Manvendra Singh

Happy Holi everyone 🌈
A festival where poetry meets science as every color carries meaning, every wavelength shapes how we see the world. Train your eyes with colors and your heart with kindness.

May peace, harmony, and love spread across every spectrum of humanity.

In a mouse model of Primrose syndrome, rhEPO reverses. This is preclinical & could be the first tangible therapeutic path.

Huge thanks to Justus, @cakirumut.bsky.social , Klaus and Hannelore and to an amazing team.

DOI: 10.1172/jci.insight.200021

#RareDisease #Neurobiology #TranslationalResearch

Stranded due to airspace closures. Major grant + revision deadlines piling up.

War reaches far beyond borders — even those who think they’re uninvolved feel it.

And yet this inconvenience is nothing compared to what others are enduring.

Please choose peace. Humanity first.

Suggesting a potential therapy for these autism-related symptoms and intellectual disability…

This issue’s Cover features work by Hannelore Ehrenreich & team on the improvement of Primose syndrome traits in mice following erythropoietin treatment: doi.org/10.1172/jci....

So thrilled to have our research as a cover feature at @insight.jci.org, showing recombinant human Erythropoetin can compensate for the loss of function caused by the genetic mutation.
I hope this research will age well.
Thanks Hannelore, Klaus, @cakirumut.bsky.social , Justus and ex-colleagues

The $100 whole human genome sequence finally reached!
www.sandiegouniontribune.com/2026/02/19/s...

Ancient co-option of LTR retrotransposons as yeast centromeres - Nature Evolutionarily related ‘proto-point’ centromeres providing resolution to the evolutionary origins of point centromeres are identified in yeast, and comparison shows they evolved in an ancestor with re...

Our paper is now out in Nature:

“Ancient co-option of LTR retrotransposons as yeast centromeres”

www.nature.com/articles/s41...

A short thread on how retrotransposons helped give rise to yeast point centromeres.

1/14

Phenomenal story, journey and a great thread. Thanks for sharing. Kudos to the entire team.

Thanks a lot 🙏, I can't wait to see you!

Many Congratulations @retrogenomics.bsky.social , very well deserved and well earned. 🙏🏽

I love these recipes 🤗

Such a great award and the reward too. Very well deserved @m-vincendeau.bsky.social , Many congratulations and hopefully many more to come ☺️
Keep cementing the #TEsky up above and high.

Incredible article and resource too. Congratulations @kaessmannlab.bsky.social

🙏 Thanks a lot Marianne. It was totally my pride and pleasure

Lucky you 🤗🤗

Gave a talk at @institutcurie.bsky.social on Friday and honestly… it felt unreal. Speaking in the same place where Marie Curie carried out her radiation experiments reminds how long science lasts beyond us.
Thnks Elena Zueva, @mburbage.bsky.social , Sebastian Amigorena, Josh Waterfall and Lorena 🙏🏽

Can’t wait Mariana. You’ll rock here

Congratulations and all the best

Psoriasis: Unraveling the Causes of Chronic Itching In psoriasis and other inflammatory skin diseases, chronic itching or pruritus is a particularly distressing symptom for patients which remains difficult to treat today. Scientists at the Institut Pas...

🧠🧬 Psoriasis: Unraveling the Causes of Chronic Itching

@belkaidlab.bsky.social and Institut Pasteur researchers show that an excessive immune response to skin microbes activates the IL‑17A pathway in nerves, leading to chronic itch and nerve regrowth.

👉 www.pasteur.fr/en/home/rese...

Thanks, it was so much fun 🙏

🦠 Closing our session is @manusingh.bsky.social discussing the "Long Shadow of Viral Infections".
He's showing how HIV & EBV can reactivate persistent, ancient Endogenous Retroviral proteins. A powerful reminder that our genome's history still dictates our health today!🧬

Phenomenal!!

Of course! I remember Jason’s valiant effort digging into mouse TEs. Super happy to see it out finally 🙏🏽🙏🏽

#TESKY 🎉 Phenomenal work! After the humans, the variety of mouse immune cell systems also co-opts transposon-derived enhancers/promoters. Big Kudos to Jason, Andrew Grimson, and @cedricfeschotte.bsky.social

#neuroscience #brainresearch #institutimagine #natureneuroscience #neurodevelopment #genetics | Institut Imagine Does a neuron’s "address" define its function? 🧠 We are thrilled to share a new study published in Nature Neuroscience—also featured in Le Figaro—that challenges long-standing assumptions about how t...

Does a neuron’s "address" define its function? 🧠
Featured in @lefigaro.fr, new nature neuroscience research from Denis Jabaudon & colleagues shows that misplaced neurons can work perfectly & process senses. Brain structure ≠ function!
For more information: www.linkedin.com/posts/instit...

Btw! #Umut has joined bluesky with ID @cakirumut.bsky.social

Finally, to cross-validate - Independent TF ChIP-seq shows neurogenic TFs (FOXG1, NEUROD1/2, NEUROG2, ASCL1) selectively bind TE-derived sequences, thus supporting a model where EPO engages a transposon-based regulatory reservoir to drive adult neurogenesis.🧵8/8

Here’s the twist we’re most excited about:
A sizeable fraction of EPO-responsive regulatory elements overlaps ancient transposable elements (LINEs/SINEs). These aren’t “genomic fossils” but they behave like reusable regulatory modules the brain can recruit during plasticity. 🧵7/8

The most striking effect sits in newly formed / immature pyramidal neurons.
EPO preferentially boosts accessibility and gene programs that look like a neurogenic push plus synaptic integration
🧵6/8

The strongest remodeling concentrates in excitatory neuronal lineages in dentate gyrus, with distinct responses across glia and neuroimmune compartments. This is why bulk approaches miss the story 🧵5/8