Emma McKay

The Irish Academy of Fine Arts, at the GPO Why the GPO?  The GPO offers a rare and remarkable opportunity. Many of the great academies of Europe, such as the Royal Academy in London, the Repin Academy in St. Petersburg, the Ecole de beaux...

This cause is close to my heart - please sign: my.uplift.ie/petitions/th... @uplift.ie

Delighted to announce I passed my PhD viva yesterday! Many thanks to my examiners @kesslerbenedikt001.bsky.social and @gunnarns.bsky.social for the fantastic discussion and feedback. Thanks as well to my incredible supervisors Ben Collins and @colllab.bsky.social, and everyone in the labs!

Thank you for everything Rebecca! 🍾 👩‍🔬

So proud of the new Dr @emmamckay.bsky.social for smashing her PhD viva! Huge thank you to her examiners @kesslerbenedikt001.bsky.social @gunnarns.bsky.social for great discussions on NLRP3 inflammasomes and proteomics - first student co-supervised with Prof Ben Collins 😊

Great couple of days in Manchester for the excellent @britsocimm.bsky.social Innate Immunity and inflammation meeting #BSIInflammation25

Brilliant couple of days attending the Irish Society for Immunology annual meeting in Galway. Great science in a beautiful place!

Had a brilliant couple of days in Galway with the lab at the Irish Society for Immunology meeting - great science and great craic!!!

Clustering of NLRP3 induced by membrane or protein scaffolds promotes inflammasome assembly - Nature Communications NLRP3 inflammasome activation is critical for the induction of protective immunity, but molecular insights are still lacking. Here, the authors express NLRP3 variants targeted to different cellular lo...

NLRP3 inflammasomes can assemble on most organelles. A beautiful study by Hafner et al demonstrate the flexibility of organelles that can support inflammasome activation. Kudos to the authors on an intriguing study.
www.nature.com/articles/s41...
@ivahb.bsky.social @elvirab.bsky.social

Course at EMBL-EBI Proteomics bioinformatics 14 - 18 July 2025 Hinxton, United Kingdom

If you’re looking to gain hands-on training in the basics of mass spectrometry and proteomics bioinformatics, then this course is for you! Make sure you’ve submitted your application by 6 April: www.ebi.ac.uk/training/eve...

Some financial assistance is available - see the course website.

🧪🧶🧬🖥️

Understanding how high plasma soluble urokinase plasminogen activator receptor (suPAR) predicts poor outcome in patients with ARDS. at Queen’s University Belfast on FindAPhD.com PhD Project - Understanding how high plasma soluble urokinase plasminogen activator receptor (suPAR) predicts poor outcome in patients with ARDS. at Queen’s University Belfast, listed on FindAPhD.com

We are recruiting a student for a really exciting PhD project on understanding how high plasma suPAR predicts poor outcome in patients with ARDS @wwiem-qub.bsky.social #ARDS #criticialcare
- any questions please get in touch! (open to UK and RoI) www.findaphd.com/phds/project...

TBK1 and IKKε prevent premature cell death by limiting the activity of both RIPK1 and NLRP3 death pathways TBK1 and IKKe prevent premature cell death by limiting the activity of multiple death pathways in myeloid cells.

The loss of TBK1, or both TBK1 and the related kinase IKKε, results in uncontrolled cell death–driven inflammation. We show that TBK1/IKKε prevent premature cell death by limiting the activity of multiple death pathways in myeloid cells. www.science.org/doi/10.1126/...

If pubmed is inaccessible at the moment, try @europepmc.org

Plasticity of cell death pathways ensures GSDMD activation during Yersinia pseudotuberculosis infection Injection of YopJ by Yersinia pseudotuberculosis triggers RIPK1-dependent caspase-8 and GSDMD activation in murine macrophages; however, how macrophages defend against Yersinia when caspase-8 or YopJ ...

Thrilled to start 2025 with our latest findings! Yersinia invades macrophage cytosol to activate caspase-11 when caspase-8 or YopJ are inactive. www.cell.com/cell-reports...

Discovery of a Potent and Selective Inhibitor of Human NLRP3 with a Novel Binding Modality and Mechanism of Action https://www.biorxiv.org/content/10.1101/2024.12.21.629867v1

Pyroptotic cell corpses are crowned with F-actin-rich filopodia that engage CLEC9A signaling in incoming dendritic cells Nature Immunology - Pyroptotic cell death results in inflammation. Here the authors find that F-actin-rich structures formed during macrophage pyroptosis persist after cell death to activate...

Have you ever wondered whether pyroptotic corpses have functions beyond the grave? We made the surprising discovery that pyroptotic corpses are flagged by #filopodia to alert #DendriticCells they need autopsy. A short Bluetorial (1/13)👇with movies!
Link: rdcu.be/d2mjm

Hi #TeamMassSpec! #FeMS+ has joined BlueSky! Please share and get the word out so we can build up a base here.

@inflammasomelab.bsky.social was the lucky 100th added to this starter pack! Definitely one to follow for all the incredible #inflammasome #inflammation work they do!
go.bsky.app/QqJ9AgB

The unofficial FeMS starter pack (until they join us on Bluesky :) anyway. If you're a woman working with a mass spectrometer please ask to be added! All women are welcome!

go.bsky.app/PUwu7fr

First post on Bluesky, let’s share some websites offering many free illustrations for scientific figures 🖼️ 🧪 🌍 :

scidraw.io

bioart.niaid.nih.gov

www.phylopic.org

More well known but very nice though: www.freepik.com

🎨 In case anyone need…

The NIH BioArt Source is an awesome library of *free* professionally drawn illustrations for scientific presentations or figures. Downloadable in HD. Thank you NIH for this invaluable tool 🙏!

Check it out 👇
bioart.niaid.nih.gov

My proteomics resources on Bluesky:

Proteomics Starter Pack (full): go.bsky.app/HH7kqEh PSP converted into a List so more researchers can be added: (bsky.app/profile/did:...)

Early Career Researchers in Proteomics Pack: go.bsky.app/Dp8PHX1

Single Cell Proteomics Pack: go.bsky.app/KYdPDb8

The wave is rising 🌊🦋
In just a few days, we have surpassed the halfway mark of people in this #innateimmunity and #inflammation starter pack!
Contact me to be added or tag someone you think should be on here.
#immunosky #academicchatter

go.bsky.app/QqJ9AgB

go.bsky.app/221DCXf

Scaffolding of NLRP3 on osmotically swollen vesicles but not intermediate filaments promotes inflammasome assembly https://www.biorxiv.org/content/10.1101/2024.11.18.624139v1 Inflammasomes are nucleated by receptors that become activated upon cellular stresses including ioni

Scaffolding of NLRP3 on osmotically swollen vesicles but not intermediate filaments promotes inflammasome assembly https://www.biorxiv.org/content/10.1101/2024.11.18.624139v1