Research | Lekkos et al. show that a metabolic switch towards oxidative phosphorylation is required for cardiomyocyte re-differentiation and heart regeneration after injury in fish.
doi.org/10.1038/s441...
rdcu.be/eJ3sB
Last week's spooky creations, courtesy of IDRM's Mommersteeg Group, were carved just in time for Halloween! @tillymommersteeg.bsky.social
New research led by @klekkos.bsky.social and @tillymommersteeg.bsky.social at the IDRM and DPAG has uncovered an essential role for oxidative metabolism in heart regeneration.
Read the full paper here: www.nature.com/articles/s44...
Read the overview of the study: tinyurl.com/2syythet
Why does it matter? As oxidative metabolism is the predominant energy-producing pathway in the human heart, our work paves the way for the identification of targetable pathways to prevent heart failure.
Upregulation of oxidative metabolism through mdh1ab and malate-aspartate shuttle leads to increased cardiomyocyte re-differentiation, after proliferation has ceased. This response is conserved in the regenerative A. mexicanus surface fish but absent in the non-regenerative cavefish.
#zebrafish #regeneration #heart #OXPHOS #devbio #differentiation
@natcardiovascres.nature.com @idrm.ox.ac.uk @oxforddpag.bsky.social
Do zebrafish regenerate their hearts equally? In our new paper at the @tillymommersteeg.bsky.social lab we uncovered variations in the regenerative response of 7 wt zebrafish strains leading us to identify a critical role of oxidative phosphorylation in long-term heart regeneration.
rdcu.be/eI1v5
Photo shows an image of someone receiving a certificate. There is a lecturn on the right with a figure next to it holding a sheet of paper. The figure is smiling and walking towards the camera. To the left are a row of 4 people mid-clap standing in front of a screen where the words 'Awards Ceremony and Close) are partially visible. The photo is framed with two microscopy images - the left hand side is red and white on a black background, the right hand side has cells imaged in greens, blues and white on a black background. At the bottom of the frame is the logo for the Institute of Developmental & Regenerative Medicine.
🎉 Congratulations to Konstantinos Lekkos, a 2nd year DPhil student in the Mathilda Mommersteeg Group. Kostas won first prize at this year’s Oxford MRC-DTP Symposium with his talk on a novel discovery in zebrafish metabolism and heart regeneration. @oxforddpag.bsky.social
Square image with a background designed to look like lined note paper. Title reads as Featured Member. On the right is a faux polaroid photo of the featured member, Konstantinos Lekkos, with his name below his image. On the left are three bullet points that state 1. his job role of DPhil Student, 2. he is a member of the Mommersteeg Group, and 3. his research focus which is the role of oxidative metabolism in zebrafish heart regeneration. A dark blue band stretches across the bottom of the square to highlight a white Institute of Developmental & Regenerative Medicine logo.
👋Meet Konstantinos Lekkos, a DPhil Student in the Mommersteeg group, and our most recent featured member.
Kostas' research focuses on the role of oxidative metabolism in zebrafish heart regeneration.
Find out more about his research: www.linkedin.com/feed/update/...
@oxforddpag.bsky.social
Thank you Prof Noble for giving an astonishing lecture yesterday @oxforddpag.bsky.social! We hope you enjoyed this precious opportunity to discuss with Prof Noble.
Next we will have Dr. Xin Zhou on June 17th at 4PM. Stay tuned!
Photos taken by Dr Sung Hee Kim, voices of Oxford.
Our first seminar of the term will be delivered by Prof Denis Noble on "The pacemaker channels of the heart: from reductionism to systems biology" this week, on Wednesday the 4th of June at 4pm at the Sherrington Library. As always, a drinks reception will follow for discussion.
Excited to share our preprint! We show that sustained macrophage and B cell responses are essential for heart regeneration in Mexican cavefish, helping uncover why surface fish heal but cavefish scar 🫀🐟. Check out the full story:
www.biorxiv.org/content/10.1...
Additionally, we aim to connect students with an interest in the heart sciences through social events. We also organise outreach activities in order to promote awareness for the cardiac sciences in the wider community.
The Heart Rhythm Club is a student-run society providing a platform for students to explore the various aspects of cardiovascular sciences through seminars and discussions with world-leading scientists.
Paper alert! Congrats to Lara, @cmdooley.bsky.social , @douglasadamoski.bsky.social and Thomas Juan for their great work on identifying the first example of Transcriptional Adaption in humans!🎉
