The Lancet Diabetes & Endocrinology

Automated insulin delivery systems and improved glycaemic outcomes in type 1 diabetes: what comes next? Early clinical trials established the safety and feasibility of closed-loop insulin delivery, but the 2019 iDCL trial1 marked the first large, outpatient, randomised, controlled trial to show a greate...

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Automated insulin delivery systems and improved glycaemic outcomes in type 1 #diabetes: what comes next? www.thelancet.com/journals/lan... #T1D #CGM #AID

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Compared with multiple daily injections with #CGM, #AID resulted in improved glycaemia among people with type 1 #diabetes with suboptimal glycaemic outcomes at baseline www.thelancet.com/journals/lan... #T1D

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Diabetes and mental health This Review summarises the research into five common mental health problems that can affect adults living with type 1 diabetes, type 2 diabetes, or gestational diabetes: fear of hypoglycaemia, diabete...

People with #diabetes want to talk with their diabetes health professionals about the emotional side of living with and managing diabetes www.thelancet.com/journals/lan...
#T1D #T2D #GDM #MentalHealth

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Beyond the heart: the urgent need for a dementia-forward diabetes agenda The clinical practice of diabetes management has undergone a paradigm shift over the past two decades. GLP-1 receptor agonists and SGLT2 inhibitors have expanded the therapeutic focus beyond glycaemic...

Hui Shao & colleagues comment on:
Beyond the heart: the urgent need for a #dementia-forward #diabetes agenda thelancet.com/journals/lan...
#T2D #CVD #dementia #cancer

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Trends in cause-specific mortality among people with and without diabetes in high-income settings: a multinational, population-based study Mortality from cardiovascular disease and diabetes has declined among people with diabetes in most jurisdictions, whereas mortality from dementia has increased markedly, independent of age. Cardiovasc...

New—Trends in cause-specific #mortality among people with and without #diabetes in high-income settings: a multinational, population-based study thelancet.com/journals/lan...
#T2D #CVD #dementia #cancer

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Cover of the Lancet Obstetrics, Gynaecology, & Women’s Health March, 2026, issue.

It’s been 1 year since we launched The Lancet Obstetrics, Gynaecology, & Women’s Health.

This #InternationalWomensDay, explore the journal dedicated to bridging clinical evidence and practice to help transform women’s lives.

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Additional benefits of combining GLP-1 receptor agonist use with lifestyle modification GLP-1 receptor agonists have largely contributed to revolutionising pharmacological therapy of type 2 diabetes. They are among the most potent glucose-lowering agents, while also eliciting bodyweight ...

Stefano Del Prato & Anna Solini comment on:
Additional benefits of combining #GLP-1 receptor agonist use with #lifestyle modification thelancet.com/journals/lan... #T2D #CVD

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#Combined associations of #GLP-1 receptor agonists and a #healthy #lifestyle with #cardiovascular outcomes among individuals with type 2 #diabetes: a prospective cohort study thelancet.com/journals/lan... #T2D #CVD

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Reuniting diabetes through the islet coordinate framework For nearly a century, type 2 diabetes has been understood and managed as a single clinical entity. However, converging discoveries now point to type 2 diabetes as a constellation of subtypes defined b...

For nearly a century, type 2 #diabetes has been understood and managed as a single clinical entity. However, converging discoveries now point to type 2 diabetes as a constellation of subtypes defined by genetic, metabolic, and phenotypic diversity www.thelancet.com/journals/lan... #T2D

Risk of recurrence after successful surgery for Cushing's disease and association with USP8 genotype and tumour size: an international, retrospective, longitudinal cohort study Combined USP8 genotype–tumour size identified patients at increased risk of recurrence, particularly in largely heterogeneous groups of patients with non-invasive tumours or low postoperative serum co...

Combined #USP8 #genotype–tumour size identified patients at increased risk of #recurrence, particularly in largely heterogeneous groups of patients with non-invasive tumours or low postoperative serum cortisol not considered high risk in standard care www.thelancet.com/journals/lan...
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Application of continuous glucose monitoring and automated insulin delivery technologies for #pregnant #women with type 1, type 2, or gestational #diabetes: an international consensus statement thelancet.com/journals/lan...
#T1D #T2D #GDM #CGM #AID
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Menopausal hormone treatment and breast cancer Breast cancer risk is a central concern in shared decision-making when considering menopausal hormone treatment (MHT). Women spend approximately 40% of their lives in menopause, and climacteric sympto...

Breast cancer risk in women considering menopausal hormone treatment (MHT) remains complex. The main sources of high-quality data come from large RCTs, which show reduced risk from oestrogen-only MHT & an increased risk from combined MHT (oestrogen + progestogen) www.thelancet.com/journals/lan....

Figure: 'Inclusive FemTech: what makes it work'. Copyright: Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.

Despite comprising half the global population, women's health remaining a significant blind spot in modern medicine.

A new Viewpoint outlines FemTech, technology-enabled solutions to address the barriers & inequalities in care: spkl.io/63329AatGL

#IWD2026 #InternationalWomensDay

Adrenal tumours are commonly encountered in every endocrinology practice and related subspecialties nowadays, and require the most accurate evidence-based management, treatment, and follow-up thelancet.com/journals/lan...
#adrenal #tumour
#phaeochromocytomas #paragangliomas #PPGLs

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Prolactinomas are the most prevalent functional pituitary adenomas and can result in a proliferative endocrine disorder that is typically highly responsive to medical therapy www.thelancet.com/journals/lan...
#prolactinomas
#hyperprolactinaemia
#pituitary #adenomas

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Recent advances in research and care of familial hypercholesterolaemia Heterozygous familial hypercholesterolaemia is a common, autosomal semi-dominant condition characterised by elevation of LDL cholesterol from birth and early onset of atherosclerotic cardiovascular di...

Despite advances, #familial #hypercholesterolaemia is still inadequately diagnosed and undertreated, with many affected people remaining at high risk of early #cardiovascular disease www.thelancet.com/journals/lan...
#HeFH #HoFH #ASCVD

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Combined associations of GLP-1 receptor agonists and a healthy lifestyle with cardiovascular outcomes among individuals with type 2 diabetes: a prospective cohort study Adherence to low-risk lifestyle habits combined with GLP-1 receptor agonist use was associated with a greater reduction in MACE risk than either approach alone, underscoring the importance of integrat...

To our knowledge, this is the first study to show that optimising #nutrition and #lifestyle can further mitigate #cardiovascular risk in conjunction with #pharmacotherapy in type 2 #diabetes thelancet.com/journals/lan...
#T2D #CVD #GLP-1 receptor agonists

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Trajectory of weight regain after cessation of GLP-1 receptor agonists: a systematic review and nonlinear meta-regression GLP-1RA cessation is associated with a predictable and decelerating pattern of weight regain, which appears to plateau below pre-treatment levels, suggesting that partial weight-loss benefit may persi...

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Trajectory of #weight #regain after cessation of #GLP-1 receptor agonists: a systematic review and nonlinear meta-regression www.thelancet.com/journals/ecl...
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Figure 4: Conservative management for all patients with ADPKD

Autosomal dominant polycystic kidney disease (ADPKD) is the most common genetic cause of chronic kidney disease.

A new Review focuses on current approaches to diagnosis, treatment, and specific aspects of clinical management. Read more: spkl.io/63329AxPWv

Glucocorticoid-induced osteoporosis: novel concepts and clinical implications Despite advances in targeted therapies, treatment with glucocorticoids remains a mainstay in the management of various immune-mediated diseases. High cumulative doses of exogenous glucocorticoids lead...

Fragility fractures remain a common and serious complication of long-term oral #glucocorticoid therapy that might affect all skeletal sites, although the spine is particularly prone to #fractures owing to its high proportion of trabecular bone www.thelancet.com/journals/lan...
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Risk of recurrence after successful surgery for Cushing's disease and association with USP8 genotype and tumour size: an international, retrospective, longitudinal cohort study Combined USP8 genotype–tumour size identified patients at increased risk of recurrence, particularly in largely heterogeneous groups of patients with non-invasive tumours or low postoperative serum co...

Our results support a novel three-tier risk assessment system that integrates #USP8 #genetic status and tumour size to predict #recurrence after first #pituitary #surgery www.thelancet.com/journals/lan...
#Cushing's disease
#OpenAccess

#MedSky #EndoSky #OncSky

Due to its vague presentation, diagnosis of #Addison's disease is often delayed, and in some cases, individuals present in adrenal crisis www.thelancet.com/journals/lan...
#adrenal #insufficiency

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From survival to freedom: redefining success in type 1 diabetes Type 1 diabetes has shifted from a condition once associated with early mortality to a chronic disease owing to the development of intensive insulin therapy, continuous glucose monitoring, and hybrid ...

One century ago, insulin transformed type 1 #diabetes from a fatal condition into a survivable one. The next century should aim to transform it into a condition compatible with an unencumbered life www.thelancet.com/journals/lan... #T1D

USP8 genotype and tumour size as predictors for recurrence in Cushing's disease The study by Qilin Zhang and colleagues published in The Lancet Diabetes & Endocrinology evaluates the risk of recurrence following successful surgery for Cushing's disease and examines its associatio...

Maya Beth Lodish comments on:
#USP8 #genotype and tumour size as predictors for #recurrence in #Cushing's disease thelancet.com/journals/lan...
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New—Risk of #recurrence after successful #surgery for #Cushing's disease and association with #USP8 #genotype and tumour size: an international, retrospective, longitudinal cohort study thelancet.com/journals/lan...
#OpenAccess

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In the past three decades, there has been growing recognition of the complex interplay between mental health and physical health among people with #diabetes www.thelancet.com/journals/lan...
#T1D #T2D #GDM #MentalHealth

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Research in context panel for Lancet paper "Adult obesity and risk of severe infections: a multicohort study with global burden estimates". Copyright: 2025 The Author(s). Published by Elsevier Ltd. CC BY 4.0.

People with obesity at 70% higher risk of serious infection with one in ten infectious disease deaths globally potentially linked to obesity, study suggests.

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Temporal changes and genetic susceptibility to type 2 diabetes (1984–2019; HUNT): a longitudinal, population-based study Our findings suggest an increasing gap in diabetes prevalence between the most and least genetically susceptible. This suggests that people with a high genetic susceptibility to type 2 diabetes could ...

As the environment has become more diabetogenic over time, our findings suggest that for many people with type 2 #diabetes, the development of the disease, or their age at which it develops, may depend on the interaction between environmental & #genetic factors www.thelancet.com/journals/lan... #T2D

3 months of romosozumab: a pragmatic clinical solution A longstanding goal in the treatment of osteoporosis has been rejuvenating the ageing skeleton to essentially reverse or cure osteoporosis. Although antiresorptive drugs such as bisphosphonates or den...

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3 months of romosozumab: a pragmatic clinical solution www.thelancet.com/journals/lan...
#postmenopausal #osteoporosis #WomensHealth
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3 months vs 12 months of romosozumab for postmenopausal osteoporosis (LIDA): an open-label, non-inferiority, randomised controlled trial In postmenopausal women at high risk of fracture, 3 months of romosozumab followed by 9 months of denosumab was non-inferior to 12 months of romosozumab in increasing total hip BMD. Given the expense,...

The results of this randomised controlled trial provide rationale for a shorter, 3-month course of romosozumab compared with the standard 12-month regimen, thereby reducing cost and injection burden while potentially limiting cardiovascular risk www.thelancet.com/journals/lan...
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