David Weiss

Efflux pumps control intracellular drug-target kinetics by limiting rebinding in bacteria Efflux pumps disrupt antibiotic rebinding inside bacterial cells, amplifying multidrug resistance.

#NatMicroPicks

More than just pumps? 🦠💊

Bacterial efflux pumps not only block drug entry but also disrupt intracellular drug–target interactions by preventing repeated drug rebinding

#MicroSky

www.science.org/doi/10.1126/...

🚨 Postdoc Opportunity – Microbiota & Cancer Biology 🚨 (@LSU)
Moreira Lab seeks for enthusiastic postdoc to study microbiota–host interactions in oncology, with focus on 16S rRNA analysis, in vivo. PhD in microbiology/molecular/cell bio/oncology. Competitive salary w/exc.benefits. DM, w/CV and 3refs.

We are hiring postdocs :)

Excited to announce the upcoming 2026 Microbial Toxins and Pathogenicity GRC and GRS meeting taking place July 12 - 17, 2026 at Waterville Valley in New Hampshire. This meeting will be chaired by yours truly and co-chaired by
@sunnyshinlab.bsky.social www.grc.org/microbial-to...

Copy number flexibility facilitates heteroresistance to increasing antibiotic pressure and threatens the beta-lactam pipeline Nature Communications - Choby et al. show that dynamic increases in the copy number of preexisting β-lactamase genes in heteroresistance enables resistance of continua of cellular...

We show how bacteria can adapt to B-lactam stress by increasing the copy number of "wimpy" beta-lactamases to overcome new drugs/B-lactamase inhibitors, without de novo evolution. This threatens the beta-lactam dominated antibiotic pipeline.

Congrats @jakechoby.bsky.social and team!
rdcu.be/euijW

@jakechoby.bsky.social is a rockstar - I encourage students/postdocs looking for an amazing mentor and excited to investigate a new frontier in antibiotic resistance to join Jake at UNC to study heteroresistance and defeat superbugs!

Congrats, Jake and team on this exciting paper.

Microbial Pathogenesis & Host Response Cold Spring Harbor Laboratory Meetings & Courses -- a private, non-profit institution with research programs in cancer, neuroscience, plant biology, genomics, bioinformatics.

Alert! The abstract deadline for the Microbial Pathogenesis & Host Response meeting has been extended to July 7 meetings.cshl.edu/meetings.asp...

Thanks, Jeff!

Thanks, Sunny!

Thanks so much, Lauren! We agree and had never considered this. Big kudos to Julia who was set on investigating this question and persisted through many ups and downs.

Bactericidal antibiotic treatment induces damaging inflammation via TLR9 sensing of bacterial DNA Nature Communications - The immunologic differences induced by bactericidal versus bacteriostatic antibiotics remain unclear. Gross et al. show that, in contrast to static antibiotics, cidal...

Bactericidal antibiotics release bacterial DNA that activates TLR9, while static antibiotics do not. This can profoundly impact treatment outcome. Should clinicians consider this when choosing antibiotics to prescribe?

Amazing work by Julia Gross and collaboration with Iain Fraser!
rdcu.be/d1Phk