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Matt Healy

@matthewdhealy

Techbio, Virology, Drug Discovery, Data, Midwest, Engineering, NLP, science, theology, history of science https://orcid.org/0000-0001-6439-5038

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19.11.2024
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Latest posts by Matt Healy @matthewdhealy

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Virginia passes legislation prohibiting schools from teaching falsehoods about Jan. 6 riot The bill passed by the Virginia legislature prohibits schools from teaching what it considers to be falsehoods about the U.S. Capitol riot, including portraying it "as peaceful protest."

Virginia passes law to prevent schools from telling Trump’s lies about January 6th rioters

www.cbsnews.com/news/virgini...

07.03.2026 19:15 πŸ‘ 0 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

As for taste and texture, homogenization has more impact than pasteurization. Later this morning I will purchase some locally made 1% milk that is pasteurized for safety but not homogenized; the label says "Shake, Shake, Shake."

07.03.2026 15:23 πŸ‘ 0 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

The treatment is designed to reduce harmful microbes. And there are dairy products DESIGNED to be safe ways to get probiotics, like yogurt.

07.03.2026 15:23 πŸ‘ 0 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0

I have no desire to meet harmful bacteria. And raw milk fans' understanding of pasteurization is deeply wrong: pasteurized milk is NOT sterile, it is somewhat probiotic.

07.03.2026 15:23 πŸ‘ 0 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0

The Surgeon General nominee "wants to meet the cow" from which her raw milk came.

07.03.2026 15:23 πŸ‘ 0 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0
Collage of three charts about U.S. job growth by presidential administration.
Top left: bar chart titled β€œAnnual change, non-farm employment” (from Wikipedia) showing average yearly job growth for presidents from Franklin Roosevelt through Joe Biden. Most Democratic administrations show higher growth rates than Republican ones.
Top right: chart titled β€œJob Growth Is Greater Under Democratic Presidents” (source: Joint Economic Committee, Bureau of Labor Statistics) showing total job gains since 1981: Reagan ~16.1 million, George H. W. Bush ~2.6 million, Clinton ~22.9 million, George W. Bush ~1.4 million, Obama ~11.6 million, Trump –2.7 million, Biden ~16.2 million so far.
Bottom left: New York Times chart of monthly job changes since 2023 showing fluctuations with a recent monthly loss of about 92,000 jobs in February.
Caption text on the right summarizes: for nearly a century, by job growth and most major macroeconomic measures, the U.S. economy has generally performed better when a Democrat occupies the White House.

Collage of three charts about U.S. job growth by presidential administration. Top left: bar chart titled β€œAnnual change, non-farm employment” (from Wikipedia) showing average yearly job growth for presidents from Franklin Roosevelt through Joe Biden. Most Democratic administrations show higher growth rates than Republican ones. Top right: chart titled β€œJob Growth Is Greater Under Democratic Presidents” (source: Joint Economic Committee, Bureau of Labor Statistics) showing total job gains since 1981: Reagan ~16.1 million, George H. W. Bush ~2.6 million, Clinton ~22.9 million, George W. Bush ~1.4 million, Obama ~11.6 million, Trump –2.7 million, Biden ~16.2 million so far. Bottom left: New York Times chart of monthly job changes since 2023 showing fluctuations with a recent monthly loss of about 92,000 jobs in February. Caption text on the right summarizes: for nearly a century, by job growth and most major macroeconomic measures, the U.S. economy has generally performed better when a Democrat occupies the White House.

07.03.2026 15:13 πŸ‘ 0 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

Has been pretty vindicating that the people on Twitter we used to argue with about COVID actually got their chance to run things and they each turned out to be every bit the incompetent fuckwit that we knew they’d be

07.03.2026 00:17 πŸ‘ 315 πŸ” 44 πŸ’¬ 1 πŸ“Œ 0

people that hate cats are so funny to me because the things they complain about also are complaints autistic people hear about themselves β€œunfriendly” β€œunapproachable” β€œmean” etc

meanwhile the cats and the autistics are just minding our business and not seeking validation from someone

06.03.2026 17:07 πŸ‘ 1651 πŸ” 195 πŸ’¬ 3 πŸ“Œ 0

The Economist model estimates the peak was nearly 4,000 excess deaths in the US per day in late December 2020, and nearly as high for much of January 2021.

I don't think ANY of the GBD crowd has admitted to having been horribly wrong about the pandemic.

07.03.2026 03:48 πŸ‘ 33 πŸ” 4 πŸ’¬ 0 πŸ“Œ 1
Preview
Google Has a Secret Reference Desk. Here's How to Use It. 40 Google features to find exactly what you need, the alternative search engines that do things Google won't, and the reference desk framework underneath all of it.

Some great Google search tips for better research

cardcatalogforlife.substack.com/p/google-has...

07.03.2026 00:52 πŸ‘ 0 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

it's ALMOST like maybe there are good reasons to be encouraging electrification or something!

and maybe there are many of those reasons!

06.03.2026 20:31 πŸ‘ 155 πŸ” 6 πŸ’¬ 2 πŸ“Œ 0

I didn't think when I wrote

"Additionally, because oil deposits inevitably run dry, we often rely on extraction efforts happening in other countries which may or may not be friendly.... and [its] cost can change quite dramatically based on supply and demand"

it would be so prescient but, well...

06.03.2026 20:29 πŸ‘ 1250 πŸ” 84 πŸ’¬ 24 πŸ“Œ 1
Screenshot of a New York Times article titled β€œIs This Treadmill Walking Trend Good for Your Fitness?” with the subheading β€œHere’s what to know about the 12-3-30 workout.” On the right side of the screen is my reader comment, which explains that adjusting the slope of a treadmill is a useful way to vary workout intensity because speed changes tend to force shifts between different gaits (walking, jogging, running), each with distinct biomechanics optimized for specific speeds. Incline changes, by contrast, allow smoother adjustment of effort while staying within the comfortable walking range. The comment notes that I learned this principle in graduate school from Duke Professors Steven Vogel and Stephen Wainwright, leaders in comparative biomechanics.

Screenshot of a New York Times article titled β€œIs This Treadmill Walking Trend Good for Your Fitness?” with the subheading β€œHere’s what to know about the 12-3-30 workout.” On the right side of the screen is my reader comment, which explains that adjusting the slope of a treadmill is a useful way to vary workout intensity because speed changes tend to force shifts between different gaits (walking, jogging, running), each with distinct biomechanics optimized for specific speeds. Incline changes, by contrast, allow smoother adjustment of effort while staying within the comfortable walking range. The comment notes that I learned this principle in graduate school from Duke Professors Steven Vogel and Stephen Wainwright, leaders in comparative biomechanics.

06.03.2026 21:06 πŸ‘ 0 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

Some writers and researchers have turned up in the Files simply because somebody in Epstein's circle emailed one of their articles, so I checked whether any of my publications were there. Seems like none have; I guess his crowd doesn't care about Computational Biology & Genomics analytical tools.

06.03.2026 20:08 πŸ‘ 0 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
Preview
Sex, Lies, and the Epstein Files The new files fill in what I was missing at the time.

Many reputations have been besmirched by the Epstein Files.

Tina Brown's reputation has been enhanced: she was one of the very few prominent voices trying to tell the world how awful he was before most of us even knew his name.

tinabrown.substack.com/p/sex-lies-a...

06.03.2026 20:01 πŸ‘ 0 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0
Alan Beattie in the Financial Times:

"The competing economic superpower offers are now as follows. From the US you get forced into trade deals promising a future of burning fossil fuels whose price is subject to wildly destructive US adventurism. From China you get reliably cheap EVs and green tech to generate renewables."

Alan Beattie in the Financial Times: "The competing economic superpower offers are now as follows. From the US you get forced into trade deals promising a future of burning fossil fuels whose price is subject to wildly destructive US adventurism. From China you get reliably cheap EVs and green tech to generate renewables."

06.03.2026 14:06 πŸ‘ 0 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
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More fun with the eclipse. This is an image of the moon before the eclipse (8:50 PM PST) and one at mid-eclipse. Both used the same imaging equipment. The first was taken with a 1/8000s exposure, the second is a stack of 20, 0.8s exposures. You can see some libration (rotation). #astrophotography

05.03.2026 17:22 πŸ‘ 249 πŸ” 33 πŸ’¬ 1 πŸ“Œ 2

I ain't got noembody
Noembody cares for me
Noembody
Noembody

I'm so sad and lonely
Won't some Lewandowski
Come take a chance with me
'Cause I ain't so bad

05.03.2026 21:18 πŸ‘ 828 πŸ” 41 πŸ’¬ 44 πŸ“Œ 3
A small moment of scientific gratification.

Many years ago I was part of a team that studied cardiovascular risk in the Old Order Amish. Because of founder effects, some rare variants are much easier to detect in that population than in the general population. Our initial signal sat inside a large linkage block, and referees quite reasonably pushed us hard: β€œyou need to do a better job showing which of the genes in this region is actually responsible.” It took us a couple of years of additional work to satisfy them before the paper was finally accepted in *Science*.

The gene we eventually nailed down was **B4GALT1**, where a rare missense variant appears to reduce cardiovascular risk. Importantly, carriers in the Amish population appear to live normal lives, which suggested that the biological perturbation might be tolerated.

I recently learned that a biotech company is now developing an RNA-editing therapy intended to mimic that protective variant. It’s still early-stage, and most such programs never reach the clinicβ€”but it’s gratifying to see the idea travel that far down the translational pipeline.

Human genetics β†’ biological mechanism β†’ therapeutic hypothesis.
Sometimes the path from discovery to possible therapy takes many years, but moments like this remind me why that work is worth doing.

The work I was part of:

https://pubmed.ncbi.nlm.nih.gov/34855475/

https://patents.google.com/patent/US20180346888A1/en

The Biotech:
https://www.investing.com/news/swot-analysis/proqr-therapeutics-swot-analysis-rna-editing-pioneers-stock-faces-clinical-hurdles-93CH-4192412

https://www.proqr.com/press-releases/proqr-announces-initial-pipeline-targets-and-highlights-axiomerr-rna-editing-platform-technology-at-rd-event

https://www.proqr.com/science/pipeline

A small moment of scientific gratification. Many years ago I was part of a team that studied cardiovascular risk in the Old Order Amish. Because of founder effects, some rare variants are much easier to detect in that population than in the general population. Our initial signal sat inside a large linkage block, and referees quite reasonably pushed us hard: β€œyou need to do a better job showing which of the genes in this region is actually responsible.” It took us a couple of years of additional work to satisfy them before the paper was finally accepted in *Science*. The gene we eventually nailed down was **B4GALT1**, where a rare missense variant appears to reduce cardiovascular risk. Importantly, carriers in the Amish population appear to live normal lives, which suggested that the biological perturbation might be tolerated. I recently learned that a biotech company is now developing an RNA-editing therapy intended to mimic that protective variant. It’s still early-stage, and most such programs never reach the clinicβ€”but it’s gratifying to see the idea travel that far down the translational pipeline. Human genetics β†’ biological mechanism β†’ therapeutic hypothesis. Sometimes the path from discovery to possible therapy takes many years, but moments like this remind me why that work is worth doing. The work I was part of: https://pubmed.ncbi.nlm.nih.gov/34855475/ https://patents.google.com/patent/US20180346888A1/en The Biotech: https://www.investing.com/news/swot-analysis/proqr-therapeutics-swot-analysis-rna-editing-pioneers-stock-faces-clinical-hurdles-93CH-4192412 https://www.proqr.com/press-releases/proqr-announces-initial-pipeline-targets-and-highlights-axiomerr-rna-editing-platform-technology-at-rd-event https://www.proqr.com/science/pipeline

05.03.2026 20:31 πŸ‘ 0 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
Breaking (via WSJ & NBC News): Trump reportedly considering firing DHS Secretary Kristi Noem
Two major outlets β€” The Wall Street Journal and NBC News β€” are reporting that Donald Trump is considering firing Homeland Security Secretary Kristi Noem following contentious congressional hearings earlier this week.
According to Capitol Hill and administration sources cited by both outlets:
β€’ Trump has begun asking aides and Republican lawmakers for possible replacements.
β€’ The trigger appears to be Noem’s performance during hearings this week, where she faced sharp questioning from both parties.
β€’ Trump was reportedly particularly frustrated by her responses about a roughly $220 million DHS advertising campaign encouraging immigrants to self-deport.
β€’ One GOP senator told NBC that the hearings were essentially β€œwater boiling over the edge of the pot.”
β€’ Louisiana Senator John Kennedy reportedly described Trump as β€œpissed” about the testimony.
At the moment no final decision has been made, but multiple sources told both of these outlets that Trump has been calling Republican lawmakers on Capitol Hill this week to discuss his dissatisfaction with Noem’s performance.
As of this writing, WSJ and NBC appear to have the scoop, with other outlets likely working their sources now.

Breaking (via WSJ & NBC News): Trump reportedly considering firing DHS Secretary Kristi Noem Two major outlets β€” The Wall Street Journal and NBC News β€” are reporting that Donald Trump is considering firing Homeland Security Secretary Kristi Noem following contentious congressional hearings earlier this week. According to Capitol Hill and administration sources cited by both outlets: β€’ Trump has begun asking aides and Republican lawmakers for possible replacements. β€’ The trigger appears to be Noem’s performance during hearings this week, where she faced sharp questioning from both parties. β€’ Trump was reportedly particularly frustrated by her responses about a roughly $220 million DHS advertising campaign encouraging immigrants to self-deport. β€’ One GOP senator told NBC that the hearings were essentially β€œwater boiling over the edge of the pot.” β€’ Louisiana Senator John Kennedy reportedly described Trump as β€œpissed” about the testimony. At the moment no final decision has been made, but multiple sources told both of these outlets that Trump has been calling Republican lawmakers on Capitol Hill this week to discuss his dissatisfaction with Noem’s performance. As of this writing, WSJ and NBC appear to have the scoop, with other outlets likely working their sources now.

05.03.2026 18:40 πŸ‘ 1 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
ORCID

orcid.org/0000-0001-64...

europepmc.org/authors/0000...

05.03.2026 13:51 πŸ‘ 0 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
ORCID

Do you publish in peer-reviewed journals? Maintain an ORCID record & include a link to ORCID in your social media profiles. Lets you say these are mine, these by authors with similar names are not mine. Lets others verify your history of publishing research. Mine goes back decades now.

05.03.2026 13:51 πŸ‘ 0 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0

me: starfish

Scientist: not a fish

me: jellyfish

Scientist: not a fish

me: seahorse

Scientist: fish

04.03.2026 03:38 πŸ‘ 1562 πŸ” 176 πŸ’¬ 78 πŸ“Œ 18
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My time-lapse of Tuesday mornings' lunar eclipse shows the subtle changes in the light refracted by Earth's atmosphere. 14 frames over 65 min cover totality. All frames processed identically and assembled into a video with cross dissolve transitions to smooth it. Details in ALT. #astrophotography

05.03.2026 00:40 πŸ‘ 362 πŸ” 57 πŸ’¬ 7 πŸ“Œ 1

The woke liberal cucks at Anthropic cut us off from using Claude right before we were going to ask it to generate a reason why we're invading Iran.

by Pete Hegseth

04.03.2026 15:16 πŸ‘ 727 πŸ” 117 πŸ’¬ 6 πŸ“Œ 3

A year or so ago I asked a faculty members to stand up an on-the-shelf research protocol that could be implemented on short notice to begin evaluating how military contingency operations are impacting the health & well being of military families. Guess it’s time to break the glass.

05.03.2026 04:02 πŸ‘ 9 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0

Americans are tired of the government wasting their money on Medicaid and schools. They want it spent on security details for Stephen Miller, Tom Homan, and Kash Patel's girlfriend.

by J.D. Vance

04.03.2026 18:48 πŸ‘ 754 πŸ” 116 πŸ’¬ 9 πŸ“Œ 3

Well, I'm not a dad but I am an uncle...

05.03.2026 06:20 πŸ‘ 0 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

Perot as Darth Vader, I like.

Elon Musk is of course Hugo Drax from James Bond: in both the novel and film versions he is an evil rocket manufacturer.

05.03.2026 06:18 πŸ‘ 0 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
Three-dimensional cube whose surfaces are textured with flowing blue and copper patterns containing scattered molecular diagrams. The repeating structures resemble medicinal chemistry drawings embedded in a glossy, enamel-like surface, giving the impression of drug molecules suspended within a translucent cube.

Three-dimensional cube whose surfaces are textured with flowing blue and copper patterns containing scattered molecular diagrams. The repeating structures resemble medicinal chemistry drawings embedded in a glossy, enamel-like surface, giving the impression of drug molecules suspended within a translucent cube.

White background containing several black line-drawn chemical structures of drug molecules arranged across the page, including ring systems, amines, esters, and steroid-like frameworks. One structure is shown as a colored 3-D ball-and-stick model, while the others appear as standard medicinal chemistry skeletal diagrams.

White background containing several black line-drawn chemical structures of drug molecules arranged across the page, including ring systems, amines, esters, and steroid-like frameworks. One structure is shown as a colored 3-D ball-and-stick model, while the others appear as standard medicinal chemistry skeletal diagrams.

05.03.2026 03:52 πŸ‘ 0 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0