Jimmy Gollihar

Engineering and structures of Crimean-Congo hemorrhagic fever virus glycoprotein complexes Crimean-Congo hemorrhagic fever virus is a widespread tickborne virus that infects humans. Engineering-based structural studies of the viral glycoprotein complexes GP38-Gn and GP38-Gn-Gc provide insights to their function in the viral life cycle. GP38-Gn-Gc confers partial protection against lethal viral challenge in mice, showing promise as a vaccine antigen for further development.

I'm happy to announce that our paper is now online in Cell! This study was the result of a highly collaborative effort from many scientists. Please read it here: www.cell.com/cell/fulltex...
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Replicating RNA vaccine confers durable immunity against Crimean Congo hemorrhagic fever virus challenge in mice - npj Vaccines npj Vaccines - Replicating RNA vaccine confers durable immunity against Crimean Congo hemorrhagic fever virus challenge in mice

Another update on our #CCHF vaccine that is marching towards phase I clinical trial. Here we report on the durability of protection in a mouse model of CCHFV infection. Excellent work from our colleagues at RML/NIAID🧪 www.nature.com/articles/s41...

Directed evolution of an orthogonal transcription engine for programmable gene expression in eukaryotes Genetics; Molecular biology; Biomolecular Engineering

Our capping T7 manuscript is now published. Enjoy!

www.cell.com/iscience/ful...

Unknown disease kills 143 people in south-west DRC, local authorities say Infected people described as having flu-like symptoms including high fever and severe headaches

“Infected people had flu-like symptoms including high fever and severe headaches, Remy Saki, the deputy governor of Kwango province, and Apollinaire Yumba, the provincial minister of health, said on Monday.

A massively parallel reporter assay library to screen short synthetic promoters in mammalian cells - Nature Communications Context-dependent, responsive synthetic promoters are crucial for a wide range of applications, yet currently available options are limited. Here, authors develop a library of thousands of candidate p...

www.nature.com/articles/s41...

More comments on Boltz-1

Mmseqs2-GPU integration is super fast. Helped a ton with an enzyme-substrate pair. It’s much better quality software engineering than most academic models and easy to use. Thanks @gcorso.bsky.social, you guys did great. I put some fun logos on OpenBioML you might find fun.

Cryo-electron micrograph image (or more properly, the average of 1,236 such images) of a 6-pointed star-shaped protein complex found in the interior of slime mold cells.

Question for the #CryoEM crowd: does anyone happen to recognize this lovely ~10-15nm diameter protein complex we stumbled across while imaging slime mold protein lysate (as one does)?

Thrilled to announce Boltz-1, the first open-source and commercially available model to achieve AlphaFold3-level accuracy on biomolecular structure prediction! An exciting collaboration with Jeremy, Saro, and an amazing team at MIT and Genesis Therapeutics. A thread!

WHO study lists top endemic pathogens for which new vaccines are urgently needed A new World Health Organization (WHO) study published today in eBioMedicine names 17 pathogens that regularly cause diseases in communities as top priorities for new vaccine development. The WHO study...

www.who.int/news/item/05...

Graphical abstract of the published manuscript.

New paper from Amit Khandhar’s team at HDT Bio demonstrating that our LION/repRNA platform can be thermostabilized by lyophilization, enabling refrigerator stability for at least 1 year!

Clear implications for global access to vaccines based on our technology.

authors.elsevier.com/c/1k6n4cI2-5...

@mclellanlab.bsky.social

My graduate student Nasim Abdi just won 2nd place for her poster at the International Conference for Pandemic Preparedness in Trieste, Italy! www.pathogen-ri.eu/conference/. Great collaboration with @drjimmydale.bsky.social at Houston Methodist🤝

Hello, World!