Isabela Corina Fortunato, PhD

I'm very happy to share my first article as a corresponding author published in @natmethods.nature.com !! 😍

Some groups (like us) have developed complex 3DTFM methods in the last 15 years.

BUT its usage in studies that help better understand disease or development has been almost non-existent.

Thank you, Elias! 🙏

Thank you, Nimesh 😊🙏

Single-cell migration along and against confined haptotactic gradients - Nature Physics Haptotaxis was traditionally seen as migration up protein gradients. It is now shown that cells can also oscillate or migrate down the gradient.

Paper 👉 www.nature.com/articles/s41...

How do cells navigate up gradients of adhesive proteins?
🤔

Termed "Haptotaxis", this effect is ubiquitous in cell migration, but it's mechanism was poorly understood

We show that passive friction directs cells & explains complex trajectories on gradients

👉 www.nature.com/articles/s41...

Happy to share that my PhD has finally taken the shape of a paper! ✨

Huge thanks to all authors, especially @davidbrueckner.bsky.social & @ehannezo.bsky.social for leading the modeling and @raimonsunyer.bsky.social & @xaviertrepat.bsky.social for their invaluable supervision.

🧵👇

Stoked to announce that I received a poster award! 🔥😍

Many thanks to the #25EngLife organizers for the amazing meeting!

The role of MicroRNAs in mesenchymal stem cell differentiation into vascular smooth muscle cells - Cell Division MicroRNAs (miRNAs) are small, noncoding RNA molecules that play a vital role in regulating gene expression, especially in the differentiation of mesenchymal stem cells (MSCs) into vascular smooth musc...

The role of MicroRNAs in #MesenchymalStemCell differentiation into vascular #SmoothMuscleCell

miR-1/-133/-206
miR-143/-145
miR-221/-222-5p
miR-24
miR-181
miR-503

#CellDiv 2025
celldiv.biomedcentral.com/articles/10....

Looking for #MaterialStiffness of #BasementMembrane across tissues?
Excellent literature resource here😆👇

The basement membrane as a structured surface – role in vascular health and disease

@claireleclech.bsky.social @jcellsci.bsky.social 2020
journals.biologists.com/jcs/article/...

Leveraging computational modeling to explore epithelial and endothelial cell monolayer mechanobiology Endothelial cells (ENCs) and epithelial cells (EPCs) form monolayers whose barrier function is critical for the maintenance of physiological processes and extremely sensitive to mechanical cues. Compu...

Might be an interesting review on that topic !
www.cell.com/trends/cell-...

Micro Immune Response On-chip (MIRO) models the tumour-stroma interface for immunotherapy testing - Nature Communications Modelling the tumour immune microenvironment in vitro is a valuable tool to test immunotherapy efficiency but capturing its complexity is challenging. Here authors present a fully humanised in vitro p...

1/7: New paper alert! Excited to share our co-first author paper on Micro Immune Response On-chip (MIRO) a model that recreates the tumour-stroma interface for immunotherapy testing! @oriolmb.bsky.social and I wrote this thread to break it down for you. 👇🧵
Read more: www.nature.com/articles/s41...

Cao and colleagues found that the depleted heart tissue regenerates itself in a wave, led by a front of fast-moving, supersized cells and trailed by smaller cells that multiply to produce others. The image above shows the large cells that contain multiple nuclei per cell (magenta). These cells are under more mechanical tension (aqua streaks) than trailing cells, which divide to produce cells with one nucleus each.

Regrowing a zebrafish heart. Credit to @cao-lab.bsky.social. #ZebrafishZunday 🧪

Let's look at some cool bilateral cellular flows videos
IMHO: this is a goldmine for #EpithelialMechanics
Movie from Asai et al 2024 shows beautiful counter rotating flows.

Is endothelium a type of epithelium?

I am @icfortunato.bsky.social & I would like to discuss this with a short🧵 focused on cell-cell junctions, specifically adherens junctions.

Curvature-sensing BAR proteins control junction turnover to promote collective migration of endothelial cells in angiogenesis. rdcu.be/d6a04

Force transmission is a master regulator of mechanical cell competition Cell competition is a tissue surveillance mechanism for eliminating unwanted cells and as such is indispensable in development, infection and tumorigenesis. Although different biochemical mechanisms a...

Thrilled to share our new manuscript on how force transmission can regulate mechanical cell competition!

Fun collaboration between the @bladoux.bsky.social / @rmmege.bsky.social and the Doostmohammadi group combining experiments and simulations.
Main points below 👇

www.biorxiv.org/content/10.1...

😊

🎈New preprint! We study how single cells move up, down and about fibronectin gradients. Experiments by @icfortunato.bsky.social, theory by David Bruckner. Collaboration with @raimonsunyer.bsky.social and @ehannezo.bsky.social 👇https://biorxiv.org/cgi/content/short/2024.12.02.626413v1