Huge cheers to @kas-umi.bsky.social for successfully defending her PhD thesis!🎉 We are all so happy to celebrate her achievement, and wish her all the best for her future endeavours👏🙌

Graduate No.4 for the lab😉

#proudmoment

Always lovely to be in Vienna - wonderful visit yesterday at ISTA. Grateful to everybody who met me and shared their work - it is really a privilege to have a day of amazing science hearing what people are passionate about and learn new things. Thank you so much @kichevalab.bsky.social for having me

Our postdoc Rohit Harish just presented his work on the regulation of spinal cord size during mouse development at our internal Neuro Data Talk seminar 👏 Great work, Rohit! We are all looking forward to seeing where your research leads us! 👀🔬🐀
#neurodevelopment #development #spinalcord #neuraltube

We are ready for Open Campus at ISTA today 😊
@istaresearch.bsky.social

Rapid transcriptional response to a dynamic morphogen by time integration During development, cells must interpret extracellular signals with speed and accuracy. While morphogen gradients pattern tissues, how cells respond to dynamic morphogens remains unclear. Here, we inv...

New work on dynamics of morphogen signaling:

Cells decode BMP gradient via temporal integration of signaling level, not instantaneous thresholds. While GRN gates response to provide additional spatial input

Morphogen signalling dynamics + GRN for tissue patterning

www.biorxiv.org/content/10.1...

Self-organized pattern formation in the developing mouse neural tube by a temporal relay of BMP signaling Lehr and Brückner et al. develop an in vitro differentiation system that produces self-organized patterns of cell types similar to the ones observed in the dorsal neural tube. They find that to form t...

Good to see this from @kichevalab.bsky.social in final journal format

BMP signalling drives neural tube patterning through a temporal relay mechanism

Lmx1a connects fast negative feedback and slow positive regulation

www.cell.com/developmenta...

Banner for the SY-Stem meeting in Vienna, Austria, March 12-14, 2025

#SYStem2025 :: Vienna, March 12-14 :: #StemCell niches | Deterministic v. stochastic decisions | Germline | Stem cell model systems | #Epigenetics & imprinting | Cell biology of Stem Cells | Transitioning Stem Cells into the clinic; For oral presentations, register by Jan 15! www.sy-stem.org