Felipe de Souza Leite

Thanks @mattmuscleguy.bsky.social!

Jeff is the best!

Multiomic profiling reveals that prostaglandin E2 reverses aged muscle stem cell dysfunction, leading to increased regeneration and strength Wang et al. uncover that aged muscle stem cells have blunted PGE2-EP4 signaling that is critical for their regenerative function. Treatment with exogenous PGE2 reverses age-related defects in muscle s...

New #CellStemCell paper from Helen Blau and colleagues: Multiomic profiling reveals that prostaglandin E2 reverses aged muscle stem cell dysfunction, leading to increased regeneration and strength. #Myoblue tinyurl.com/yvf4cdch

🧵5 Top Free Alternatives to BioRender for Scientific Illustrations!

These five websites offer free scientific illustrations for biologists. Great for presentations, research papers and other research communication needs.

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My Site About Me I am currently an Associate Professor in the Department of Human Health and Nutritional Sciences (HHNS) in the College of Biological Sciences (CBS) at the University of Guelph and Director...

The PowerLab ( uofgpowerlab.weebly.com ) is having some big turnover this summer and this opens the door to take on new PhD students to work on projects related to muscular adaptations to use/disuse across various structural levels.

Happy to chat!!

Muscle-specific increased expression of JAG1 improves skeletal muscle phenotype in dystrophin-deficient mice. Therapeutic strategies for Duchenne Muscular Dystrophy (DMD) will likely require complementary approaches. One possibility is to explore genetic modifiers that improve muscle regeneration and function...

I would be glad to have feedback on this. The new preprint from Kunkel lab explores Jag1 overexpression in mice dystrophic muscles. #myoblue

Dual-filament regulation of relaxation in mammalian fast skeletal muscle | PNAS Muscle contraction is driven by myosin motors from the thick filaments pulling on the actin-containing thin filaments of the sarcomere, and it is r...

This has been a long time in the making but I am absolutely delighted to share our latest paper published in
@pnas.org where we use time-resolved X-ray diffraction to elucidate the regulatory roles of the thick and thin filaments during muscle relaxation #myoblue
www.pnas.org/doi/10.1073/...

Absolutely great! Congrats!

John Gurdon on early "encouragement" from his science teacher @nobelprize.bsky.social

This is figure 1, which shows simulated contrasting precipitation responses to deforestation at different scales (0–1,000 km) over the Amazon region.

Amazonian deforestation is making wet seasons wetter and dry seasons dryer, according to research in Nature. The analysis highlights the local and regional effects of removing trees from the tropical region. https://go.nature.com/41jCClO 🧪

microRNA-133a as an indicator of disease progression and treatment response in X-linked myotubular myopathy Dowling and colleagues identify miR-133a as a non-invasive biomarker for monitoring disease progression and treatment response in X-linked myotubular myopathy (XLMTM). Their study reveals its correlat...

Happy to be a part of another great collaboration with @JimDowling for this new @MolTherapy #MTNA paper: microRNA-133a as an indicator of disease progression and treatment response in X-linked myotubular myopathy. #Myoblue. 1/n tinyurl.com/yc5bdbfe

Viva! Que alegria, Brasil!

I hope Brazil will make history tonight.

This is figure 4, which gives a comparison of working and non-working children in oral abstract and market maths word problems (study 3).

Children who learn maths working in markets and children who learn maths only from school were both unable to transfer their skills to new contexts, highlighting a need to reconsider how maths is taught in school, according to a paper in Nature. https://go.nature.com/4aXHcuu 🧪

Transcriptional adaptation upregulates utrophin in Duchenne muscular dystrophy - Nature Transcriptional adaptation upregulates UTRN in Duchenne muscular dystrophy (DMD) patients, as supported by several lines of evidence, including the use of splice-switching antisense oligonucleotides to induce the skipping of out-of-frame exons of the DMD gene.

Nature research paper: Transcriptional adaptation upregulates utrophin in Duchenne muscular dystrophy

https://go.nature.com/41bSbNq

"Imagine a DAPI-like stain, but for the extracellular matrix." That's basically how this work was pitched to me by Kayvon and Antonio a year or so ago. Now the final product really delivers. Read about their versatile label for ECM in living tissues here: www.nature.com/articles/s41...

Glissando sarcomeres in a single myofibril. 😉

A cartoon illustration of an anthropomorphic titin protein as a massive, muscular figure wearing a lab coat, glasses, and a red tie, flexing its biceps confidently. To the left, there is a text box titled "TITIN" that says: "Look at this absolute unit of a protein (appearance as hallucinated by AI): 3,800 kD, ~0.4 kg of your body, critical for heart function, mutations: most common genetic cause of heart failure." The background includes a colorful DNA helix, and a smaller version of the character appears at the bottom left.

Titin is massive in size – at 3,800kD it’s the largest protein in your body and really important for heart function.

In a new paper, led by Yuri Kim and the Seidman lab, we describe an enhancer critical for normal Titin expression.

Here is the overview (1/n)

Paper: www.jci.org/articles/vie...

Jeff is an outstanding muscle physiologist with whom I’m fortunate to work. This is an excellent study using #AI to track the swimming of dystrophic #zebrafish.

Arriving soon here!