gouthamnarla

The protein phosphatase 2A-B56α complex regulates N-Myc degradation in neuroblastoma High-risk neuroblastoma is one of the most common and deadliest pediatric solid tumors. Proliferation, differentiation, and treatment resistance have been linked to the amplification of MYCN. Although...

The protein phosphatase 2A-B56α complex regulates N-Myc degradation in neuroblastoma - Journal of Biological Chemistry www.jbc.org/article/S002...
excited to share new research for our group identifying a novel approach to target a major driver of pediatric neuroblastoma

Molecular glue as a new therapeutic strategy in metastatic KRAS-mutant lung cancer

@gouthamnarla.bsky.social & team combined a PP2A molecular glue with RAS/MAPK inhibitors to restore tumor-suppressor activity & overcome drug resistance in mice with metastatic KRAS-driven NSCLC: buff.ly/1HzFVe5

Abstract B051: Discovery of SW-3431, a first-in-class molecular glue activator with potent and selective anti-tumor activity in PPP2R1A mutant cancers url: aacrjournals.org/mct/article/...

Mutant PP2A Induces IGFBP2 Secretion to Promote Development of High-Grade Uterine Cancer Elevated IGFBP2 secretion by uterine cancer cells with heterozygous PPP2R1A mutations supports tumor progression and confers a vulnerability to IGFBP2/IGF1R inhibition as a therapeutic approach for th...

Our new paper describing how mutations to the PP2A gene PPP2R1A drive high-grade uterine cancers is out now in this issue of Cancer Research by @theaacr.bsky.social

aacrjournals.org/cancerres/ar...

Molecular Glue Boosts PP2A, Overcoming Resistance to RAS/MAPK Inhibitors in KRAS-Mutant Lung Cancer, Enhancing Survival Rates.

by Raines B, Tseng-Rogenski S (...) Narla G et 14 al. in J Clin Invest #MedSky

👉 get more here

📖 read the article: https://www.jci.org/articles/view/193790

Exciting new finding about the role of PP2A molecular glues in overcoming resistant to broad classes of MAPK inhibitors in KRAS driven cancers
JCI - A PP2A molecular glue overcomes ras/mapk inhibitor resistance in kras-mutant non-small cell lung cancer www.jci.org/articles/vie...