Tpex

www.nature.com/articles/s41...