Juandi Hernández

New preprint out on bioRxiv!

www.biorxiv.org/content/10.6...

Can conjugative plasmids be used to control plasmid and pathogen spread?

Follow me down the rabbit hole that led to this story 🧵

Cow Tools!

We have lived alongside cows for nearly 10,000 years.
We breed them and exploit them

It is now, only now, that we have discovered THEY CAN USE TOOLS

Here I describe our study

(paper) www.sciencedirect.com/science/arti... in @currentbiology.bsky.social
with @auersperga.bsky.social

Mutant CHCHD10 disrupts cytochrome c oxidation and activates mitochondrial retrograde signaling - EMBO Molecular Medicine Mutations in CHCHD10, a mitochondrial intermembrane space (IMS) protein implicated in proteostasis and cristae maintenance, cause mitochondrial disease. Knock-in mice modeling the human CHCHD10S59L va...

link.springer.com/article/10.1... (3/3)

has just been published in EMBO Molecular Medicine @embomolmed.org @embo.org. Special congratulations to Timothy and all the good people involved in this work. I am happy to be part of this project @pasteur.fr @devstempasteur.bsky.social (2/3)

Great news after the Christmas break! The work showing that CHCHD10 causes mitochondrial cardiomyopathy by disrupting intermembrane space proteostasis, impairing cytochrome c–dependent bioenergetics, and triggering maladaptive mtISR signaling—led by Márcio, a lab mate of mine— (1/3)

Good morning all! Here is the last weekly issue of the year in #cancermetabolism and #mitochondrialbiology to accompany your readings! biomed.news/bims-camemi/... @biomednews.bsky.social #keepreading

"It is a serious thing, just to be alive on this fresh morning, in the broken world."-Mary Oliver

🆕 New update! Young Investigators Day will take place the day before EUROMIT 2026.

Don’t miss this unique chance for young scientists to connect and present your work !

👉 www.euromit2026.eu/article/youn...

#EUROMIT2026 #MitochondrialDisease #mtDNA #mitochondria

Measuring mitochondrial membrane potential | The EMBO Journal EMBO Press is an editorially independent publishing platform for the development of EMBO scientific publications.

Measuring mitochondrial membrane potential | The EMBO Journal www.embopress.org/doi/full/10....

The Friday crème brûlée is back! @institutpasteur.bsky.social

Last week, I had the great opportunity to present my postdoc project as a talk at the EMBO–FEBS meeting in Belgrade, Serbia. This work is being carried out at the Institut Pasteur @pasteur.fr. Grateful to the organizers for this inspiring and insightful event @embo.org bo.org @febspress.bsky.social

Professeure Yasmine Belkaid, Directrice Générale de l'Institut Pasteur depuis janvier 2024. ©Institut Pasteur / François Gardy

🔬 "La science n'est pas une affaire d'opinion personnelle !"

Yasmine Belkaid, Directrice générale de l'Institut Pasteur, dénonce le démantèlement de la recherche US et réaffirme le rôle crucial de la science face aux défis sanitaires mondiaux.

↘️ www.lesechos.fr/idees-debats...

© Institut Pasteur

🟢 The Institut Pasteur goes green for Mitochondrial Disease Awareness Week! 🟢
These rare diseases affect 1 in 5,000 people. Mitochondria, the “powerhouses” of our cells, are also thought to play a role in Alzheimer's disease.
Research today, cure tomorrow. 🔬 #WorldMitoWeek2025

Mitochondria protect against an intracellular pathogen by restricting access to folate As major consumers of cellular metabolites, mitochondria are poised to compete with invading microbes for the nutrients that they need to grow. Whether cells exploit mitochondrial metabolism to protec...

Mitochondria protect against an intracellular pathogen by restricting access to folate | Science www.science.org/doi/10.1126/...

"I think that in Europe there is a better balance than in other places in terms of life, personal life and professional life."

Nicolás Rascovan, Argentinian researcher at @pasteur.fr, Paris.

#ChooseEuropeForScience

Here we go—ready for another adventure! 👨🏻‍🔬🧫

Beautiful cartoons on the grids of the Institute illustrating our future research centre on vector-borne diseases @pasteur.fr with lovely #trypanosomes and a tsetse fly 😉
Many thanks to Céleste Gangolphe for the exceptional work!

Cómo resolver las limitaciones de las CRISPR para editar el genoma de las mitocondrias - Gen-Ética La microbióloga Lynn Margulis pasará a la historia de la biología por haber propuesto la teoría endosimbiótica del origen de las células eucariotas (las que forman el cuerpo de levaduras, […]

He convertido la reacción que preparé para @sciencemediacentre.es a este artículo en @plosbiology.org sobre propuestas innovadoras terapéuticas con nuevos editores de bases para enfermedades mitocondriales en entrada en mi blog #gen_ética en @naukas.bsky.social
montoliu.naukas.com/2025/06/29/c...

Reactivation of mammalian regeneration by turning on an evolutionarily disabled genetic switch Mammals display prominent diversity in the ability to regenerate damaged ear pinna, but the genetic changes underlying the failure of regeneration remain elusive. We performed comparative single-cell ...

www.science.org/doi/10.1126/...

#PodcastCNRS 🎧 Saviez-vous que plus de 40 % de notre masse corporelle est composée de muscles ? 💪
La biologiste Bénédicte Chazaud étudie leur capacité de régénération et ce qui bloque le processus quand le corps est malade.

👉 smartlink.ausha.co/cnrs-qu-est-...

Complementing muscle regeneration—fibro-adipogenic progenitor and macrophage-mediated repair of elderly human skeletal muscle - Nature Communications Successful skeletal muscle regeneration involves a complex and finely tuned inter-cellular response. Here, by using spatial transcriptomics, the authors identify an intercellular communication axis be...

New #NatureComms paper: Complementing muscle regeneration—fibro-adipogenic progenitor and macrophage-mediated repair of elderly human skeletal muscle. #Myoblue tinyurl.com/yvr65vm9

Delighted that our work on positional memory is now published. We asked how axolotl cells 'know' which part of the limb to regenerate after injury.
www.nature.com/articles/s41...
A joy to work with super team Sarah Plattner, Yuka Sugiura, Francisco Falcon and Elly Tanaka.
🧵1/14

Mitochondria–membranous organelle contacts at a glance Summary: We provide an overview of contacts between mitochondria and other membranous organelles, describing the interorganelle tethers involved and the factors that regulate the composition and funct...

journals.biologists.com/jcs/article/...

Molecular machineries shaping the mitochondrial inner membrane - Nature Reviews Molecular Cell Biology The inner mitochondrial membrane forms cristae, which are crucial for mitochondrial function. This Review explores the protein complexes that regulate cristae dynamics, including remodelling and fusio...

Molecular machineries shaping the mitochondrial inner membrane

www.nature.com/articles/s41...

Molecular machineries shaping the mitochondrial inner membrane - Nature Reviews Molecular Cell Biology The inner mitochondrial membrane forms cristae, which are crucial for mitochondrial function. This Review explores the protein complexes that regulate cristae dynamics, including remodelling and fusio...

Molecular machineries shaping the mitochondrial inner membrane.

Spatial analysis of mitochondrial gene expression reveals dynamic translation hubs and remodeling in stress Quantitative imaging of the mitochondrial central dogma identifies translation hubs that are suppressed during stress.

Spatial analysis of mitochondrial gene expression reveals dynamic translation hubs and remodeling in stress | Science Advances www.science.org/doi/10.1126/...

Mitochondria-organelle crosstalk in establishing compartmentalized metabolic homeostasis Mitochondria serve as central hubs in cellular metabolism by sensing, integrating, and responding to metabolic demands. This integrative function is a…

Happy to share our most recent review on mitochondria-organelle metabolic communication with Yatrik Shah and Costas Lyssiotis now online at Molecular Cell!

We explored aspect of lipid transfer, organelle membrane contacts, ROS, metabolites, and metals!

www.sciencedirect.com/science/arti...

Impaired stem cell migration and divisions in Duchenne Muscular Dystrophy revealed by live imaging Dysregulation of stem cell properties is a hallmark of many pathologies, but the dynamic behaviour of stem cells in their microenvironment during disease progression remains poorly understood. Using t...

🔥🔥🔥 New preprint!
Our new work explores the dynamic behaviour of muscle stem cells and their niche interactions in Duchenne Muscular Dystrophy.
www.biorxiv.org/content/10.1... #MyoBlue

Interested in the plasmidverse? Then, don't think twice and join the International Society for Plasmid Biology Virtual Seminars Series. 👇

Extreme Environments: Lessons from Ocean Depths Adaptations of the Heart: Comparative Responses to Diving and Hypoxia Across Species…Many physiological mechanisms have evolved in living organisms to cope with extreme environments, including high altitudes or deep ocean depths. These include changes in oxygen transport and utilization, metabolic adjustments, strategies to retain heat in cold conditions, adaptations to withstand high pressure, mechanisms for surviving in darkness, and efficient energy use to cope with limited food availability.

What better way to kick off our BlueSky than with a deep dive into science?🌊🔬

Our latest article, Extreme Environments: Lessons from Ocean Depths, explores how whale hearts adapt to deep-sea pressures🐋

Written by Juan, postdoc at @pasteur.fr🧬

👉Read it: www.piplettes-pasteur.com/post/extreme...