Shane Liddelow's Avatar

Shane Liddelow

@liddelowsa

Neuroscientist and glial aficionado at NYU Grossman School of Medicine/NYU Langone Health in NYC. Posts in my individual/personal capacity. My lab is full of awesome people doing amazing stuff - check them out: www.liddelowlab.com he/him

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07.10.2023
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Latest posts by Shane Liddelow @liddelowsa

You WISH it had a glia @stephenmath!
The combination of astrocyte and tardigrade would be a force for good!
(plus interneurons are just glial support cells right?)

11.12.2025 00:16 πŸ‘ 1 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
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The regulatory code of injury-responsive enhancers enables precision cell-state targeting in the CNS - Nature Neuroscience Zamboni et al. reveal how enhancers encode cell-type-specific responses to CNS injury. By combining multiomic profiling, deep learning and in vivo screening, they uncover injury-responsive enhancer lo...

AMAZING PAPER ALERT!
www.nature.com/articles/s41...

congratulations to @margheritazamboni.bsky.social, @ellorens.bsky.social, and the rest of the team.
This one is important and opens up lots of opportunityes.

02.12.2025 20:00 πŸ‘ 16 πŸ” 5 πŸ’¬ 1 πŸ“Œ 0

Read about one of the fantastic postdocs in the lab - @pryprk.bsky.social.
Thanks to The Scientist for running this exciting series!

Priya is on the job market atm - so keep your eyes peeled for exciting things to come from her lab soon! :-)

02.12.2025 02:56 πŸ‘ 12 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
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#SfN #SocietyForGlia #Astrocytes

ENDING STRONG in Astrocyte land here in San Diego.
Thanks for being an amazing community, and apologies (one last time) for anyone I missed! Please comment below with extra awesome astrocyte sessions.

See you in 2026!

19.11.2025 17:39 πŸ‘ 8 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0
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#SfN25 #SocietyForGlia #Astrocytes

penultimate astrocyte sessions for 2025 - let's do this!

19.11.2025 13:42 πŸ‘ 5 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

PREPRINTS ON THEIR WORK:

Priya - www.biorxiv.org/content/10.1... and www.biorxiv.org/content/10.1... (press - www.npr.org/2024/10/07/n...)

Melissa - www.biorxiv.org/content/10.1... (press - www.thetransmitter.org/astrocytes/a...)

18.11.2025 20:58 πŸ‘ 2 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0
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#SfN #SocietyForGlia
STARTING NOW!

Ending strong with the last www.liddelowlab.com presentations of the week.

@pryprk.bsky.social
talking about a world first mouse model for XDP... and OLIGODENDROCYTES!

@melcooperphd.bsky.social
presenting on astrocyte networks in the mouse forebrain.

18.11.2025 20:58 πŸ‘ 11 πŸ” 4 πŸ’¬ 1 πŸ“Œ 0

PREPRINTS ON THEIR WORK:

Priya - www.biorxiv.org/content/10.1... and www.biorxiv.org/content/10.1... (press - www.npr.org/2024/10/07/n...)

Melissa - www.biorxiv.org/content/10.1... (press - www.thetransmitter.org/astrocytes/a...)

18.11.2025 20:51 πŸ‘ 0 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
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#SfN25 #SocietyForGlia #Astrocytes

IT'S A BIG DAY - if you're unsure what do do this afternoon - it seems just going to poster row C is the best way to spend some time!

as always, apologies to those I have missed - please comment below with more sessions and presentations!

18.11.2025 16:02 πŸ‘ 3 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
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IT'S A BUSY AFTERNOON FOR THE LAB!

@mrodea.bsky.social - astrocyte chromatin in reactive astrocytes across the forebrain

Nick Kathman - COCKROACH BRAIN ALERT! (is this the largest single cell atlas of an insect brain?)

@liddelowsa.bsky.social - multiomic approaches to study astrocyte reacitivity

17.11.2025 20:38 πŸ‘ 7 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0
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It's a packed day for our researchers at #SfN25. Come say hi!

17.11.2025 16:52 πŸ‘ 4 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0
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Astrocytes and oxytoxin - we got you! NOW!

#SfN25 #SocietyForGlia #Astrocytes

17.11.2025 16:11 πŸ‘ 3 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

Argh! Sorry! THANKS!
There's so many today (and we all know the app is horrible 🫠)

17.11.2025 15:10 πŸ‘ 1 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
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#SfN25 #SocietyForGlia #Astrocytes

Monday is a BUSY day - see you all out there!
(apologies for anyone's presentation I missed - please comment below with details)

17.11.2025 14:44 πŸ‘ 5 πŸ” 1 πŸ’¬ 1 πŸ“Œ 0
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#SocietyForGlia #SfN25 #Astrocytes

Sunday is a rest day for astrocytes it seems - but still lots of cool stuff to go and see.
Apologies again for anyone I missed - please link your presentations below

16.11.2025 15:32 πŸ‘ 11 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
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#SocietyForGlia #SfN25 #Astrocytes

Astrocyte presentation round up for Day 1.
Sorry if I missed anyone, please comment below with others!

See you about the conference

15.11.2025 20:35 πŸ‘ 10 πŸ” 2 πŸ’¬ 1 πŸ“Œ 0
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#SfN25 #SocietyForGlia #Astrocytes

@borderbiologist.bsky.social presenting now!
Come and learn about a new function for a substate of reactive astrocytes - antigen presentation!

15.11.2025 20:33 πŸ‘ 13 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0
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Advances in the genetics and pathology of Lewy body dementia Lewy body dementia is a heterogeneous disease that is underdiagnosed and poorly understood. Pathologically, Lewy body dementia is characterised by the…

Very happy to have contributed to this new review on Lewy body dementia in @thelancetneuro.bsky.social led by Sonja W. Scholz. We highlight the latest advances in genetics and pathology. @liddelowsa.bsky.social Check it out! www.sciencedirect.com/science/arti...

13.11.2025 00:56 πŸ‘ 14 πŸ” 5 πŸ’¬ 0 πŸ“Œ 0

In case you were wondering what to do with precisely 150 minutes of your existence @sfn.org #SfN25 #SanDiego. Join our mini-symposium Single-Cell Multiomics in CNS Injury and Recovery. Guaranteed to contain many glial cells and at least a neuron. I am Co-chairing with Naomi Habib

11.11.2025 17:14 πŸ‘ 10 πŸ” 5 πŸ’¬ 0 πŸ“Œ 0
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(bonus)
thanks to the amazing @droligo.bsky.social and @amygleichman.bsky.social the social aspects of glial biology will be strongly represented.
(thanks also to @plasmidsaurus.bsky.social & Avantor for supporting our community!)

10.11.2025 16:43 πŸ‘ 7 πŸ” 2 πŸ’¬ 0 πŸ“Œ 0

(1/2)
preprints:

@melcooperphd.bsky.social - astrocyte networks pubmed.ncbi.nlm.nih.gov/40777296/

@mrodea.bsky.social - single cell analysis & diversity www.biorxiv.org/content/10.1...

@pryprk.bsky.social - XDP www.biorxiv.org/content/10.1..., www.biorxiv.org/content/10.1...

See you in San Diego

10.11.2025 16:43 πŸ‘ 5 πŸ” 2 πŸ’¬ 1 πŸ“Œ 0
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@sfn.org #SfN25 #SanDiego starts this Saturday. The lab is going to be there in full force - see our presentations below.
Represented this year by @borderbiologist.bsky.social, Nick Kathman, @mrodea.bsky.social, @melcooperphd.bsky.social, @pryprk.bsky.social, @kerrylimberg.bsky.social.

(1/2)

10.11.2025 16:43 πŸ‘ 50 πŸ” 17 πŸ’¬ 1 πŸ“Œ 4
A flyer displaying the same information as written in the post, with two images of two astrocytes around a blood vessel and one newly formed oligodendrocyte, along with logs our sponsors Avantor and Plasmidsaurus.

A flyer displaying the same information as written in the post, with two images of two astrocytes around a blood vessel and one newly formed oligodendrocyte, along with logs our sponsors Avantor and Plasmidsaurus.

If you are attending #SfN25, please join @amygleichman.bsky.social and I on Monday at 9PM for a casual social gathering to discuss all things non-neuronal!

Date: Monday, Nov 17th
Time: 9PM till close
Location: The Smoking Gun SD, 555 Market St.

All welcome, please free to spread the word!

29.10.2025 14:57 πŸ‘ 40 πŸ” 12 πŸ’¬ 1 πŸ“Œ 2
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Spatial dynamics of brain development and neuroinflammation - Nature A tri-omic atlas of the mouse brain from postnatal day 0 to P21 reveals that layer-specific projection neurons have a role in coordinating axonogenesis and myelination.

Our latest collaboration with @rongfan8.bsky.social, spatial triomics to investigate myelin and cortical brain development, and demyelination, spearheaded by Leslie Kirby in our lab @ki.se and Di Zhang in Rong's lab! Check it out @nature.com

www.nature.com/articles/s41...

05.11.2025 16:03 πŸ‘ 78 πŸ” 26 πŸ’¬ 5 πŸ“Œ 2

Oligodendrocytes support functional development of subcortical premotor neurons and navigation https://www.biorxiv.org/content/10.1101/2025.11.01.686017v1

02.11.2025 10:15 πŸ‘ 4 πŸ” 2 πŸ’¬ 0 πŸ“Œ 1

We've been doing some amazing stuff outside the astrocyte realm.
Check out our latest Oligo investigation led by @pryprk.bsky.social !

24.10.2025 16:40 πŸ‘ 19 πŸ” 3 πŸ’¬ 0 πŸ“Œ 0
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Astrocyte networks are much larger than previously thought, which β€œflips the way we think about astrocytes and what their networks may mean,” says @liddelowsa.bsky.social.

By @callimcflurry.bsky.social

#neuroskyence

www.thetransmitter.org/astrocytes/a...

04.09.2025 20:50 πŸ‘ 33 πŸ” 11 πŸ’¬ 0 πŸ“Œ 0

thanks for the great insights!

03.09.2025 13:51 πŸ‘ 2 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0
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Astrocyte networks span large swaths of brain The networks are plastic, connect brain regions that aren’t connected by neurons and may enable long-distance communication between astrocytes, a new preprint shows.

Great story in the @thetransmitter.bsky.social today by
@callimcflurry.bsky.social. It was fun chatting about @melcooperphd.bsky.social's new research on astrocyte networks.

Read the story here: www.thetransmitter.org/astrocytes/a...

Read the preprint here: www.biorxiv.org/content/10.1...

03.09.2025 13:39 πŸ‘ 22 πŸ” 7 πŸ’¬ 0 πŸ“Œ 0
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A fantastic time with an excellent group of trainees at the @neurochemistry.org Advanced School.
Let the conference begin!

18.08.2025 02:28 πŸ‘ 14 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0