Awesome paper and super useful resource of CRISPR-based screens to identify regulators of #LipidDroplet biology under different metabolic conditions: crisprlipid.org
Final week to apply: GSO Leadership Academy 10
The GSO Leadership Academy is an interactive program designed to support researchers who want to develop leadership skills for academia and beyond.
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Application deadline: March 1, 2026
π More information: gsonet.org/foerderprogr...
Join us next Tuesday for the next @dgz.bsky.social workshop on #trafficking and EVs! Spread the word please!
Structural basis of caveolin-driven membrane bending www.biorxiv.org/content/10.6...
Lipids challenge ligands to control receptors
The behaviour of a receptor protein can be influenced by the presence of certain lipids in the membrane it is embedded in.
π buff.ly/G1Zl6cZ
Methods should be used as widely as possible, so here is our detailed lipid imaging protocol, written with @martinba99.bsky.social and Chia-Yi (Christine) Chou authors.elsevier.com/a/1mU4XHRzCb... in Methods in Enzymology. Everything you need to know to do it yourself is in there -
Triglyceride/Cholesterol Ester Ratio Encodes Lipid Droplet Size and Diversity https://www.biorxiv.org/content/10.64898/2026.01.21.700800v1
Distinct neurons, distinct functions π§ π€ Our Nature Metabolism paper (now out!) shows that separate sympathetic projections to brown adipose tissue independently control thermogenesis and glucose tolerance. Congrats Daniele Neri and team π₯³
www.nature.com/articles/s42...
With so many great reviews on LDs already out, do we need another?
Sarah @cohenlaboratory.bsky.social and I were approached by
@natrevmcb.nature.com to do a review on LD heterogeneity and inter-organelle contacts...topics in reviews, but not a focus. Fun project!
www.nature.com/articles/s41...
Happy to finally share the amazing results of our long-term collaboration with Karin Reinischβs lab on how bridge lipid-transfer proteins (BLTPs) cooperate with partner proteins to orchestrate lipid delivery. A quick thread (1/7)
www.biorxiv.org/content/10.6...
I was part of the GSO Leadership Academy in 2023 and learned a LOT! I can highly recommend to apply. Still using techniques & advices in my everyday young PI life. And the best - it comes with an amazing peer group!
I've been waiting for this Titeca et al. story from Anne-Claude Gavin's lab to come out: A systematic, comprehensive analysis of lipid transfer protein cargo selection, a truly massive undertaking. What a time to work in lipid biology. Cool stuff every few days.
www.nature.com/articles/s41...
Wow! Great story, I am looking forward to read the paper in depth. Congrats to all authors π
Thrilled to share our latest study, led by @reikatei.bsky.social, in @natchembio.nature.com! We began by asking a simple questionβhow do cells know if they have too much of a lipid in a particular membrane, and how do they respond to rectify this imbalance?
www.nature.com/articles/s41...
More info π
Registration is open for the FASEB #LipidDroplet meeting in Scottsdale, July 26-30! This is THE premier North American conference on LDs, you do not want to miss it!
Great Thread/ summary about interesting lipid related papers of 2025 π
This is great!! Thank you
To all lipid-curious cell biologists: check out this comprehensive overview of lipid-based methods by @gerryhammond.bsky.social and colleagues in @jcb.org β a school of Babel fish for #lipidtime:
rupress.org/jcb/article/...
Blog post: Just quit
Quitting projects in science is hard, but we should be doing a lot more of it.
open.substack.com/pub/arjunraj...
Researchers have identified the protein SCoR2 as a potential drug target for obesity and hepatic steatosis in studies of mice, showing that it prevents fat accumulation and weight gain.
Learn more in #ScienceSignaling: https://scim.ag/4p5KxNe
βΌοΈπ¨Hi all! The next Bioc Soc Membrane Contact Site Meeting will be in Chepstow, UK 28-30th Sept 2026. Fantastic speakers with talk slots still available. Sign up & abstract submission now open - limited spaces so register early! Hope to see you all there. Please share + RT π
Another interesting new paper showing cellular insights in caveolae mediated fatty acid uptake by Richard Lundmarks lab and @robparton.bsky.social they show caveolae -ER contact sites that might fuel fatty acids from the plasma membrane into the ER. Very exciting!
Great opportunity for a Postdoc interested in cellular high resolution imaging: amazing lab & team, amazing campus & resources! And summer times starts early in DC βοΈI can highly recommend π
β‘οΈMitochondria make ATP, the energy that powers life. But in neurons, with axons up to a meter long, how do these tiny power plants stay functional in the right places? We went looking. 1/n www.biorxiv.org/content/10.6...
Excited to share that as my group launches across Karolinska Institutet and the University of Helsinki, weβre recruiting postdocs and research assistants to study the nanoscale architecture of lipid flux using in-cell structural biology approaches, including cryo-ET and cryo-CLEM
Textbooks said neurons donβt burn fatty acids for energyπ€. Our study delivers the first in vivo demonstration that fatty acid oxidation in defined memory neurons fuels memory formation.
Closing chapter of my PhD π₯³, out today in Nature Metabolismπ₯ @natmetabolism.nature.com
Organelles do NOT have a single uniform pH.
And if you think they must, because βprotons diffuse fast,β this paper is for you.
A thread on why that assumption is wrong; and what we found instead. 𧡠1/n
copyright Palina Nepachalovich of ZML Dresden
Ups we did it again! Please mark your calender. EMBO Workshop βLipid Code to Lifeβ, taking place September 7β11, 2026, in Dresden, organized by Maria Fedorova, @lipid.bsky.social, Valerie O'Donnell, @holthuislab.bsky.social and @molcellbiophys-lab.bsky.social π₯³ Retweets = lipidlove
Thank you Rachid!
This work wouldnβt be possible without the help & support from my long-standing collaborator Martin Lehmann and his team @fmp-berlin.de and our funding sources π @chanzuckerberg.bsky.social @dfg.de @ekfstiftung.bsky.social
