Dutzler lab

Laser flash melting cryo-EM samples to overcome preferred orientation - Nature Methods Individual proteins tend to adopt preferred orientations when subjected to vitrification for cryo-electron microscopy analysis. A laser flash melting procedure followed by rapid revitrification provid...

A laser flash melting procedure, followed by rapid revitrification, provides a simple approach to help mitigate the preferred orientation problem that plagues cryo-EM analysis.

www.nature.com/articles/s41...

Congratulations! 🎉

Structural basis for lipid transport at membrane contact sites by the IST2–OSH6 complex - Nature Structural & Molecular Biology IST2 serves as a tether between the endoplasmic reticulum and the plasma membrane in yeast. Here, Arndt et al. interrogate its interaction with OSH6, revealing that the two proteins remain associated ...

The second part of my PhD work is now out in NSMB! 🚨✨
We explored how IST2, a known ER–plasma membrane tether in S. cerevisiae, facilitates lipid transfer at membrane contact sites.
Check it out: www.nature.com/articles/s41...

Check out the recent Alzforum article about our lab’s paper on TTYH2 and ApoE! www.alzforum.org/news/researc...

Interactions between TTYH2 and APOE facilitate endosomal lipid transfer - Nature The Tweety homologue TTYH2 is identified as the lipid transfer mediator for APOE-containing lipoproteins.

🚨 Anastasiia’s latest paper is out! We discovered that TTYH2 and ApoE bind in the endosomal lumen, where TTYH2 then facilitates lipid transfer from ApoE into the endosomal membrane. Check it out now in Nature: www.nature.com/articles/s41...