Tzu Ching (Sunny) Su

Are you a recent neuroscience graduate student looking for a postdoctoral position, or a gap year student interested to pursue a PhD? Do you have a genuine interest in metabolic axon-glia communication? Please check out our website: www.axonglia.com We are hiring at all levels.

This is figure 5, which shows the therapeutic efficacy of a plaque-evading lithium salt.

Lithium has an essential role in the brain and is deficient early in Alzheimer’s disease, which can be recapitulated in mice and treated with a novel lithium salt that restores the physiological level, according to a paper in Nature. go.nature.com/47mxemu #medsky 🧪

Aggrecan protects against plaque accumulation and is essential for proper microglial responses to plaques Barahona et al. show that loss of aggrecan, a key structural protein in perineuronal nets, increases plaque pathology in mice. Their findings indicate that the lack of aggrecan impairs microglial enga...

Cell-type-directed network-correcting combination therapy for Alzheimer’s disease A multi-cell-type drug discovery strategy targeting dysregulated gene networks in neurons and glia identified letrozole and irinotecan as a combination therapy that significantly improved memory and r...

The Sirota & Huang labs identified a novel letrozole–irinotecan combination therapy that improves memory and reduces pathology in Alzheimer's disease models—showcasing a transformative drug discovery approach rooted in human transcriptomics and real-world clinical data www.cell.com/cell/fulltex...