Topher Hübel

🧵 New publication from the PGC Anxiety Working Group. Our GWAS meta-analysis of anxiety disorders is now published in @natgenet.nature.com! 🔗: doi.org/10.1038/s415...

My photo shows the so-called ‘Trier Gold Treasure’ in a museum display case. It is a Roman coin hoard made up of some 2,650 gold aurei. The small round gold coins are spread randomly in a dense pile across a light-coloured display case surface. To the upper right of the coin mound is the broken bowl-shaped bottom of the original copper alloy vessel that held the hoard. The metal is coloured green with corrosion. Several gold coins are scattered inside the bowl. In the lower left corner of the display case is another large, irregular fragment of the original container. Museum information label: In 1993, a bronze vessel with 2650 Roman gold coins (aurei) is discovered in Trier. It is the largest Roman gold coin treasure ever found. The Aureus was in the 1st and 2nd Century the standard coin of the Roman gold minting with an average weight of 7.27 g, with a very high fineness of approx. 980/1000. The coins depict 29 different emperors, empresses or relatives of the imperial house. The oldest coins were minted between 63 and 64 AD, the youngest between 193 and 196 AD. The coins were inside the vessel, which was accidentally discovered by an excavator, rolled up in leather bags. The bags were decorated with leather straps and closed enamel seal capsules. The treasure revealed numerous secrets in its scientific processing: it probably did not represent private assets, but a state treasury that was carefully managed and over a longer period of time and enlarged. During a civil war, the gold coins were finally buried in a cellar in 196 AD and then fell into oblivion. Presumably the former administrator of the treasury took his knowledge of the hiding place with him to the grave.

The Trier Gold Hoard!

The largest #Roman gold coin hoard ever found!

More than 2,650 Roman aurei, weighing 18.5 kg, were discovered inside a bronze vessel wrapped in leather bags, during construction work in 1993. The coins date from 63 AD to 196 AD.

Rheinisches Landesmuseum Trier 📷 by me

The Sexologist Who Unlocked the Female Orgasm Fifty years ago, a controversial writer named Shere Hite taught us how to talk about sex and pleasure, selling books by the millions. Why do so few people know her name today?

50 years ago, sexologist Shere Hite conducted a groundbreaking study finding that most women do not reach orgasm by means of vaginal penetration alone. https://www.newyorker.com/magazine/2026/03/09/shere-hite-and-the-hite-report-rosa-campbell-book-review

buchseite aus altem buch. Man müßte wenigstens täglich ein gutes Gedicht lesen, ein schönes Gemälde sehen, ein sanftes Lied hören - oder ein herzliches Wort mit einem Freunde reden, um auch den schöneren, ich möchte sagen, den menschlicheren Teil unseres Wesens zu bilden. KLEIST

hits different wenn man me/cfs hat

Rembrandt's Vision of Zacharias in the Temple rediscovered after 65 years The painting, created by the Dutch master in 1633, had disappeared after being sold in 1961.

Small things to hang onto: they’ve rediscovered a painting by Rembrandt which depicts the Biblical scene when priest Zacharias is told by the Archangel Gabriel that he and his wife will have a son, John the Baptist
www.bbc.co.uk/news/article...

3D drawing of a quincunx. It shows piles of little balls separated by vertical dividers and the shape of the distribution approximates a Gausian

Portrait of Francis Galton by Charles Wellington Furse

#TodayinHistory #dataviz #Onthisday #OTD 📊
📅Feb 27, 1874 Francis Galton demonstrated the quincunx at a meeting of the Royal Institution-- showing how normal distributions arise as sum of small random effects [Stigler:1986, p.276] --
Great example of data physicalization

UN projections suggest that global deaths will exceed global births by 2084. This means: that's when the UN expects global population to decline (most other demographic institutes of course put this date a decade or two earlier). Source: buff.ly/PoGvNwq

Interpreting Confidence Intervals Interactive visualization of confidence intervals

#stats Here's a nifty interactive demo of confidence intervals by
Kristoffer Magnusson

rpsychologist.com/d3/ci/

In an upcoming module of the Statistics Globe Hub, I will show how to create informative visualizations with ggstatsplot in R, how to include statistical results automatically, and how to use this workflow in real projects.

More info: statisticsglobe.com/hub

#Statistics #DataScience #RStats

Happy to share our latest paper, the work of @clarajiang.bsky.social who trained brain-based predictors of depression on the UK Biobank (N=7,500 curated cases and matched controls) using AI/deeplearning as well as efficient statistical learning (BLUP).

See thread below for a summary of findings

Genetic regulation across germline and somatic variation on the Y chromosome contributes to type 2 diabetes - Nature Medicine A genetic study in over 300,000 males reveals that Y chromosome loss affects type 2 diabetes risk differently in East Asians and Europeans. Multi-omics data suggest that this may be due to impaired gl...

Here cell type- and disease-specific metabolic consequences of loss of the Y chromosome #diabetes www.nature.com/articles/s41...

Are obesity drugs causing a severe complication? What the science says Nature - The United Kingdom and Brazil have issued warnings about a possible link between GLP-1 weight-loss drugs and pancreatic inflammation, but the connection is murky.

Are obesity drugs causing a severe complication? What the science says

The United Kingdom and Brazil have issued warnings about a possible link between GLP-1 weight-loss drugs and pancreatic inflammation, but the connection is murky.

www.nature.com/artic...
1/4

Postpartum depression in dads is common – we can now spot and treat it Fathers may get postpartum depression at a similar rate to mothers, but it’s often overlooked. At last, the way we diagnose and treat it is improving, for the good of the whole family

Fathers may get postpartum depression at a similar rate to mothers, but it’s often overlooked. At last, the way we diagnose and treat it is improving, for the good of the whole family

OpenSAFELY news: you can apply to do non-COVID research, from today! | Bennett Institute for Applied Data Science We are delighted to announce that - from today - you can submit applications to the OpenSAFELY service for non-COVID-19 studies.

OpenSAFELY is open from today! Huge thanks to all who supported this vast collaboration: whole population GP data; in a productive platform; innovative privacy protections; unprecedented support from professions, privacy campaigners; &c

Now it's over to users!

www.bennett.ox.ac.uk/blog/2026/02...

198 effect sizes in ego depletion resesrch showed an effect size of d=0.62. Preregistered large replications (including some by original authors) yielded an effect size of 0. No one has been able to offer any other explanation for this huge research waste than massive p-hacking.

The Statistics Globe Hub starts in just one week, on March 2, and new modules will be released every week. Here are the topics of the first ten weeks.

Interested in joining? You can find more information here: statisticsglobe.com/hub

#statistics #datascience #ai #rstats #python

„Sollte das Kind später einmal zu den Mächtigen gehören, dann ist es für uns alle ein Glück, wenn seine Grundhaltung durch Liebe geprägt worden ist und nicht durch Gewalt. Wir müssen von Grund auf beginnen – bei den Kindern. Vielleicht wäre es gut, wenn wir uns alle mahnten: Niemals Gewalt!“ Astrid Lindgren, „Niemals Gewalt!“ (Rede, 1978, Friedenspreis des Deutschen Buchhandels)

Humans are social animals. Our relationships give life meaning and joy. I think we need to bring back parties, dating, and visiting friends.

💔 Suicide risk after involuntary psychiatric care remains elevated for years, not just weeks.

Swedish study: risk nearly 200x higher in first month post-discharge, still 50x elevated at five years.

Personality disorder patients faced greatest vulnerability.

buff.ly/ruJXTOE

#SuicidePrevention

library(tidyplots) x <- c(2.3, 4.5, 6.3, 3.4, 7.8, 6.7) df <- data.frame( x = c(x, x + c(0.8, 0.75)), group = paste0("g", rep(c(1, 2), each = 6)), batch = paste0("b", c(1:6, 1:6)), shuffle = paste0("c", c(1:6, 6:1)) ) df |> tidyplot(group, x, color = group) |> add_boxplot() |> add_data_points() |> add_test_pvalue(paired_by = batch) |> add_line(group = batch, color = "black")

This is how you can do paired testing in #tidyplots 🍒

#rstats #dataviz #phd

How Many People Have Fantasized About Forcing Sex On Others? - Sex and Psychology In my last post, I wrote about people who fantasize about having sex ‘forced’ on them. Today, we’re going to talk about the flip side of these fantasies: people who fantasize about ‘forcing’ sex on others. How many people have had these fantasies before? And where to they come from?

We know it's common for people to fantasize about being "forced" to have sex. But how common it for them to fantasize about forcing sex on someone else? https://www.sexandpsychology.com/blog/2020/3/11/how-many-people-have-fantasized-about-forcing-sex-on-others/

DNA or parents’ reading: what predicts #dyslexia risk?

🧬 Polygenic score → 6%
🎓 Each parent’s education → 6%
📚 Parents' reading ability → 21%

PGS are informative, not diagnostic. Family phenotypes predict at least as much as DNA

Preprint: osf.io/preprints/ps...
21%: doi.org/10.1080/1088...

Nothing grinds my gears like finding a scale development paper and realizing that the items are NOT PUBLISHED IN THE PAPER.

GPR75 in glutamatergic neurons regulates body weight Wyler, S.C. et al. identify a critical neuronal population that is required for GPR75 to exert its obesogenic effects using targeted deletion and reactivation of Gpr75 in glutamatergic neurons.

Studies in mice demonstrate the importance of glutamatergic neurons in GPR75’s regulation of food intake and protection from #obesity www.cell.com/cell-reports...

The decline of child stunting in 122 countries: a systematic review of child growth studies since the 19th century Introduction Child stunting, a measure of malnutrition, is a major global health challenge affecting 148.1 million children in 2022. Global stunting rates have declined from 47.2% in 1985 to 22.3% in ...

Eradicating child stunting was a central feature of the modern health transition. A new paper reviews 923 child growth studies in 122 countries 1814-2016 to show massive decline in child stunting in the 20th century even in hi income countries & surprising heterogeneity in the regional trajectories.

‘The normal should be darkness’: why one Belgian national park is turning off ‘pointless’ streetlights The radical project is an attempt to preserve wildlife in one of Europe’s most light-polluted countries, but can they persuade local people they will still feel safe?

‘The normal should be darkness’

"An increasing amount of research has shown that illuminating night skies is bad for a wide range of species, including insects, birds and amphibians–disrupting their feeding, reproduction and navigation"

It's bad for humans, too.
www.theguardian.com/environment/...

⭐ NEW PAPER ⭐ on a Bayesian approach to sample size calculations for external validation of risk prediction models - account for uncertainty in the assumed true performance of the model - plus calculate assurance probabilities & the value of information
onlinelibrary.wiley.com/doi/10.1002/...

Wow this is a breakthrough in validation of predictive models that fully accounts for point estimates used in predictions being only point estimates. Great work @richarddriley.bsky.social and colleagues! #Statistics #StatsSky

Review: The science of psychedelic medicine www.nature.com/articles/s41... 🍄🐸 read free: rdcu.be/e4g3g

People form beliefs not only as individual agents, but as members of social groups.

Children (4-6 years old) who belonged to a group were more convinced by evidence that supported their ingroup’s belief (and were less convinced by evidence that opposed their ingroup): www.nature.com/articles/s41...