Every time you experience something new, your brain faces a decision: Should it update an existing memory or create a new one?
In our new paper in @sfnjournals.bsky.social #JNeurosci, we isolate that exact decision, moment-by-moment during learning 🧵
This was a massive effort across Arc, @NVIDIAHealth, @Stanford, & many collaborators. Congratulations and thank you to everyone who contributed to this project.
Learn more from @pdhsu and @brianhie about Evo 2’s first year: arcinstitute.org/news/evo-2-o...
Try it for yourself.
Using Evo Designer, you can paste in a DNA sequence to score variants or generate new sequences in real time.
See how it works: youtu.be/6P0L1qG_PhU
In the updated paper, the team used Evo 2 to generate synthetic DNA that produced experimentally confirmed changes in chromatin accessibility in both mouse & human cells (AUROCs 0.92–0.95).
Code, weights, and resources available here: arcinstitute.org/tools/evo
Since last February, Evo 2 has seen 200+ citations, 88K+ downloads, and 8M+ API requests. Groups at Yale, JohnsHopkins, NCState & UW have applied Evo 2 to problems from Alzheimer's risk prediction to 3D genome structure
First released one year ago, Evo 2 predicts variant effects & generates functional DNA across all domains of life, from bacteria to humans, from a single set of weights, with no fine-tuning required.
www.nature.com/articles/s41...
Evo 2, the largest fully open biological AI model to date, is now published in @nature.com
youtu.be/o_w-E--u7GQ
Evo 2, a large-scale AI model trained on over 128,000 genomes, can analyze genetic sequences across all domains of life and assist in disease mutation prediction and genome design.
Most genetic interaction studies measure gene relationships in one condition, but environment can reshape which genes depend on each other.
Today in Molecular Cell, Luke Gilbert & team deliver the first systematic, multi-condition map of genetic rewiring in human cells.
Finding one mutation that improves a protein is hard. Finding five that work together is exponentially harder.
Today in @science.org, Hsu and Konermann labs present MULTI-evolve, a lab-in-the-loop framework that does it in just one machine learning-guided round.
"Alex Pretti was a nurse to the end. His death should galvanize the rest of us." www.statnews.com/2026/01/27/a...
The final Calvin and Hobbes, which appeared in papers 30 years ago today.
This paper for example: people who are toxic on political subreddits are also toxic on subreddits that have nothing to do with politics
✨ That’s our 2025 wrapped!
Thank you to our participants, students, collaborators & community for making this year such a success.
✨ That’s a wrap on 2025!
From research milestones to community connections, we’ve accomplished so much this past year. Here’s a look back at everything we did together...
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🧵Our new preprint shows how the brain develops to transform how kids, teens & adults represent & navigate their world: shifting from local, moment-to-moment memories in childhood to integrated, global cognitive maps in adulthood 🧠
Paper: www.biorxiv.org/content/10.6...
📣 📣 Calling all #scicomm practitioners and enthusiasts in #NYC! 📣 📣
SciCommUnity NYC is hosting our first after work mixer on Tuesday, January 13th at 6pm! Come mingle with our members and spark new connections with NYC-based scicommers!
RSVP here: luma.com/xfr3trbn
Hope to see you there!🗽🪐 🧬
Alcohol GRC attendees - please be careful, as there are spam emails requesting payment. Payment is only thru the GRC website! #alcoholGRC2026 #GRC
(1/6) We have a new paper out in #eNeuro!
How does the brain’s reward processing change across social contexts? We mapped brain activity (cFos) & found that social context reshapes how reward circuits are coordinated🐭🏆
Read more: www.eneuro.org/content/12/1...
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Encouraging children & teens to manage their schedules independently has positive impacts for their memory!
Our new study reveals that age & independence combine to enhance memory development 🧵
Read here: osf.io/preprints/ps...
Do you know what snail shells & teeth have in common? 🐌🦷
They both grow in distinct layers! Snail shells add spiral layers as they age, much like how our teeth show incremental layers of enamel...
www.scientificamerican.com/article/how-... 🧪
As @sfn.org kicks off, here is some guidance to help you get the most out of it—plus a request for principal investigators to train students in “soft skills.”
By @drnancypadilla.bsky.social
#SfN25 #neuroskyence
www.thetransmitter.org/craft-and-ca...
GREAT JOB ALERT!
ProPublica is hiring another senior editor for our Local Reporting Network.
The editor will edit the work of 4-5 reporters from our partner newsrooms, collaborating on projects that spur change.
💰 Salary range: $150,000 to $195,000
➡️ Apply: propub.li/3JAIqme
A house sparrow, a small grey and brown bird begging for food on a grey carpet
An auspicious start for my travel to San Diego for #SfN25 #SfN2025 - the elusive airport sparrow! If you want to learn more about songbirds, come to my poster Saturday evening or Monday morning!
Don't Buy Starbucks! At any location, today and beyond, while workers are on ULP strike!
As of this morning, Starbucks workers across the country are officially ON STRIKE. And we're prepared for this to become the biggest and longest ULP strike in Starbucks history.
Say #NoContractNoCoffee with us: DON'T BUY STARBUCKS for the duration of our open-ended ULP strike! $SBUX
