SHUBHAM

Thank you so much! Excited to explore polar lobe mechanics with this amazing group 😊

New preprint:
We identify a dual regulatory role of nuclear FNBP4 in actin dynamics: the C-terminus binds actin, while the N-terminus inhibits the formin FMN1.

Thanks to @Sankar_Maiti @iiserkol, #Actin_Cytoskeleton_Dynamics_Lab

doi.org/10.64898/202...

#actin #biochemistry #nucleus #formin #fnbp4

Meeting Alert! Santa Cruz Developmental Biology Meeting! 👇 @socdevbio.bsky.social @insdb.bsky.social @bscb-official.bsky.social @isdb.bsky.social @bsdb.bsky.social @ascbiology.bsky.social

Perspective @jcb.org by Richard McIntosh describing the history of research on #microtubule polymerization in terms of the ideas, technologies, and observations that have emerged as countless researchers have studied the dynamics of these essential cytoskeletal polymers. rupress.org/jcb/article/...

Call for papers for JCS Special Issue Text: Special Issue Cell Biology of the Nucleus Guest Editor: Abby Buchwalter Deadline: 3 November 2025 Image of a cell with a heart-shaped nucleus (Image credit: Hoang Anh Le) Journal of Cell Science logo

Call for papers: Cell Biology of the Nucleus

We invite you to submit your latest research to our special issue: Cell Biology of the Nucleus, guest edited by @abbybuch.bsky.social alongside JCS Editor Megan King @luskinglab.bsky.social.
Deadline: 3 November
journals.biologists.com/jcs/pages/nu...

Nuclear protein FNBP4: A novel inhibitor of non-diaphanous formin FMN1-mediated actin cytoskeleton dynamics Formin1 (FMN1), a member of the non-diaphanous formin family, is essential for development and neuronal function. Unlike diaphanous-related formins, FMN1 is not subject to canonical autoinhibition thr...

🚨 New publication out in @jbiolchem!
We show how FNBP4 inhibits FMN1-mediated actin dynamics, revealing key regulatory mechanisms of non-diaphanous formin. Grateful to @Maiti_SP for his guidance and @ANRFIndia for funding!
🔗 doi.org/10.1016/j.jbc.…
#ActinCytoskeletonwww.jbc.org/article/S002...xt

Mechanistic Insights into FNBP4-Mediated Regulation of non-diaphanous Formin FMN1 in Actin Cytoskeleton Dynamics Formin1 (FMN1), a member of the non-diaphanous formin family, is essential for development and neuronal function. Unlike diaphanous-related formins, FMN1 is not subject to canonical autoinhibition thr...

Mechanistic Insights into FNBP4-Mediated Regulation of non-diaphanous Formin FMN1 in Actin Cytoskeleton Dynamics www.biorxiv.org/content/10.1...

Thank you for sharing. Now it is published in #jounal_of_biological_chemistry @asbmbjournals.bsky.social @asbmb.bsky.social
10.1016/j.jbc.2025.108550

Actin fell in love with nucleus ❤️

#actin #cytoskeleton #nucleus #microscopy #cellbiology #research