The #Special #Issue on #OMICs is now out!
This work by Xu et al. presents their single cell analysis on chondrocyte composition in developmental dysplasia of the hip- a disorder that has long-term chronic pain and limited hip joint mobility.
Read moreπ
www.oarsijournal.com/article/S106...
Our #OMICs #Special #Issue features work by Jachim et al. identifying gene regulatory networks that drive human articular cartilage cell fate and establishing an in vitro model showing promise as a tool to study cartilage development and homeostasis.
π: oarsijournal.com/article/S106...
Have you heard of E1K?
This month in #OAC learn about E1K, a candidate as a disease modifying #OA drug that alleviates pain and regenerates cartilage simultaneously!
Read more from this work by Moon et al.
www.oarsijournal.com/article/S106...
How does MRI T2 mapping of articular cartilage in the knee serve as a biomarker for #OA?π§
Harlianto et al. found in a population based cohort that T2 values were associated with BMI.
Read more: www.oarsijournal.com/article/S106...
OARSI is excited to announce that NOMINATIONS are open for Publication of the Year! π€©
Research published in OAC and OAC Open since April 2025 are eligible for nomination!!!
Due March 6th!
Nominate here π: form.jotform.com/223553406964157
π€ Is there a relationship between osteoarthritis (OA)-induced neuroinflammation and neurodegenerative disorders?
π Read all about this interesting topic in this review by Prasoon et al - oarsijournal.com/article/S1063-β¦
Does #unicompartmental or #bicompartmental joint space width measures reflect whole joint structural damage better?
www.oarsijournal.com/article/S106...
The basic science #EditorsChoice for #Feb is this work by de Roy et al. Learn about the tribological impact of synovial fluid (SF) viscosity and composition during the different stages of #OA!
Read moreπ: www.oarsijournal.com/article/S106...
π³οΈβπ Sexual orientation and #OA
β° Feb's Editor's Choice by Sha et al. investigated the relationship between #sexualorientation and OA risk in LGBTQIA2S+ population
β
They found a higher risk of OA in bisexual & lesbian women but a lower risk in gay men
oarsijournal.com/article/S106...
This month in #OAC Hyodo et al. assessed the effects of imeglimin, a novel anti-diabetic agent related to metformin, on the development and progression of knee #OA.
Read more π: sciencedirect.com/science/arti...
More #Basic #Science in #OAC this work by Simoes et al. develops a #translational strategy inhibiting aggrecanase activity in #OA using TIMP-3.
Learn more π
sciencedirect.com/science/arti...
New in #OAC, Xu et al. investigates parathyroid hormone-related peptide nuclear localization segment (PTHrP-NLS) and parathyroid hormone 1 receptor (PTH1R) signal-dependent rehabilitative effects of CD90+ chondrocytes on degenerative TMJ cartilage.
oarsijournal.com/article/S106...
How do sex differences in the brainstem alter experimental #osteoarthritis ?π§
Check out this work by Rodrigues et al.
www.sciencedirect.com/science/arti...
Ziemian et al. demonstrates repetitive loading induced protective effects in the joint & attenuated OA progression over time relative to a single bout of loading even when applied at hyperphysiological load magnitudes known to initiate cartilage damage.
Read moreπ
pubmed.ncbi.nlm.nih.gov/40020990/
The January #EditorsChoice #Basic #Science in #OAC is this review by Wallace et al. Learn about the decreased risk of OA in non-industrialized societies.
Read more: www.sciencedirect.com/science/arti...
As we usher in the new year, we also wanted to celebrate the achievements of a giant in the hashtag#osteoarthritis community.
Read more about Frank's legacy and the Frank Beier Graduate Opportunity Scholarship in this month's issue here: www.oarsijournal.com/article/S106...
π₯ New year new issue!
2026's first editors choice is this large (n>500,000) cohort study on the effects of air pollution on osteoarthritis risk
Read more from Chen et al here: oarsijournal.com/article/S106...
#carbonmonoxide #nitrogendioxide #pm10
#New in #OAC Work from Chen et al. found that treadmill #exercise offers protective effects when initiated early after OA onset but may worsen outcomes if delayed.ππββοΈπββοΈ
π
oarsijournal.com/article/S106...
How does Estrogen receptor-Ξ± loss accelerate cartilage degradation? π§
#New in #OAC this month!
Read more:
www.oarsijournal.com/article/S106...
#OAC #Dec TMJ condylar cartilage exhibits a distinct hyaline microstructure compared to knee cartilage, characterized by higher cell density, smaller cells, and enlarged cell lacunae filled with GAGs, contributing to a load-responsive mechanical behavior.
π www.sciencedirect.com/science/arti...
Where does OA pain really come from? π€
December's Editor's Choice (Clinical) suggests it's NOT just the cartilage
Targeting entheses might be next frontier for symptom relief
Read more from Ziegeler et al: www.oarsijournal.com/article/S106...
#New in #OAC Xiao et al. investigates the role of CX3CR1βΊ macrophages and microglia in local inflammation and pain using transgenic mouse models and surgically induced disc herniation model.
π
sciencedirect.com/science/arti...
New in #OAC Alimy et al. identified subchondral bone endotypes with distinct clinical and cellular characteristics as a basis for developing novel OA therapies.
π
www.oarsijournal.com/article/S106...
This collaborative work from Farhat et al. seeks to learn about the brain-joint connection and reveals a CB1 dependent hypothalamic connection to the lateral meniscus that prevents its mineralization and subsequent articular cartilage damage.
π www.oarsijournal.com/article/S106...
π Editor's Choice!
This month's featured paper is on plasma #lipoprotein and #osteoarthritis risk
Lipoprotein subclasses play diverse roles in health and disease there is so much more to learn about its impact on knee #osteoarthritis
Read more from Li et al - www.oarsijournal.com/article/S106...
LAST DAY TO SUBMIT!βΊοΈ
How did Zhou et al. monitor the temporal profiling of lipid mediators in the synovium and tibial plateau during joint inflammationπ§? Learn out this work in this month's #EditorsChoice paper for #Basic #Science.
π
www.sciencedirect.com/science/arti...
One week left to submit your #Cover #Art for the #OAC cover art competition. We look forward to seeing all of the creative designs. π€©
π Are you a young researcher interested in editorial roles?
If that is you, OAC is currently seeking Editorial Fellows for 2026!
Fellows will be mentored by our Editors-in-chief David Hunter @jointsintheworld.bsky.social and our team of Deputy Editors.
form.jotform.com/242315596999...
#New research highlights the key role of the NGF/TrkA pathway in chronic #OA pain. Through gene expression analysis, specific genes and pathways linked to OA progression were found, offering insights for targeted therapies against OA pain. #PainResearch
π:
www.sciencedirect.com/science/arti...
