Sebastian Roemer-Cassiano

Special shoutout to @csabaorban.bsky.social and @leonooi.bsky.social for co-leading this work! Huge thanks to @nfranzme.bsky.social , @sebroemer.bsky.social and all our collaborators for contributing their invaluable datasets! Truly an amazing joint effort! ❤️

11/11 Nicolai Franzmeier @sebroemer.bsky.social Qingyu Hu @jianxunren.bsky.social Hesheng Liu @sidchop.bsky.social @carrisacocuzza.bsky.social Justin Baker, Juan Helen Zhou @danilobzdok.bsky.social @sbe.bsky.social @avramholmes.bsky.social

Happy to share our new work by Carla Palleis in Movement Disorders showing that brain networks shape neurodegeneration patterns in PSP
=> This suggests that grey matter atrophy expands across connected brain regions, potentially following tau accumulation in PSP

doi.org/10.1002/mds....

Alpha synuclein co-pathology is associated with accelerated amyloid-driven tau accumulation in Alzheimer’s disease - Molecular Neurodegeneration Background Aggregated alpha-Synuclein (αSyn) is a hallmark pathology in Parkinson’s disease but also one of the most common co-pathologies in Alzheimer’s disease (AD). Preclinical studies suggest that...

Excited to share our new work in Molecular Neurodegeneration, showing that α-synuclein co-pathology is common in Alzheimer’s and accelerates amyloid-related tau accumulation, supporting its role as a tau co-aggregation factor.

doi.org/10.1186/s130...

Many thanks to the ADPD2025 committee for recognizing our work with @nfranzme.bsky.social on the effects of amyloid-induced hyperconnectivity on tau spreading! If you are enjoying a Gösser Radler and a Sacher Torte in Vienna, don't miss ADPD and my talk in Hall C at 10:00 on Wed 02.04.25

Nice to see Alzforum covering our most recent article in Science Transl Med and highlighting its importance for future lines of research and therapy! Special thanks David Jones and Tarick Pascoal for the great comments on our work!

alzforum.org/news/research-…

So cool to finally see this project published in Science Transl Med. The idea came from clinical observation and ripened over many discussion with the best PI @nfranzme.bsky.social one can imagine. A new mechanism linking amyloid and tau, let’s explore it further and target it therapeutically!

Happy to share our new preprint led by Johannes Gnörich and @matthiasbrendel.bsky.social, showcasing a full ATN staging approach using a single dynamic PI-2620 scan, leveraging advanced kinetic modelling techniques

www.medrxiv.org/content/10.1...

What’s new in Alzheimer’s disease imaging? We’ll find out the next three days at #HAI2025 in Puerto Rico! And thanks to Alzheimer’s Association, Biogen, BMS and the Rainwater Charitable Foundation for giving me a conference fellowship, which allowed me to attend in the first place!

Paper alert: We performed a prognostic validation of the MDS PSP criteria, showing most patients with possible/suggestive PSP show an increase in diagnostic certainty over time. Increase in diagnostic certainty could be used as an endpoint in trials
doi.org/10.1002/mds....

Amyloid-β and tau deposition in traumatic brain injury: a study of Vietnam War veterans De Bruin et al. report that traumatic brain injury does not inherently elevate the Alzheimer’s pathologies amyloid-β or tau, but is associated with their u

Very happy to share the first PhD work by Hannah de Bruin, showing that traumatic brain injury is not linked to higher fibrillar amyloid and tau per se, but to altered patterns of tau deposition preferentially in TBI vulnerable regions
doi.org/10.1093/brai...
@rikossenkoppele.bsky.social

Thought provoking Academy of the Max Planck School of Cognition with talks from sleep in worms over neurogenesis in mice to consciousness in men - thanks to all the speakers (Bringmann, Kempermann, Melloni, Amunts + many more) for sharing your insights with us
PS: what’s wrong in the MRI??

Had a great time in Cambridge thanks to the AFI foundation and my PI Nico Franzmeier! Amazing research and pub culture with the Maura Malpetti lab - can’t wait to return next year with the Thiemann Foundation

Neuronal and oligodendroglial, but not astroglial, tau translates to in vivo tau PET signals in individuals with primary tauopathies - Acta Neuropathologica Tau PET has attracted increasing interest as an imaging biomarker for 4-repeat (4R)-tauopathy progressive supranuclear palsy (PSP). However, the translation of in vitro 4R-tau binding to in vivo tau P...

Massive paper alert: We performed extensive profiling of PI-2620 for 4R tauopathies. PI-2620 tau PET signals in PSP stem from neuronal and oligodendroglial tau, not astrocytes. Signals correlate with fibrillary tau, autoradiography, and autopsy data in PSP
doi.org/10.1007/s004...