Great @bigtencrc.bsky.social summit today. Advancing cancer research collaboration across the growing BigTen (now 18!) team. Honoring colleagues including Dr. Bailey and meeting new members.
Excited by this new opportunity at the Carbone Cancer Center @uwhealth.bsky.social and know Dr. Uboha will be an excellent leader of our clinical trials program! www.linkedin.com/feed/update/...
Look at Darian, research coordinator @uw Carbone presenting this trial
Excited to see this BigTen met TNBC study @bigtenplus.bsky.social published. Although primary endpt not met, addressed an important question and some interesting observations for future. link.springer.com/article/10.1...
In women with node-positive breast cancer whose nodes became free of disease after neoadjuvant therapy, regional nodal irradiation did not reduce breast cancer recurrence or improve survival. Full results from a phase 3 trial: nej.md/4dM6LjD
#MedSky #Oncology
Key take homes for #breastcancer at #ASCO25 (3)
*Triplet PI3k (Inavo)+fulv+palbo improved OS in MBC in those with early progression on adjuvant AI (need early NGS for PIK3CA
*TDXd (plus pertuz) improves PFS in 1L HER2+ MBC. Will watch for PFS2/OS in future. Key ? is how to integrate PATINA in ER+
Key take homes for #breastcancer at #ASCO25 (2)
*1st PROTAC (vepdeg) improves PFS in mESR1 MBC
*Monitoring ctDNA for ESR1 mutations in MBC w early change to SERD (cami) improves PFS, longer term outcomes important
*Dose escalation of abema improves tolerance (TRADE)
Key take homes for #breastcancer at #ASCO25 (1)
*OFS/AI in high risk preM women reduced recurrence. OS not met (at 15 yrs) but w/o detriment to non-cancer OS
*Vasomotor AEs from ET effectively reduced w elinzanetant
*Select stage 1-3 HER2+ BC may not need carbo
*SG + pembro is a new 1L TNBC option
What a great surprise from the breast med onc clinic team today! Made my day-so thoughtful.
Meet Mahua Dey — neurosurgeon, scientist and innovator at @uwmadison.bsky.social. She's leading the charge against glioblastoma, one of the deadliest brain cancers. Her lab's personalized therapeutic vaccine, GIFT-7, has shown remarkable success in preclinical trials.
Former Univ of Wisconsin heme/onc fellow!!
Just talked about these results with 2 pts in 2 weeks. Improved outcomes with ET in ERlow breast cancer, unless pCR to Neoadj chemo. ascopubs.org/doi/10.1200/...
NIH layoffs delay research benefiting cancer patients, and celebrity cancer news is often missing important information, and more news from Cancer Today magazine: www.cancertodaymag.org/cancer-talk/...
Loving the @uwhealth.bsky.social Carbone Cancer Center Community day for @uwbadgers.bsky.social science days. Attempted Brain surgery (sticking to med onc), attended panel on working w research advocates, ice cream and more!
US map via scienceimpacts.org visualization of economic loss due to IDC cuts to 15% as part of Feb 7, 2025 executive order, with shading denoting intensity of cuts.
Working with an interdisciplinary team, we have developed a website to communicate how the White House's proposed cuts to health research would cause losses of $16B and 68,500 jobs.
Find out how your community may be impacted.
Explore more at SCIMaP: scienceimpacts.org
a 🧵
The resignation letter should be seen by all. A reminder to keep speaking up/advocating for science.
Had a great team dinner with these amazing @uwhealth.bsky.social breast nurses, MAs, pharmacists, APPs and oncologists last night! Fills the cup. @marina-sharifi.bsky.social
What a great day at our 2025 retreat- celebrating and socializing with colleagues and planning for the upcoming year. @marina-sharifi.bsky.social @noelleloconte.bsky.social @joshlangmd.bsky.social
Now online in Cancer Discovery: High-Purity Circulating Tumor Cell RNA Sequencing Identifies #ProstateCancer Lineage Phenotypes Prognostic for Clinical Outcomes - by Marina Sharifi, Jamie Sperger, Shuang Zhao, Joshua Lang, and colleagues doi.org/10.1158/2159...
Thanks to the outstanding Heme/Onc and Hospice and Palliative Medicine fellows who are committed to high quality care and ongoing learning! @uwhealth.bsky.social
This work is fundamental to advancing how we diagnose, prevent and treat the diseases the impact all of us. I hope everyone advocates for this funding to be re-instated.
Publication by @ascocancer.bsky.social on academic medical oncology. Makes me wonder- how do we encourage more transparency among institutions to set these standards ? ascopubs.org/doi/10.1200/...
Grateful to @uwbadgers.bsky.social women’s basketball team for hosting #breastcancer survivors and researchers at the game this weekend!
Moody lab pic of me in a grim piece on this wrecking ball for biomedical research. To explain “indirects": If research is a restaurant, direct costs cover ingredients & cooks' wages. Indirect costs cover kitchen, light & heat, furniture, bookkeeper etc. Lose one, the other follows!
wapo.st/3Q9DrIH
Last but not least, Dr. Sharifi presenting on Genomics/Precision Medicine #SABCS24 abstracts. @uwhealth.bsky.social
What a great day of #SABCS24 @sabcs.bsky.social updates in Wisconsin co-hosted by UWCarbone, MCW and WI Association of Heme/Onc.
Excellent #SABCS updates by Drs. Gradishar and @rmoregan.bsky.social at the 8th (or 10th?) Annual WI conference. Enjoyed catching up and grateful for these mentors and friends.
Dr. Bethany Anderson eloquently presents #SABCS24 radiation abstracts at the WI Best of SABCS. Key theme is individualization based on cancer features and pt preferences. @uwhealth.bsky.social
Dr. Anna Beck from @uwhealth.bsky.social discusses @sabcs.bsky.social surgery abstracts at the WI annual update. Great to see individualization of surgery to de-escalate when appropriate
