Velindre Library

Episode 184: RS3PE A WIFI password from the 90's or an actual toxicity Final Part

Post-St David's Day blues? Have another Welshcake and listen to the new Immunobuddies - Episode 184: RS3PE A WIFI password from the 90's or an actual toxicity Final Part. @velindrecc.bsky.social @rickyfrazer1.bsky.social open.spotify.com/episode/0PYE...

NICE Technology Appraisal Guideline [TA1138]: Durvalumab with gemcitabine and cisplatin for neoadjuvant treatment then alone for adjuvant treatment of muscle-invasive #BladderCancer. www.nice.org.uk/guidance/ta1...

Choosing Wisely recommendations in oncology: a scoping review - Supportive Care in Cancer Choosing Wisely (CW) campaign addresses the global challenge of reducing waste in healthcare by discouraging unnecessary interventions, minimizing harm, and promoting evidence-based care. Barriers lik...

Choosing Wisely recommendations in oncology: a scoping review. link.springer.com/article/10.1...

The diagnostic accuracy of soft tissue oedema measurements: a systematic review and best-evidence synthesis - Supportive Care in Cancer Purpose Effective lymphoedema management relies on early detection and treatment during its reversible phase, underlining the importance of accurate measurement tools. This systematic review aims to i...

The diagnostic accuracy of soft tissue oedema measurements: a systematic review and best-evidence synthesis. link.springer.com/article/10.1...

Neoadjuvant GOLP in Resectable High-Risk Intrahepatic Cholangiocarcinoma | NEJM No neoadjuvant treatment has been considered to be standard therapy for patients with resectable intrahepatic cholangiocarcinoma with high-risk factors for recurrence. The GOLP regimen (gemcitabine...

Neoadjuvant GOLP in Resectable High-Risk Intrahepatic Cholangiocarcinoma. www.nejm.org/doi/full/10....

Upadacitinib for Immune Checkpoint Inhibitor–Related Dermatitis This nonrandomized clinical trial examines the safety and efficacy of oral upadacitinib in the treatment of patients with severe immune checkpoint inhibitor–related dermatitis.

Upadacitinib for Immune Checkpoint Inhibitor–Related Dermatitis: A Nonrandomized Clinical Trial. jamanetwork.com/journals/jam...

Outcomes of Older Adults With Advanced Cancer Who Prefer Quality of Life vs Prolonging Survival This secondary analysis of a randomized clinical trial explores treatment outcome preferences among older adults with advanced cancer, specifically whether survival or quality of life matters most to ...

Outcomes of Older Adults With Advanced #Cancer Who Prefer Quality of Life vs Prolonging Survival: A Secondary Analysis of the GAP70+ Cluster Randomized Clinical Trial. jamanetwork.com/journals/jam...

Phase I/II clinical trial of a melanoma vaccine targeting shared non-mutated antigens and a shared mutated BRAF neoantigen with an agonistic CD40 antibody (CDX-1140) plus TLR3 agonist (poly-ICLC) Background For patients with high-risk melanoma who are unresponsive or intolerant to immune checkpoint inhibitors, cancer vaccines may provide benefit with a favorable toxicity profile. CD4 + T cells...

Phase I/II clinical trial of a melanoma vaccine targeting shared non-mutated antigens and a shared mutated BRAF neoantigen with an agonistic CD40 antibody (CDX-1140) plus TLR3 agonist (poly-ICLC). jitc.bmj.com/content/14/3...

Nivolumab ± Ipilimumab in Patients With Pretreated Advanced Neuroendocrine Carcinoma: The GCO-001 NIPINEC Randomized Phase II Trial. ascopubs.org/doi/10.1200/...

Phase II Clinical Study of Adebrelimab and Bevacizumab Combined With Cisplatin/Carboplatin in Patients With Triple-Negative Breast Cancer With Brain Metastases (ABC Study) PURPOSEBrain metastases (BMs) of triple-negative breast cancer (TNBC) are lethal, often associated with a limited life span and lack of effective antitumor agents. Here we reported a triple combinatio...

Phase II Clinical Study of Adebrelimab and Bevacizumab Combined With Cisplatin/Carboplatin in Patients With Triple-Negative #BreastCancer With Brain Metastases (ABC Study). ascopubs.org/doi/10.1200/...

Imlunestrant plus abemaciclib versus fulvestrant plus abemaciclib in ER-positive, HER2-negative advanced breast cancer: an indirect treatment comparison of three phase III trials The EMBER-3 trial demonstrated significant progression-free survival (PFS) benefit for imlunestrant + abemaciclib versus imlunestrant alone in patients with estrogen receptor (ER)-positive/human epide...

Imlunestrant plus abemaciclib versus fulvestrant plus abemaciclib in ER-positive, HER2-negative advanced #BreastCancer: an indirect treatment comparison of three phase III trials. www.esmoopen.com/article/S205...

Quality-of-life outcomes with pimitespib in patients with advanced gastrointestinal stromal tumor: results from the randomized, double-blind, placebo-controlled, phase III, CHAPTER-GIST-301 study Health-related quality of life (HRQoL) has emerged as an important outcome following the introduction of tyrosine kinase inhibitors for metastatic gastrointestinal stromal tumors (GISTs). We report th...

Quality-of-life outcomes with pimitespib in patients with advanced gastrointestinal stromal tumor: results from the randomized, double-blind, placebo-controlled, phase III, CHAPTER-GIST-301 study. www.esmoopen.com/article/S205...

A confidence-based, artificial intelligence pathology model for diagnosis of intrahepatic cholangiocarcinoma Intrahepatic cholangiocarcinoma (ICCA) is a rare but highly lethal adenocarcinoma arising within the hepatic parenchyma. Diagnosis presents a significant clinical challenge as the histological feature...

A confidence-based, artificial intelligence pathology model for diagnosis of intrahepatic cholangiocarcinoma. www.annalsofoncology.org/article/S092...

Osimertinib plus datopotamab deruxtecan in patients with EGFR-mutated advanced NSCLC post-progression on first-line osimertinib: ORCHARD ORCHARD (NCT03944772) was a phase II platform study conducted to characterize resistance mechanisms and evaluate novel treatment combinations following progressive disease (PD) on first-line osimertin...

Osimertinib plus datopotamab deruxtecan in patients with EGFR-mutated advanced NSCLC post-progression on first-line osimertinib: ORCHARD. www.annalsofoncology.org/article/S092...

Nivolumab plus ipilimumab versus sunitinib for first-line treatment of advanced renal cell carcinoma: final analysis of efficacy and safety from the phase III CheckMate 214 trial Nivolumab plus ipilimumab (NIVO+IPI) demonstrated significant long-term survival and response benefits in patients with previously untreated advanced renal cell carcinoma (aRCC) in the phase III Check...

Nivolumab plus ipilimumab versus sunitinib for first-line treatment of advanced renal cell carcinoma: final analysis of efficacy and safety from the phase III CheckMate 214 trial. www.annalsofoncology.org/article/S092...

5-year results of hypofractionated locoregional radiotherapy in early breast cancer HypoG-01 (UNICANCER): a French multicentre, randomised, non-inferiority, phase 3, open-label, controlled trial 3-week radiotherapy (40 Gy in 15 fractions) was found to be non-inferior to 5-week radiotherapy (50 Gy in 25 fractions) for arm lymphoedema risk and was comparably safe regarding other late normal tis...

5-year results of hypofractionated locoregional radiotherapy in early #BreastCancer HypoG-01 (UNICANCER): a French multicentre, randomised, non-inferiority, phase 3, open-label, controlled trial. www.thelancet.com/journals/lan...

Pimicotinib versus placebo for tenosynovial giant cell tumour (MANEUVER): an international, randomised, placebo-controlled, phase 3 trial Pimicotinib showed robust antitumour activity with clinically meaningful improvements in TGCT-related functional limitations and symptom burden, offering an effective treatment option with a manageabl...

Pimicotinib versus placebo for tenosynovial giant cell tumour (MANEUVER): an international, randomised, placebo-controlled, phase 3 trial. www.thelancet.com/journals/lan...

CBCT-guided pencil beam scanning Proton therapy for Moving lung tumors- PROMO Study: Standardized workflow & early outcomes from a consecutive real-world cohort. www.clinicaloncologyonline.net/article/S093...

Reducing Variation in Palliative Treatment for Oesophago-Gastric #Cancer: Insights from the National Oesophago-Gastric Cancer Audit. www.clinicaloncologyonline.net/article/S093...

Complications post gastrostomy insertion in patients with head and neck #Cancer : A Systematic Review. www.clinicaloncologyonline.net/article/S093...

Neoadjuvant sacituzumab govitecan plus pembrolizumab, followed by adjuvant pembrolizumab, in patients with muscle-invasive bladder cancer (SURE-02): a single-arm, phase 2 study Perioperative sacituzumab govitecan plus pembrolizumab revealed a promising clinical complete response rate, without the occurrence of grade 4 or higher adverse events, allowing a bladder preservation...

Neoadjuvant sacituzumab govitecan plus pembrolizumab, followed by adjuvant pembrolizumab, in patients with muscle-invasive #BladderCancer (SURE-02): a single-arm, phase 2 study. www.thelancet.com/journals/lan...

Episode: 183 RS3PE A WIFI password from the 90's or an actual toxicity Part 3

It's Wear Red Day, it's stopped raining for a bit and... there's new Immunobuddies! Episode: 183 RS3PE A WIFI password from the 90's or an actual toxicity Part 3. @velindrecc.bsky.social @rickyfrazer1.bsky.social open.spotify.com/episode/2Cv2...

The National Audit of Metastatic Breast Cancer (NAoMe): Sharing Key Findings and Recommendations From the 2025 State of the Nation Report

The National Audit of Metastatic #BreastCancer (NAoMe): Sharing Key Findings and Recommendations From the 2025 State of the Nation Report. www.clinicaloncologyonline.net/article/S093...

The National Non-Hodgkin Lymphoma Audit: Insights and Impact. www.clinicaloncologyonline.net/article/S093...

NICE Technology Appraisal Guideline [TA1136]: Bevacizumab (originator and biosimilars) with fluoropyrimidine-based chemotherapy for metastatic colorectal #cancer www.nice.org.uk/guidance/ta1...

Aspirin and other nonsteroidal anti‐inflammatory drugs (NSAIDs) for preventing colorectal cancer and colorectal adenoma in the general population - Cai, Z - 2026 | Cochrane Library Select your preferred language for Cochrane reviews and other content. Sections without translation will be in English.

Aspirin and other nonsteroidal anti‐inflammatory drugs (NSAIDs) for preventing colorectal #cancer and colorectal adenoma in the general population www.cochranelibrary.com/cdsr/doi/10....

PACE-NODES: A phase III randomised trial of 5 fraction prostate stereotactic body radiotherapy (SBRT) versus 5 fraction prostate and pelvic nodal SBRT In 2020, there were an estimated 1.4 million new prostate cancer cases and 375,000 deaths worldwide[12]. Within the UK, the National Prostate Cancer Audit reports 14,560 of the 56,144 (26%) men diagno...

PACE-NODES: A phase III randomised trial of 5 fraction prostate stereotactic body radiotherapy (SBRT) versus 5 fraction prostate and pelvic nodal SBRT @velindrecc.bsky.social www.ctro.science/article/S240...

MRI in advanced ovarian cancer: multicentre MISSION trial. For patients with advanced ovarian cancer, complete cytoreductive surgery (CRS) offers the best chance for long-term survival and cure. Currently, staging relies on CT and, in selected cases, diagnost...

MRI in advanced ovarian #cancer: multicentre MISSION trial. www.ejcancer.com/article/S095...

Real-world outcomes of immunotherapy discontinuation at two years in advanced non-small cell #LungCancer: Final results of the I-STOP study. www.clinicalkey.com#!/content/jo...

Artificial intelligence model for cardiovascular disease risk prediction in breast cancer patients using electronic health records and computed tomography scans Cardiovascular disease (CVD) is a group of conditions affecting the heart and blood vessels. The World Health Organization reports that in 2019, a third of global deaths (17.9 mil) were due to heart d...

Artificial intelligence model for cardiovascular disease risk prediction in #breastcancer patients using electronic health records and computed tomography scans www.thegreenjournal.com/article/S016...