Jinwei Zhang Lab

Specificity and mechanism of the double-stranded RNA-specific J2 monoclonal antibody Double-stranded (ds) RNAs are major structural components of the transcriptome, hallmarks of viral infection, and primary triggers of innate immune responses. The J2 monoclonal antibody is the gold-st...

Where and how to find fantastic new #RNAs? The J2 antibody is the gold standard to detect, map & enrich dsRNAs. Co-led by @bounaderlab.bsky.social, Kevin Juma, Ankur Bothra & Steve Leppla’s lab, we visualize how J2 recognizes dsRNA and define its epitope, specificity & bias. doi.org/10.1101/2025...

Harnessing Molecular Recognition for Small‐Molecule‐Mediated Reversible Photochemical Control Over mRNA Translation A small molecule ligand undergoes traceless, reversible photocrosslinking to PreQ1 RNA aptamer in a selective manner, dependent on both the RNA sequence/structure and ligand chemical structure. A cag...

Hey, check it out - new work from the lab! We report the design of design traceless, reversible small molecule photocrosslinking probes that can be used to photochemically control the translation of mRNAs just using molecular recognition! Congrats to all! onlinelibrary.wiley.com/doi/10.1002/...