@mmrrc
An NIH-funded consortium, providing a national repository for genetically engineered mouse strains and embryonic stem cell lines. Researchers worldwide can access these high-quality, well-characterized mouse models to advance studies.
Advances in organ and computer models are raising the prospect that some animal experiments could be eliminated. But there are still huge hurdles to overcome. Read More Here: https://postly.click/5vU
The research landscape is approaching a turning point. Proposed cuts would weaken science—especially physiology—that drives medical breakthroughs. This overview sets the stage for a deeper look at what’s at stake and why this full report matters: https://www.physio
Scientists, with initial mouse models findings, expand results in organoids to confirm nerve-repair treatment can trigger healing in human spinal tissue. Source: https://www.sciencealert.com/scientists-grew-mini-human-spinal-cords-then-made-them-repair-after-injury
🫱A new polymer delivery system may allow insulin to be absorbed through the skin and control blood sugar without injections, at least in animal studies! Source: https://www.nature.com/articles/s41586-025-09729-x
In vivo & in silico: Compounds linked to traditional medicine reduced anxiety-, depression-, and pain-related behaviors in mice. Computer modeling suggested key compounds and targets, while mouse studies showed how those predictions played out biologically: https://doi.org/10.100
Turning Back Immune System Aging: A new method instructs liver to pump out specific proteins, effectively hitting the "reset" button on an aging immune system to restore youthful defense capabilities. Source: www.livescience.com/health/immun...
📖 To celebrate the holidays, we've taken some of our strains to compose a seasonal story. Written version is below. Or spoken version here: youtu.be/xl-pHB0Y5bc . For the full "cast" see this link: postly.click/s61
National Security Commission on Emerging Biotechnology warns U.S. science is getting outpaced: https://www.fiercebiotech.com/biotech/us-commission-recommends-federal-research-revamp-avoid-losing-global-biotech-edge?utm_medium=email&utm_source=nl&utm_campaign=LS-NL-FierceBiotechResearch&oly_enc
Scientists found that HSL not only breaks down fat but also works inside the nucleus of to keep adipose tissue healthy, explaining why people lacking HSL lose fat instead of becoming obese. https://scitechdaily.com/obesity-discovery-
The research landscape is approaching a turning point. Proposed cuts would weaken science—especially physiology—that drives medical breakthroughs. This overview sets the stage for a deeper look at what’s at stake and why this full report matters: https://www.physio
The FDA has approved Kygevvi (doxecitine + doxribtimine) as the first-ever treatment for Thymidine Kinase 2 Deficiency (TK2d), offering hope to patients with this devastating mitochondrial disease. https://www.fda.gov/drugs/news-events-human-drugs/fda-approves-1st-
Scientists have made major progress in understanding and treating thymidine kinase 2 deficiency (TK2d), a rare genetic disorder that weakens muscles by disrupting mitochondrial DNA maintenance. https://postly.click/ABY
James D. Watson, part of the team that uncovered the double-helix structure of DNA in 1953 with Francis Crick, Rosalind Franklin and Maurice Wilkins, has died at 97. His work marked a notable moment in biology.
https://www.yahoo.com/news/articles/james-watson-co-discoverer-double-1957www.yahoo.com/n
As oocytes grow, H2A.Z shifts from marking active genes to spreading across broader, silent DNA regions, working hand-in-hand with another modification to support healthy meiosis and prepare the egg’s epigenetic blueprint for early embryonic life. .nature.com/articles/s41594-025-01573-xMore Info:
IMPC Strategic Conference
‘Insights from the Past, Shaping the Future’
Program and key information
👉 https://www.mousephenotype.org/news/2025-virtual-impc-conference-registration-and-agenda/
Free Registration
👉https://tinyurl.com/yz7znkde
🎉 Big congrats to Dr. Eric Green for receiving the American Society of Human Genetics Leadership Award — a standing ovation for visionary leadership in genomics! Read About it here: https://www.genengnews.com/topics/omics/eric-green-receives-ashg-leadership-award-to-standing-ovation/
"Animal models provide insights that alternative approaches can’t. A heated debate about which method is better is distracting researchers from doing good science."
https://EcKc5wILd4%3D
MMRRC is in Boston at ASHG for the next 3 days - booth 1327! For more info: https://meetings.ashg.org/event/ASHG25/program/schedule
What Baby KJ’s CRISPR Breakthrough Really Tells Us. Reflections on the balance between hope and realism — new therapies are exciting, but they’re not universal cures yet. Read More: https://www.statnews.com/2025/10/09/crispr-cure-baby-kj-rare-diseases-personalized-gene-editing-drugs/?_hsmi=38470699
Congratulations to Drs. Brunkow, Ramsdell, & Sakaguchi! For More information: https://postly.click/ECH
“...the first step out of the maze for young men begins by reasserting to them the virtue of hard work — an often grueling but indispensable part of finding the right answers in science.”
Read the essay with our gift article here: www.nytimes.com/2025/10/03/o...
Some good research "food for thought... " https://www.nature.com/articles/d41586-025-02920-0?utm_source=Live+Audience&utm_campaign=b2c87a0562-nature-briefing-daily-20250916&utm_medium=email&utm_term=0_-33f35e09ea-49915704
🌟 We’re proud to support the Rare Diseases Are Not Rare! Challenge—working together for faster treatments.
With over 10,000 rare diseases, collaboration is key to speeding discovery and care. Learn more: https://www.challenge.gov/?challenge=rare-diseases-are-not-rare-2025-challenge
We're taking efforts to improve the information of new strains at the MMRRC, with our new Strain Quality Control. To view an example of one, visit this strain: https://www.mmrrc.org/catalog/sds.php?mmrrc_id=75745#gene_info_Strain_Quality_Control
" Read more here: https://www.genengnews.com/topics/translational-medicine/why-we-still-need-animal-research-in-a-world-of-ai-and-organoids/
"To be clear, there is no replacement yet for animal research in biomedical science...it remains to be seen how faithfully these [stem cell] reprogrammed cells and organoids mimic various complex biological processes.
Mice treated with a copper drug repaired faulty brain proteins, reversing Parkinson’s symptoms and offering new hope. Source: https://www.goodnewsnetwork.org/scientists-reverse-parkinsons-symptoms-in-mice-we-were-astonished-by-the-success/
What happens when lifesaving research quietly disappears? A look at critical NIH-funded projects lost to sudden budget cuts: projects.propublica.org/nih-cuts-res...
Imagine a future where the smell of menthol could alleviate some of the worst symptoms of Alzheimer’s disease. Read More: https://theconversation.com/when-mice-with-alzheimers-inhaled-menthol-their-cognitive-abilities-improved-230330
Scientists used gene-edited mice to test a custom therapy for a deadly infant liver disease—then saved a real child! (P.S., A MMRRC Center Director is an author on this paper!) Source: www.nejm.org/doi/full/10....
