Considering my book "The Tree of Life" for introductory evolution class? I have a few complimentary copies to evaluate. Please DM me. And please repost.
Review in Science described it as "..a fantastic informal introduction to a course on evolution.. recommended it to my first-year students".
06.03.2026 09:52
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Congrats Alibek, Yasin et al
24.02.2026 06:38
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Something tells me I should go to the membrane contact sites session...
24.02.2026 05:58
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Sun π is rising over the bay of Eilat/Aqaba and the 2nd day of ILANIT 2026 is coming up.
24.02.2026 04:44
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Long in the making, but happy to present the Chlamydomonas chlororibosome!
Cryo-ETπ¬reveals a large new domain on the small subunit, built from multiple extensions in conserved ribosomal proteins.
bioRxiv π: shorturl.at/q44tG
This suggests greater chlororibosome diversity than expected!
1/n π§΅
10.02.2026 08:35
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#transgenerational transmission of a core #microbiome that protects against downy mildew from soil to #phyllosphere
Fantastic and important study by @jellespooren.bsky.social @rlberendsen.bsky.social
@cornepieterse.bsky.social
academic.oup.com/ismej/advanc...
#plantscience
14.02.2026 17:32
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New review from P Genschikβs team in
@jxbotany.bsky.social 𧬠A fresh look at the huge diversity and functions of plant F-box proteins.
π Open questions & new perspectives for π± biology.
βΆοΈhttps://academic.oup.com/jxb/advance-article-abstract/doi/10.1093/jxb/erag074/8475508?redirectedFrom=fulltext
14.02.2026 18:16
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"The most uncomfortable part for me is that I no longer think that scientific research will resolve the crises that we face."
"I keep doing research not because I think it will save us, but because it would be a form of surrender to stop seeking understanding."
14.02.2026 00:18
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Beautiful #preprint on a novel regulator of plant #autophagy from the @cnaumann123.bsky.social lab. How do plants regulate #autophagosome size??? ER-PM contact sites and Can1 seem to be key! www.biorxiv.org/content/10.6...
14.02.2026 10:23
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Our own βDorothy Matikiβ presented her research (on autophagy in π
ripening) impressively and earned her M.Sc. title! ππΎ
Soon Dorothy will meet the @weizmanninstitute.bsky.social Doctoral studies committee to (hopefully) approve her joining the lab of Prof. βMichal Sharonβ.
All the best Dorothy!
14.02.2026 10:14
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#SaturdayVibes
17.01.2026 13:55
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A CK2-FBXW11 kinase-E3 ubiquitin ligase cascade is a metabolic sensor regulating Tryptophan 2,3-dioxygenase stability
Small molecules toggling the ubiquitin-proteasome system (UPS) are powerful regulators of protein degradation. Yet, mechanistic knowledge of how endogenous ligands gate UPS decisions remains rudimentary. Here, we define control of UPS access to Tryptophan-2,3-dioxygenase (TDO2), which converts the essential amino acid tryptophan (Trp) to N-formylkynurenine. When Trp concentrations are limiting, TDO2 is degraded to avert tryptophanemia. Using CRISPRi screening and biochemistry, we identify a CK2-FBXW11 kinase-E3 ligase cascade that generates and recognizes tandem TDO2 phosphodegrons when not protected by Trp. Trp binding to an exosite safeguards TDO2 from phosphorylation-dependent ubiquitylation. Effects of Trp analogs on CK2-FBXW11-dependent ubiquitylation indicated that the indole, amino, and carboxylate groups are necessary for substrate shielding. Cryo-EM reveals how these moieties order a region proximal to the phosphodegrons; without Trp, this segment is flexible, enabling phosphorylation-coupled ubiquitylation. Overall, our data uncovered an endogenous small molecule allosterically stabilizing its own metabolizing enzyme through protection from a phosphorylation-ubiquitylation cascade. ### Competing Interest Statement B.A.S. is a member of the scientific advisory boards of Proxygen and Lyterian. The other authors declare no competing interests. Max Planck Society, https://ror.org/01hhn8329 European Union, ERC AdvG, UPSmeetMet, 101098161 to BAS Boehringer Ingelheim Fonds, https://ror.org/00dkye506
New year, new preprint! π
We are excited to share our recent work on #E3 ligase regulation in #metabolism!
www.biorxiv.org/content/10.6...
#ubiquitin #targetedproteindegradation #chemicalbiology
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13.01.2026 13:49
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a black background with the word idiocracy written in white letters .
ALT: a black background with the word idiocracy written in white letters .
Dear @dfg.de So, I will spend months writing a grant and you will let people judge it with AI tools that are trained on predatory journals like Frontiers, MDPI or alike that are practically not peer-reviewed??? Is this how you will select cutting edge science??? #idiocracy
08.01.2026 15:30
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Fig. 1 (shortened, full legend in paper): Complexity of gynoecium development shown with confocal microscopy imaging. (A) Meristematic stages of floral development in which the inflorescence meristem (IM) is observed; from stage 3, the sepal primordia (asterisks) are observed; in stage 4, the developing sepals (asterisks) partially cover the floral meristem (FM); and in stage 5, the FM is completely covered by the sepals. (B) Stage 6 in which the gynoecium is established with the appearance of the primordium of the gynoecium. (C) In stage 7, the middle and lateral domains can be differentiated (marked by dotted lines). (DβH) Longitudinal view of the gynoecium from stage 8 to 12. At stages 8 and 9, the gynoecium grows as a hollow tube and the valves and young replum can be seen. (F and G) Longitudinal view of stage 10 and 11 gynoecia showing the replum and valves. (H) Mature stage 12 gynoecium showing the stigma, style, and ovary, the latter formed by the valves and replum.
πΈ Flowering Newsletter Review πΈ
LΓ³pez-GΓ³mez et al. review the role of proteinβprotein interactions in flower and fruit development and discuss the latest techniques to study them.
π doi.org/10.1093/jxb/...
#PlantScience π§ͺ @defolter-lab.bsky.social
09.12.2025 13:23
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Our work now on @jxbotany.bsky.social. Make sure you add some Cas13a fluorescent virus detection to your Christmas lights β¨οΈ
24.12.2025 17:58
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Researchers developed a #CRISPR-based method that's user-friendly, extraction-free, 15 min protocol for on-site #virus #detection using a portable fluorescence viewer and a mobile #phone camera directly from RNA of several crop species, including #tomato, #cucumber, and #rapeseed. π bit.ly/4p6Jo8t
24.12.2025 17:47
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A 1.25 A!!! cryo EM structure of rubisco.
24.12.2025 11:15
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Christmas π and Hanukkah π celebration in Hala's (Dr. Khamesa-Israelov) place with all group members. What a treat π₯π»π°
18.12.2025 13:41
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Christmas π and Hanukkah π celebration in Hala's (Dr. Khamesa-Israelov) place with all group members. What a treat π₯π»π°
18.12.2025 13:41
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Organelles do NOT have a single uniform pH.
And if you think they must, because βprotons diffuse fast,β this paper is for you.
A thread on why that assumption is wrong; and what we found instead. π§΅ 1/n
17.12.2025 00:46
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The Clavel Group is recruiting a new postdoc for two possible projects dealing with plant-virus interactions and selective autophagy! More (wordy) details below β¬οΈπ±π¦
16.12.2025 17:15
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