Ernst Lengyel

I’m proud to share our lab's latest work in collaboration with
@mannlab.bsky.social is featured on the cover of @cp-cancercell.bsky.social. The artwork illustrates the malignant progression of borderline ovarian tumors to LGSOCs.
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Read the publication: www.cell.com/cancer-cell/...

Leap onto the August issue of Cancer Cell, out now: www.cell.com/cancer-cell/...

Proud to share our new @nature.com study: We developed the 1st NNMT inhibitor that reprograms cancer-associated fibroblasts, boosting immune response & stopping tumor growth in ovarian cancer models, especially when paired with immunotherapy.

nature.com/articles/s41...

NNMT inhibition in cancer-associated fibroblasts restores antitumour immunity - Nature An NNMT inhibitor reduces tumour burden and metastasis in multiple mouse cancer models and restores immune checkpoint blockade efficacy by decreasing cancer-associated-fibroblast-mediated recruitment ...

New in @nature.com: Drs. @lengyel-ovca-lab.bsky.social, Janna Heide & co-authors discovered a first-of-its-kind NNMT inhibitor that reprograms cancer-associated fibroblasts and restores immune response in ovarian cancer. A major step toward more effective therapies.

www.nature.com/articles/s41...

🔥 Hot off the press: In a new @nature.com study, Ernst Lengyel, MD, PhD and team show that blocking NNMT in tumor-supporting cells restores immune response & stops ovarian cancer growth, offering a new strategy to treat one of the deadliest cancers. @lengyel-ovca-lab.bsky.social
ow.ly/zzfZ50Wu3UW

I’m thrilled to share that the main work of my PhD has been published @cp-cancercell.bsky.social ! With @mannlab.bsky.social & @lengyel-ovca-lab.bsky.social, we mapped the progression from borderline ovarian tumors to LGSC using spatial proteo-transcriptomics and identified new therapeutic targets.

Spatial proteo-transcriptomic profiling reveals the molecular landscape of borderline ovarian tumors and their invasive progression Schweizer et al. profile the tumor progression from non-invasive serous borderline tumors of the ovary to metastatic low-grade serous ovarian cancer. By integrating cell-type resolved Deep Visual Proteomics and spatial transcriptomics, they identify and validate several drivers of transformation as well as a novel combination treatment for this chemo-resistant disease.

Online Now: Spatial proteo-transcriptomic profiling reveals the molecular landscape of borderline ovarian tumors and their invasive progression

An interdisciplinary study uncovers how benign borderline ovarian tumors develop into invasive low-grade serous carcinoma, opening a new avenue for targeted therapy.

❕Publication: www.cell.com/cancer-cell/...

❕Press Release: www.biochem.mpg.de/when-tumors-...

Spatial proteo-transcriptomic profiling reveals the molecular landscape of borderline ovarian tumors and their invasive progression Schweizer et al. profile the tumor progression from non-invasive serous borderline tumors of the ovary to metastatic low-grade serous ovarian cancer. By integrating cell-type resolved Deep Visual Prot...

Our paper on ovarian cancer #LGSC is out in @Cancer_Cell. Using deep visual proteomics #DVP and spatial transcriptomics, we mapped how non-invasive tumors become deadly ovarian disease, and found a promising new treatment combination.
www.cell.com/cancer-cell/...

@lisaschweizer.bsky.social @mpibiochem.bsky.social @uchicagocancer.bsky.social @cp-cancercell.bsky.social

Spatial proteo-transcriptomic profiling reveals the molecular landscape of borderline ovarian tumors and their invasive progression Epithelial serous borderline tumors (SBT) are non-invasive neoplastic ovarian lesions that may recur as chemo-resistant low-grade serous cancer (LGSC)…

Proud to share our latest work in ‪#CancerCell‬ in collaboration with the @mannlab.bsky.social: we map the progression from borderline ovarian tumors to low-grade serous ovarian cancer and propose a promising new therapeutic strategy.
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www.sciencedirect.com/science/arti...

A cell atlas of the human fallopian tube throughout the menstrual cycle and menopause - Nature Communications The fallopian tube undergoes extensive cellular and molecular changes during the menstrual cycle and aging. Here, Weigert et al. present a single-cell atlas of the normal human fallopian tube revealin...

We describe a comprehensive cell atlas of healthy human fallopian tubes during the menstrual cycle and menopause using single-cell RNA and ATAC sequencing in NatureCommunication. Team work with Drs. Weigert, Li, Chen, Basu
www.nature.com/articles/s41...

We participated in a study led by Honami Naora Ph.D. from MD Anderson characterizing the role of B-cells in early ovarian cancer metastasis

“Neutrophil extracellular traps promote pre-metastatic niche formation in the omentum by expanding innate-like B cells that express IL-10”
dlvr.it/TH7nCc