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Casey Theriot

@theriotmicrobe

Professor in Infectious Disease, microbiologist, C. difficile, gut microbiome, metabolomics, microbial mediated bile acids, amino acids

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10.10.2023
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Latest posts by Casey Theriot @theriotmicrobe

KSQA: Drs. Joseph P. Zackular & Mariana X. Byndloss (Beyond Antibiotics)
KSQA: Drs. Joseph P. Zackular & Mariana X. Byndloss (Beyond Antibiotics) YouTube video by KeystoneSymposia

⏰ Last chance to save $250! Register for Beyond Antibiotics by 11:59pm MST on March 5.

Join @joeyzacks.bsky.social, @kimingeneva.bsky.social, @dariavantyne.bsky.social & @maribyndloss.bsky.social to spark new collaborations.

πŸŽ₯ youtu.be/8Ppjx-MnvxA
keysym.us/KSBeyondAnti...

#KSBeyondAntibiotics26

27.02.2026 16:30 πŸ‘ 4 πŸ” 5 πŸ’¬ 1 πŸ“Œ 1
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Mucosal vaccination clears Clostridioides difficile colonization - Nature Mucosal administration of a multivalent, adjuvanted vaccine against Clostridioides difficile promoted bacterial clearance and protected against morbidity, mortality, tissue damage and recurrence ...

#NatMicroPicks

C. diff vaccine! πŸ¦ πŸ’‰

A protective mucosal vaccine formulation that provides sterilizing immunity to clear C. difficile from the host.

#MicroSky

www.nature.com/articles/s41...

22.02.2026 06:44 πŸ‘ 54 πŸ” 11 πŸ’¬ 0 πŸ“Œ 7
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How a Better Bile Acid Could Keep C. diff at Bay

news.cvm.ncsu.edu/how-a-better...

16.12.2025 15:39 πŸ‘ 6 πŸ” 1 πŸ’¬ 1 πŸ“Œ 0
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A Mouse Model of C. diff at NC State is Helping Scientists Around the World Develop Better Antibiotics

Some nice press from a recent international collaboration with researchers from Leiden University.
news.cvm.ncsu.edu/a-mouse-mode...

12.12.2025 15:47 πŸ‘ 9 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

Nearly 1,000 people have registered so far! Don't miss out!

10.12.2025 23:26 πŸ‘ 7 πŸ” 2 πŸ’¬ 0 πŸ“Œ 0

Really fun collaboration with Roman Melnyk from The Hospital for Sick Children Research Institute and Peter Dosa from University of Minnesota, making synthetic bile acids to be gut-restricted prevents C. difficile infection in a preclinical mouse model

18.11.2025 14:26 πŸ‘ 19 πŸ” 7 πŸ’¬ 0 πŸ“Œ 0
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Structure-guided design of a synthetic bile acid that inhibits Clostridioides difficile TcdB toxin - Nature Microbiology A bile acid-bound structure of toxin TcdB revealed the mechanism of inhibition and guided the design of a synthetic bile acid that alleviated Clostridioides difficile infection in mice.

#NewResearch

A bile acid-bound structure of toxin TcdB revealed the mechanism of inhibition and guided the design of a synthetic bile acid that alleviated C. difficile infection in mice.

#MicroSky πŸ¦ πŸ’Š

www.nature.com/articles/s41...

18.11.2025 14:07 πŸ‘ 36 πŸ” 17 πŸ’¬ 0 πŸ“Œ 2
Successful Fecal Microbiota Transplants in Post-antibiotic Treated Recurrent Clostridioides difficile Patients Induce Acylcarnitine and Sphingolipid Lipidomic Shifts Clostridioides difficile infection (CDI) is an urgent public health threat in the United States, resulting on an annual basis in over half a million cases, more than 29,000 deaths, and $4.8 billion in...

Really nice work driven by postdocs Dr. Gancz in my lab and Dr. Zhang in Baker @erinbakerims.bsky.social lab at UNC, looking at novel lipids and how they might play a role in restoring colonization resistance against C. difficile in patients with rCDI post FMT.
www.researchsquare.com/article/rs-7...

03.11.2025 13:29 πŸ‘ 3 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0
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Leids β€˜superantibioticum’ houdt met lage dosis gevaarlijke darmbacterie in bedwang Het in Leiden ontwikkelde antibioticum EVG7 slaagt erin om met een minimale dosis de gevaarlijke darmbacterie C. difficile te bestrijden. Bovendien komt de bacterie minder gemakkelijk terug, wat bij b...

Leids β€˜superantibioticum’ houdt met lage dosis gevaarlijke darmbacterie in bedwang www.universiteitleiden.nl/nieuws/2025/...

13.10.2025 14:31 πŸ‘ 2 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0
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Experimental glycopeptide antibiotic EVG7 prevents recurrent Clostridioides difficile infection by sparing members of the Lachnospiraceae family - Nature Communications Treatment of Clostridioides difficile infections (CDI) with vancomycin is associated with high relapse rates. In this study, the experimental glycopeptide antibiotic EVG7 was found to effectively treat CDI without relapse in a murine model of recurrent CDI.

New paper alert! In this work, published in @natcomms.nature.com we show that a new antibiotic is effective against (r)CDI. www.nature.com/articles/s41...

11.10.2025 14:19 πŸ‘ 11 πŸ” 5 πŸ’¬ 1 πŸ“Œ 0
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Experimental glycopeptide antibiotic EVG7 prevents recurrent Clostridioides difficile infection by sparing members of the Lachnospiraceae family - Nature Communications Treatment of Clostridioides difficile infections (CDI) with vancomycin is associated with high relapse rates. In this study, the experimental glycopeptide antibiotic EVG7 was found to effectively treat CDI without relapse in a murine model of recurrent CDI.

Really nice collaboration with the Martin and Smits labs at Leiden University Netherlands, designing and testing novel antimicrobials that target C. difficile but spare members of the microbiota, including Lachnospiraceae.
www.nature.com/articles/s41...

10.10.2025 12:14 πŸ‘ 4 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
About Seeding Postdoctoral Innovators in Research & Education (SPIRE)

SPIRE’s Mission:

1) To provide scholars with both high quality research training and the opportunity to develop research based teaching skills that will inspire students across the sciences

2) To promote effective teaching and research partnerships between research intensive institutions and partner institutions with a large population of underrepresented students

The four major components of the SPIRE Postdoctoral Fellowship Program include:

Research
Teaching
Professional Development
Additional Opportunities

About Seeding Postdoctoral Innovators in Research & Education (SPIRE) SPIRE’s Mission: 1) To provide scholars with both high quality research training and the opportunity to develop research based teaching skills that will inspire students across the sciences 2) To promote effective teaching and research partnerships between research intensive institutions and partner institutions with a large population of underrepresented students The four major components of the SPIRE Postdoctoral Fellowship Program include: Research Teaching Professional Development Additional Opportunities

Cool Postdoc opportunity alert! UNC SPIRE (Seeding Postdoctoral Innovators in Research & Education)-it provides scholars with both high quality research training & the opportunity to develop research based teaching skills that will inspire students across the sciences 1/n
spire.unc.edu/program-info/

01.10.2025 14:31 πŸ‘ 16 πŸ” 23 πŸ’¬ 1 πŸ“Œ 1
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NIH whistleblower details clash over childhood vaccines with Trump administration: "We became inconvenient" A former NIH official says she was removed after clashes over vaccines, accusing RFK Jr. and his deputies of posing "a substantial and specific danger to public health and safety."

"We became inconvenient".

09.09.2025 12:01 πŸ‘ 0 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0

If you believe that keeping your head down and being quiet will spare you from this fate, you are mistaken. This will be all of us.

24.08.2025 15:39 πŸ‘ 499 πŸ” 171 πŸ’¬ 3 πŸ“Œ 1
Department members sit at a very long table in the hallway eating a pre-Thanksgiving potluck feast.

Department members sit at a very long table in the hallway eating a pre-Thanksgiving potluck feast.

Faculty search announcement 2025: Tenure-Track Assistant Professor in Microbiology at UT Southwestern. We seek candidates working in microbial pathogenesis (some preference may be given to bacterial pathogens). Come join our community! (1/5) www.utsouthwestern.edu/departments/...

18.08.2025 14:31 πŸ‘ 60 πŸ” 100 πŸ’¬ 3 πŸ“Œ 4

The best of both worlds with awesome speakers that will focus on how the microbiome affects ecosystems at a mechanistic level. Can’t wait for this meeting.

12.08.2025 23:35 πŸ‘ 12 πŸ” 2 πŸ’¬ 0 πŸ“Œ 0
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A federal agency - which controls an enormous amount of money - is breaking the law to hide its decisions from you and avoid accountability.

Hey OMB, see you in court.

29.07.2025 18:22 πŸ‘ 442 πŸ” 149 πŸ’¬ 17 πŸ“Œ 28
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I have thought on it and prayed about it, and I have decided: I am running to be the next U.S. Senator from North Carolina.

28.07.2025 12:05 πŸ‘ 9127 πŸ” 1781 πŸ’¬ 570 πŸ“Œ 601

Thank you Senator Tillis! NC folks drop him an email or make a call and thank him

26.07.2025 20:44 πŸ‘ 17 πŸ” 5 πŸ’¬ 0 πŸ“Œ 0

We’ve known for months now that Vought was illegally impounding funds with the goals of rescissions. Better late than never for GOP Senators to politely ask that he stop breaking the law.

26.07.2025 00:29 πŸ‘ 450 πŸ” 121 πŸ’¬ 11 πŸ“Œ 5

Enterococcus faecalis modulates phase variation in Clostridioides difficile https://www.biorxiv.org/content/10.1101/2025.07.24.666506v1

25.07.2025 04:18 πŸ‘ 13 πŸ” 7 πŸ’¬ 1 πŸ“Œ 2

I am so excited about this meeting. I will cover the discovery of 10,000s new metabolites, including an entirely new class of molecules. Looking forward to hearing and discussing your science on microbiome metabolites and metabolism.

21.07.2025 16:54 πŸ‘ 31 πŸ” 7 πŸ’¬ 0 πŸ“Œ 0
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Probiotics Can Help or Hinder Gut Recovery After Antibiotic Treatment

New paper is out from our lab showing that some probiotics can accelerate and prolong the return of colonization resistance to C. difficile after antibiotics.
news.ncsu.edu/2025/07/prob...

21.07.2025 16:52 πŸ‘ 20 πŸ” 8 πŸ’¬ 1 πŸ“Œ 1
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Join us in Banff, CAN January 19-22 for the Keystone meeting on Microbiome Metabolism and Metabolites! Early scholarship deadline is September 23!

18.07.2025 13:08 πŸ‘ 3 πŸ” 2 πŸ’¬ 1 πŸ“Œ 0
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100+ UNC research projects lose federal funding UNC-Chapel Hill is navigating a significant $126 million reduction in federal grant funding compared to last fiscal year.

Thanks to WRAL for documenting the tremendous impact of the Trump administration efforts to end important research grants
www.wral.com/news/local/u...

27.06.2025 14:34 πŸ‘ 8 πŸ” 2 πŸ’¬ 0 πŸ“Œ 1
PostDoc Research Fellow - Gut Microbiology - Theriot Lab A postdoctoral scientist position (1+ years) is available in Prof. Casey Theriot’s group at North Carolina State University College of Veterinary Medicine (NCSU CVM).Duties and ResponsibilitiesThe suc...

We are looking for a new postdoctoral fellow to join our team at NC State University College of Veterinary Medicine, near Research Triangle Park. If you are interested please DM me and or also apply here: jobs.ncsu.edu/postings/219...

17.06.2025 14:00 πŸ‘ 5 πŸ” 4 πŸ’¬ 0 πŸ“Œ 0
Economic loss due to NIH budget cuts by congressional district, scienceimpacts.org/fy26

Economic loss due to NIH budget cuts by congressional district, scienceimpacts.org/fy26

The #SCIMaP team announces a major update: an analysis of the economic impacts of the White House's NIH FY26 budget.

Bottom-line, we estimate $46B in total economic loss, 202K lost jobs, and impacts in communities nationwide.

Interactive map and shareable report:
scienceimpacts.org/fy26

a 🧡

23.06.2025 19:10 πŸ‘ 623 πŸ” 411 πŸ’¬ 25 πŸ“Œ 61
PostDoc Research Fellow - Gut Microbiology - Theriot Lab A postdoctoral scientist position (1+ years) is available in Prof. Casey Theriot’s group at North Carolina State University College of Veterinary Medicine (NCSU CVM).Duties and ResponsibilitiesThe suc...

We are looking for a new postdoctoral fellow to join our team at NC State University College of Veterinary Medicine, near Research Triangle Park. If you are interested please DM me and or also apply here: jobs.ncsu.edu/postings/219...

17.06.2025 14:00 πŸ‘ 5 πŸ” 4 πŸ’¬ 0 πŸ“Œ 0

Incredible work, JP!

#McClintockLetters

16.06.2025 18:41 πŸ‘ 8 πŸ” 6 πŸ’¬ 0 πŸ“Œ 0
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The microbiome diversifies long- to short-chain fatty acid-derived N-acyl lipids Mass spectrometry data mining tools enabled the creation of an MS/MS spectral library containing hundreds of N-acyl lipids, including conjugates with short-chain fatty acids. This resource enabled the...

If you have ever wondered what might happen to short chain fatty acids made by the microbiome. Here is a large class of metabolites and how they link to biology. www.cell.com/cell/fulltex...

12.06.2025 17:56 πŸ‘ 93 πŸ” 41 πŸ’¬ 2 πŸ“Œ 3