Pavel Moudrý

Truly delighted to host @agagambus.bsky.social next week in Brno for an IBP Guest Lecture! Her groundbreaking work and genuinely human approach to science have always been a great inspiration to me. Come and join us for her lecture at IBP 👇

The need for speed: drivers and consequences of accelerated replication forks - Communications Biology A mini review explores molecular drivers of replication fork acceleration and their consequences for genome stability, innate immunity, and cancer.

A mini review explores the molecular drivers of replication fork acceleration and their consequences for genome stability, innate immunity, and cancer. @3reak.bsky.social

www.nature.com/articles/s42...

A nuclease-driven mechanism of post-replicative ssDNA gap suppression. The persistence of post-replicative ssDNA gaps following PRIMPOL-mediated replication repriming is linked to chemosensitivity, and in all models reported to date the nuclease MRE11 has been implicated...

New preprint from the lab for any DNA repair or replication stress geeks out there!

www.biorxiv.org/content/10.1...

Postdoctoral Research Associate in the Blackford Group A position as Postdoctoral Research Associate is available at the Department of Cellular and Molecular Medicine, in the group headed by Dr. Andrew Blackford. Th

We’re #hiring, please share! A fully funded #postdoc position is available in my lab to work on DNA damage response mechanisms.

Please get in touch with your CV if you are interested; closing date: 27th June 2025.

More details here: candidate.hr-manager.net/ApplicationI...

Sharing our latest work tracking DNA damage inheritance by Live+QIBC www.nature.com/articles/s41.... Huge congrats to @apanagopoulos.bsky.social, M. Stout and all co-authors for this tour de force! Beautifully summarized by @s-j-aitken.bsky.social & E. Reilly www.nature.com/articles/d41...

PhD pozice ve výzkumu replikace DNA Ve výzkumné skupině DNA replication dynamics na Ústavu molekulární a translační medicíny Lékařské fakulty Univerzity Palackého v Olomouci nabízíme pozici pro PhD studenta. Disertační práce na téma …

🧬 Zbývá už jen poslední měsíc na přihlášení na PhD pozici zaměřenou na výzkum replikace DNA. Přidej se k našemu týmu a podílej se na špičkovém biomedicínském výzkumu!
📍Ústav Molekulární a Translační Medicíny, UPOL Olomouc
📅 Deadline: 15.5.2025
www.researchjobs.cz/job/phd-pozi...

Our new preprint is now on bioRxiv! 📄 We introduce qAID, an AI-based workflow for automated analysis of DNA replication dynamics. Glad to have contributed a small part to this study.

📢 For all DNA fiber enthusiasts! 🟥🟩 We are thrilled to announce the release of our long-awaited AI-based workflow for the automated and quantitative analysis of DNA fibers. It's an exciting step forward—check it out on bioRxiv! lnkd.in/dQWUPtsP

PAF15-PCNA assembly exhaustion governs lagging strand replication and replisome integrity Genome replication in eukaryotic cells is surveyed by the S-phase checkpoint, which orchestrates sequential replication origin activation to avoid exhaustion of hitherto poorly defined rate-limiting r...

Thrilled to share our lab's first preprint, led by an exceptional PhD student Gita Chhetri and with the support of wonderful collaborators, we find that replisome function is rate-limited by strand-specific PCNA dynamics. Hope you will enjoy reading.

www.biorxiv.org/content/10.1...

Brief teaser:

For all of you who cannot access pubmed, here is a good alternative:
europepmc.org