Jörg Grandl

Beautiful new work on the force-gated ion channel Piezo2.

"Here, we measure the sensitivity of the force-gated ion channel Piezo2 and demonstrate that it is modulated by alternative splicing."

New preprint: www.biorxiv.org/content/10.6...

We are looking for a new member of the Patapoutian lab:

recruiting2.ultipro.com/SCR1003TSRI/...

Department Chair, Duke Neurobiology - Duke University, Durham job with Duke University - School of Medicine | 12852576 The Duke University School of Medicine (SOM) seeks a distinguished neuroscientist to serve as the next Chair of the Department of Neurobiology.

My department, Duke Neurobiology, is searching for a new chair. Ad below. Come work with me, @jmgrohneuro.bsky.social @ennatsew.bsky.social @jorggrandl.bsky.social @jnklab.bsky.social @sbilbo.bsky.social @neurocircuits.bsky.social and many other amazing folks! @dukemedschool.bsky.social

Structures of invertebrate PEZO-1 isoforms with a compact architecture and a dispensable pore-distal N-terminal blade PIEZO channels are mechanosensitive ion channels conserved from plants to humans, yet structures exist for only a few mammalian orthologs. We define t…

The Cordero Vásquez Lab is starting the year on a high wheel (see below) with our latest work on the C. elegans PIEZO channel: “Structures of invertebrate PEZO-1 isoforms with a compact architecture and a dispensable pore-distal N-terminal blade”: www.sciencedirect.com/science/arti...
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My lab in the NIH Intramural Program (Bethesda, MD) will be recruiting postdoctoral fellows over the next year with flexible start dates. We work on nanoscale cellular imaging of the plasma membrane and related organelles. Please reach out if you’re interested. www.training.nih.gov/jobs/pdp-053...

Congratulations!!

To all trainees interested in channels and transporters: the joint FEBS/EMBO course will go ahead in Erice, Italy from May 13-19 2026:
network.febs.org/posts/new-jo...
Further details to come soon.

Please share and repost.

PIEZO channels link mechanical forces to uterine contractions in parturition Mechanical forces are extensively involved in pregnancy and parturition, but their precise roles and mechanisms remain poorly understood. Here, we identify mechanically activated ion channels PIEZO1 a...

New preprint alert! The uterus expands ~500-fold in pregnancy, yet we know little about how pressures are sensed. Led by @yunxiao-dr.bsky.social, we show PIEZOs are required for contractions and birth in mice, with dual roles of PIEZO1 in muscle and PIEZO2 in neurons
www.biorxiv.org/content/10.1...

Nobel laureate on how Trump's cuts are hurting science Neuroscientist, biologist and 2021 Nobel Prize winner Ardem Patapoutian joined Midday Edition to talk about how the Trump administration's effort to cut back on science spending is impacting researche...

I spoke with Jade Hindmon, host of @kpbssandiego.bsky.social Midday Edition, about the consequences of the current administration’s cuts to science funding. Please share to help spread the word and raise awareness.
www.kpbs.org/podcasts/kpb...

Excited to share our latest story in Nature. We developed a high-throughput cellular stretch system to look for genes regulating membrane rupture under tension, and found an amazing small protein called NINJ1 that weakens the membrane for rupture! H/T to Zozo, my 10-y.o. for her artist's impression😃

Join us for the next SGP EpIC Seminar on Tuesday, 5 May, at 12:00 pm Eastern featuring a talk by Amanda Lewis, "Piezo1 ion channels are capable of conformational signaling." As ever, registration is free and all are welcome. sgp-epic-seminars.com

Nobel laureate: I owe America my success. Today, its scientific future is in danger | CNN Dr. Ardem Patapoutian says he watches “with deep sadness as the United States’ remarkable scientific enterprise, which took generations of hard work and national investment to build, faces a concerted...

Published an op-ed for @cnn.com: “Nobel laureate: I owe America my success. Today, its scientific future is in danger.”
A personal reflection on what’s at stake as science funding gets slashed. I’d be grateful if you could amplify both in and beyond the science world.
www.cnn.com/2025/04/09/h...

📣 📣 📣 Optically Guided Tension Clamp 📣 📣 📣

Now out: Michael Sindoni developed a new system that uses machine learning & closed-loop control to clamp membrane tension with high precision. Study your favorite force-gated ion channel!
#IonChannel #Biophysics

Read more: www.cell.com/biophysj/ful...

a cat is laying on top of the number 25 ALT: a cat is laying on top of the number 25

The Patapoutian lab started 25 years ago on March 1, 2000. A quarter-century of science with brilliant trainees, colleagues & collaborators. Cheers to my mentors & mentees! Excited to celebrate with past & present lab members in November. Here’s to more great science 🧪 and better times ahead!

Duke reduction of 25% is news to me. Do you know what programs?

The mechanosensitive channel YbiO has a conductance equivalent to the largest gated-pore Lane et al. demonstrate that the mechanosensitive channel YbiO can achieve conductances equivalent to the largest gated-pore in nature when subjected to membrane tension. Single-channel analysis shows...

In our recent article we show the YbiO mechanosensitive channel can achieve pore openings of 3nS under membrane tension equalling the largest known gated-pore MscL and we also solve a cryo- EM structure of a YbiO in a sub-open state. Great effort by @lane-b.bsky.social www.cell.com/structure/fu...

Electrosome assembly: Structural insights from high voltage-activated calcium channel (CaV)–chaperone interactions Ion channels are multicomponent complexes (termed here as“electrosomes”) that conduct the bioelectrical signals required for life. It has been appreciated for decades that assembly is critical for pro...

Glad to share a new minireview with Zhou Chen summarizing our current thoughts on how cells make electrosomes (aka ion channels).

portlandpress.com/biochemsoctr...

3) BIOPHYSICAL CHARACTERIZATION OF THE HUMAN FORCE-GATED ION CHANNEL PIEZO2.


Poster B377. Wednesday, Feb 19 10:30 AM

2) PIEZO1 ION CHANNELS ARE CAPABLE OF CONFORMATIONAL SIGNALING.


Platform. Monday, Feb 17 12:00 PM
Poster B381. Wednesday, Feb 19 10:30 AM

Our lab will be presenting 1 talk at 3 posters at the upcoming Biophysical Society Annual Meeting. If you are attending we would love to connect with you and show our work:

1) A CLOSED-LOOP SYSTEM FOR MILLISECOND READOUT AND CONTROL OF MEMBRANE TENSION.

Poster B284. Monday, Feb 17 1:45 PM

yeah - back up and running...

Yes

To catch up, I recently had the opportunity to give a seminar at Johns Hopkins - Neuroscience. How much fun to meet my former Scripps Chair Uli Mueller and @ardemp.bskyverified.social postdoc colleague Zhaozhu Qiu, and make new friends Alex Kolodkin, Edward Twomey, and Xinzhong Dong.

Too kind!

Excited to join Bluesky today! As an ion channel biophysicist, Professor at Duke Neurobiology, and Director of Graduate Studies I will be sharing my insights. Plus the occasional post of my private life. Please help me connect to my community by sharing this post.

Follow the work of the Grandl Lab: sites.duke.edu/grandllab/