Jose Espejo Valle-Inclan

And a great comms piece as usual by @ebi.embl.org

SAVANA is out in the wild 🦁! #SAVANA detects haplotype-resolved somatic structural variants (SVs), copy number aberrations, and calculates tumour purity and ploidy using long-read data. Together with it, a robust, data-driven benchmarking effort! Below is a thread with all the advantages 👇

MYC ecDNA promotes intratumour heterogeneity and plasticity in PDAC - Nature In a model of pancreatic ductal adenocarcinoma, extrachromosomal DNAs are shown to be a source of high-level focal amplification driving MYC heterogeneity and phenotypic adaptation.

Nature research paper: MYC ecDNA promotes intratumour heterogeneity and plasticity in PDAC

https://go.nature.com/41IPJwX

🧬 Novo estudo da #UniversidadeDeVerona, @uofglasgow.bsky.social & @champalimaudf.bsky.social revela como o #DNAExtracromossómico (#ecDNA) ajuda os tumores pancreáticos a resistirem aos tratamentos e a sobreviverem.
🔍 O resumo 👉🔗 shorturl.at/iJF8J
📄 O artigo 👉🔗 bit.ly/4ipKRUA

Loss–Translocation–Amplification Chromothripsis Drives Osteosarcoma Evolution Main Finding: High-grade osteosarcomas frequently exhibit a loss–translocation–amplification (LTA) pattern of chromothripsis that inactivates TP53 and amplifies oncogenes.Concept: Ongoing chromothrips...

🧬 #ResearchWatch: Loss–Translocation–Amplification #Chromothripsis Drives #Osteosarcoma Evolution, a summary of the study by @jevalleinclan.bsky.social, Solange De Noon, Adrienne Flanagan, Isidro Cortes-Ciriano, and colleagues @ucl.ac.uk @ebi.embl.org @uclnews.bsky.social

doi.org/10.1158/2159...

Descubierto un terremoto en el ADN que provoca un cáncer agresivo en niños y adolescentes Un equipo de científicos revela el mecanismo del osteosarcoma, un tumor que se extiende desde los huesos: “Hay cromosomas que son como Frankenstein”

Un equipo de científicos revela el mecanismo del osteosarcoma, un agresivo cáncer que afecta a niños y adolescentes y que se extiende desde los huesos: “Hay cromosomas que son como Frankenstein”

Researchers uncover what drives aggressive bone cancer Study identifies a novel mechanism driving osteosarcoma and provides insights to help predict patient outcomes.

Osteosarcoma, an aggressive bone cancer, most commonly affects children and young adults.

New research solves the mystery of what drives the genomic rearrangements causing the aggressive development and evolution of osteosarcoma tumours.

www.ebi.ac.uk/about/news/r...
🧪

Expand your Bluesky network with R Find people followed by the people you follow, but who you don't follow, using R and the atrrr package

Expand your Bluesky network with R: Find people followed by the people you follow, but who you don't follow, using R and the atrrr package blog.stephenturner.us/p/expand-you... #Rstats

Our impact We provide open data that helps scientists understand life and that informs solutions to real-world problems, such as infectious diseases, climate change and food security.

Not enough bioinformatics in your Bluesky feed? We’ve got you covered. Follow us for our latest news, exciting life science research, updates from our data resources, new tools and training resources.

Haven't heard of EMBL-EBI? Take a look at what we’re working on. www.ebi.ac.uk/about/our-im...

Portugal is rapidly losing its young people. Will this new scheme convince them to stay? | Adam Almeida Studying in Lisbon, I found most of my peers were planning to emigrate. Now the government is turning to taxes to stop the brain drain In the autumn of 2018, I moved to Lisbon for a month-long course at the Universidade de Lisboa. I struggled to find any…

Portugal is rapidly losing its young people. Will this new scheme convince them to stay? | Adam Almeida

Something that's been bugging me for a while in bioinformatics data analysis is this overreliance on packages, workflows and what's been called "cargo cult science".

Can we have more conceptual thinking, more theory?
Asking for what we really want to achieve and what we need to do gets us there.

PhD Fellowships - VHIO Join us @ VHIO for a PhD! Eligibility criteria  | How to apply |  Selection process  |  Fellowships Available  |...

I want to open my Blusky by reminding that we are looking for a motivated PhD student to join our team at VHIO for a very exciting computational immuno-oncology project. Check out the position and apply! 💻🧬 #PhD #CompImmunoGenomics
vhio.net/vhio-phd-opp...