Kaiser Lab

Two group leader positions available in the broader areas of RNA science, RNA technologies, and RNA medicine. Attractive packages and a great environment. Come and join us at Helmholtz RNA Würzburg, Bavaria.

Spatiotemporal NAIL-MS analysis shows that ALKBH5 does not affect global m6A turnover in human mRNA across subcellular compartments under standard growth conditions bit.ly/4lvVtC6

We’re moving in! Posters are going up, coffee is being ordered, and the countdown is real.
Final prep before minds meet in Frankfurt. 2 days until we start
#ConferenceVibes #RNAmods #HRP2025

The conference print materials have arrived — and so has the excitement!
🧭 Our goal? To build the foundation for reproducible RNA mass spectrometry, where labs worldwide can trust and compare results.
#HRP2025 #RNAstandards #SciModom

In only 4 days, we’re combining theory and practice: the training module of HRP 2025 covers protocols, tools, and expert insights — from digestion to data analysis.
Perfect for anyone entering the field or refreshing their skills.
Hashtag#RNAtraining Hashtag#MassSpec Hashtag#HRP2025

Three instruments, one goal: the Kaiser Lab Agilent setup is now ready to contribute to our harmonization mission.
Side by side with Thermo and Bruker, this is harmonization in action.
#Agilent #HRP2025 #LCMS 5 days left!

6 days to go!
Precision incoming: The Bruker instrument is now in set-up and ready for action! Thanks for everyone who made this possible!
Can three platforms agree on what modified RNA looks like? Follow us and find out.
#Bruker #LCMSMS #RNAmodification #HRP2025
(picture by Dirk Wunderlich)

Behind every workshop, there’s serious logistics: last week we welcomed the Thermo system that will power part of our experimental module.
Big thanks to everyone who made this happen!
#MassSpec #ThermoFisher #RNAanalytics #HRP2025

8 days to go!

Our experimental module is the heart of the workshop:
3 platforms, 1 benchmark dataset, and a clear mission — harmonize how we measure modified RNA.
Get ready to generate data that shapes the future.
#Benchmarking #HRP2025 #RNAmods

only 9 days left until the HRP Workshop 2025!
Here’s a first look at our talks and breakout sessions: the program reflects the full diversity of the RNA modification field.
Designed for discussion, connection, and community progress.
#HRP2025 #OpenScience #Epitranscriptome #RNA

https://www.preprints.org/manuscript/202507.2155/v1 "Synthetic mRNA Vaccines and Transcriptomic Dysregulation: Evidence from New-Onset Adverse Events and Cancers Post-Vaccination"

This new preprint was designed so poorly that it provides absolutely no proof that mRNA vaccines caused cancer/other diseases.
It compared 10 (!) handpicked sick patients to 803 healthy patients. And behold, they show different RNA expression profiles. Because they were sick.
Link in alt.

1st Workshop of the Human RNome Project - Scientific Revolution Begins in Frankfurt! #HRP2025 @goetheuni.bsky.social
10 days to go!

Unfortunately this was not done with my lab. I think it was done with Tobias Kaiser's Lab?

NAIL-MS Elucidates Crucial tRNA U34 Modifications in Response to Heat Stress across Eukaryotes and Prokaryotes Global warming leads to rising temperatures, necessitating organismal adaptation at the cellular level. One potential mechanism for maintaining proteo…

Another great RNA modification-mass spec paper from @kaiserlab.bsky.social which we were very happy to contribute! @biouea.bsky.social @norwichrnaclub.bsky.social www.sciencedirect.com/science/arti...

The Kaiser Lab is happy to host this workshop at @goetheuni.bsky.social in wonderful Frankfurt, Germany. Here is a sneak preview on the draft program.

Human RNome Project Our mission is to advance RNA science to impact human health, food security and boost biomanufacturing.

Join us in Frankfurt, Aug 4–9, for the 2025 Human RNome Project Workshop!
Focus: RNA modifications, mass spec, direct RNA seq & more. Help shape the roadmap to decode the human RNome.
🔗 humanrnomeproject.org/2025-workshop-in-germany
#RNA #HumanRNomeProject

🎉 We’re absolutely thrilled: SCALE has been selected as a DFG Excellence Cluster!
A huge thank you to our incredible team—this would not have been possible without your dedication and talent. 🙌 @dfg.de
#ClustersOfExcellence #SCALEcluster 🧵

Deutschlandkarte der Verteilung der Exzellenzcluster auf Bundesländer und Universitäten.

Die #Exzellenzcluster stehen fest: Heute hat die Exzellenzkommission 70 Projekte zur Förderung ausgewählt. 45 Cluster werden fortgesetzt, 25 neu eingerichtet. Die Förderung beginnt ab 1. Jan. 2026 für 7 Jahre, die Fördersumme beträgt insg. 539 Mio. €/Jahr. Die Liste: www.dfg.de/resource/blo... 1/3

What better way to start things off than with a throwback to our ALL-tRNAseq paper?! genesdev.cshlp.org/content/37/5...

Protonated Glutamate and Aspartate Side Chains Can Recognize Phosphodiester Groups via Strong and Short Hydrogen Bonds in Biomacromolecular Complexes Phosphodiester groups occur ubiquitously in nature, e.g. in nucleic acids or in cyclic (di-)nucleotides important for signal transduction. Proteins often use polar or positively charged amino acids t...

You thought Glu/Asp don't like RNA or DNA? Maybe you even introduced them into your protein to stop such interactions?
😱🧪
Think again! New paper @angewandtechemie.bsky.social with Wöhnert lab shows structural context matters for phosphodiester interactions!
onlinelibrary.wiley.com/doi/10.1002/...

Thank you #MIT

Postdoc position mass spectrometry/ chemical proteomics in Geneva, Switzerland 🇨🇭 with my colleague Sascha. Deadline is coming soon ⤵️

Are you a postdoc ready for transition to an independent position? You connect infection biology with cutting-edge structural biology or multimodal imaging? Are you aware of such a colleague?

I am seeking speakers for "The Next Generation in Infection Biology" microsymposium on June 6 2025.

Come join our team! We have an opening for a research associate ("Ratsstelle"). Expertise in nucleotide chemistry and LC-MS is required. 👉 job-portal.lmu.de/jobposting/b... Deadline for application is June 01, 2025.

Thank you for selecting our project! We are excited for the upcoming results.

Direct RNA sequencing of the Escherichia coli epitranscriptome uncovers alterations under heat stress Abstract. Modifications of RNA, known as the epitranscriptome, affect gene expression, translation, and splicing in eukaryotes, with implications for devel

Heat stress impacts RNA modification levels in E. coi !🦠 #microsky #rnasky academic.oup.com/nar/article/...

RNA Salon in mRNA Translation

We have an exciting lineup with Keynote by: Marvin Tanenbaum (Hubrecht/ Delft)

Please RT
@goetheuni.bsky.social @cpi-exstra.bsky.social

We are happy to announce that we will host the 1st workshop of the human RNome project consortium in Frankfurt am Main this August. More information can be found at kaiser-lab.de

Chemical nucleases are a robust alternative for RNase H cleavage of human ribosomal RNA Besides the abundant ribosomal and transfer RNA transcripts (rRNA and tRNA, respectively), there are tens of thousands of long coding (mRNA) and non-coding transcripts (lncRNA) within each cell whose ...

The third is from Hagen, who studied artificial nucleases and their potential for rRNA removal. you can read up his work in PlosOne. Well done Hagen!
journals.plos.org/plosone/arti...