Vaults. They are cell biology's greatest puzzle! This preprint from Martin Beck's lab shows them docked on ER membranes with a ribosome inside. What on earth is going on there??
#CellBiology #WTFology
www.biorxiv.org/content/10.6...
Our new preprint reveals that 🪰's Cnn and 🪱's SPD-5 both form condensates in vitro, but assemble via divergent mechanisms in vivo. We show how phosphorylation unlocks Cnn’s autoinhibited scaffold and identify conserved features in 🚶♂️'s CDK5RAP2.
🚨 We are hiring a #postdoc in Quantitative Cell Biology/Biochemistry. Join us if you are interested in using super-resolution STED & cryoET to uncover self-organization dynamics of epithelial cell interfaces & glycobiology collaboration with WuLab
Deadline 31 August
www.nature.com/naturecareer...
Spent a memorable summer at Physiology course at @mblscience.bsky.social Very coooool science with some lovely people! Thanks @brangwynnelab.bsky.social and @gladfelterlab.bsky.social for being amazinnnng course coordinators! 🧵
Exciting news! Our latest paper reveals that Spd-2 (CEP192) recruits Polo & Aurora A to build two scaffolds—Polo-dependent Cnn (for strength) & Aurora A–dependent TACC (for protein concentration)—crucial for centrosome assembly in Drosophila. #CellBiology #Centrosome www.science.org/doi/10.1126/...
