Tim Sheahan

Hiked up to the “Big C” at @ucberkeleyofficial.bsky.social via Cyclotron road. My particles were accelerated once I got to the top #physics #crystalography #biology

Loss of nsp14-exonuclease activity impairs the replication, proofreading, fitness and pathogenesis of SARS-CoV-2 Coronaviruses (CoVs) replicate their RNA genomes with increased fidelity than other RNA viruses, a mechanism mediated by the proofreading and recombination activities of the exoribonuclease domain of ...

Our new preprint on #SARSCoV2 nsp14 #exonuclease function in replication fidelity and fitness. ExoN- viruses are attenuated in vitro and in vivo but w/o #interferon signaling replication is largely restored! Suggests nsp14 plays a role in innate antagonism in vivo www.biorxiv.org/content/10.6...

Human coronavirus 229E antibodies and Spike structure function paper is finally out for real. Led by @wrapplab.bsky.social (wrappers delight) and @mlicc1701.bsky.social (MFL) #lovevirology #229E #antibodies www.nature.com/articles/s42...

Did you mean to write “Jean Lim”?

Mouse-adapted SARS-CoV-2 Omicron BA.5 infection induces post-acute lung fibrosis in BALB/c mice | Journal of Virology To best combat the evolving landscape of SARS-CoV-2 variants of interest and variants of concern, the development of effective small animal models is of critical importance. Herein, we describe the de...

New #coronavirus #postacute lung pathogenesis paper from my friend Dr. John Powers is up at @asm.org JVI. journals.asm.org/doi/10.1128/... Confusing as to why this link shows a rotund blue bird. #PASC #SARSCoV2 #Omicron #LoveVirology #JVI #ASM #virology

Grant writing w ballet rehearsal on the side. #coronavirus #exonuclease is cool shit. Guides replication fidelity and we think masterminds control of the host response. Oh my. If only my 12 pages were done? #grantwriting #acadreamia #nih #coronavirus

MERBelous? I’m SARSy for the bad jokes.

ACE2 from Pipistrellus abramus bats is a receptor for HKU5 coronaviruses - Nature Communications This work shows that receptor use in merbecovirus is clade-specific by clustering them into clades based on the receptor-binding domain (RBD) of their spike proteins. While MERS-CoV and its close rela...

New paper about ACE2 using Merbecovirus. Hot stuff. So hot but you can't Letko. @fviromics.bsky.social and Nick Catanzaro. www.nature.com/articles/s41... #ACE2 #emergingviruses #bats #batman #MERS #HKU5

@mattfrieman.bsky.social taped this to my lab notebook almost 20 years ago. It’s not untrue 🤣Vestiges of simpler times. #lovevirology #virology #lablife #sars #laboratory #science #biology #academia

So nice to be teamed up with @wrapplab.bsky.social on this mAb project! It's been a delight. Some may say a Wrapper's Delight? #antibodies #virology #lovevirology #229E #coronavirus #therapeutics #vaccination #emergingviruses

Having a hard time processing this. HHMI is pausing all competitions. Very demoralizing for early career scientists like me @hhmi.org

NIH grant terminations under Trump have totaled at least $1.8 billion, analysis finds Researchers calculated that $1.8 billion in National Institutes of Health grants were terminated in just over one month

How much federal research funding has been axed so far in the new administration? An early estimate is $1.8B, but that's likely an underestimate, @aniloza.bsky.social reports. www.statnews.com/2025/05/08/t...

Exclusive: NIH to suspend funds for research abroad as it overhauls policy Move by US biomedical agency threatens thousands of projects on infectious diseases, cancer and more.

www.nature.com/articles/d41...

One of the many things I lack…

How does one determine EC50 w a curve like this? #antivirals #coronavirus #cell www.sciencedirect.com/science/arti...

Thank you @holdenthorp.bsky.social for being a voice which eventually we can hopefully build into a chorus. It's hard to not fall into a daily bleakness black hole (DBBH).

NIH has rescinded its scientific integrity policy. Hard to see this as anything other than clearing the way for shoddy research on things like vaccines. Regardless of the rationale, it's bad news for public health.

grants.nih.gov/grants/guide...

H.H.S. Scraps Studies of Vaccines and Treatments for Future Pandemics (Gift Article) Federal officials cited the end of the Covid-19 pandemic in halting the research. But much of the work was focused on preventing outbreaks of other pathogens.

"Angry, disappointed, frustrated"--Scientists were making progress on vaccines and antivirals for the next pandemic--until this week, when the Trump administration abruptly told them to stop. Here's my story with @apoorvanyt.bsky.social Gift link: nyti.ms/43Xz77q

The damage being done to the biomedical community will probably not be appreciated for years

Broad-spectrum antiviral GS-5734 inhibits both epidemic and zoonotic coronaviruses Broad-spectrum antiviral GS-5734 inhibits both epidemic and zoonotic coronaviruses in vitro and in vivo.

FYI @veeslerlab.bsky.social We showed remdesivir worked against HKU5 in the paper linked below. Nice you have confirmed this! www.science.org/doi/10.1126/...

Federal Register hold makes ‘end run’ around court pause on NIH funding freeze NIH-related updates to the Federal Register, which are required for the scheduling of study sections and advisory councils, are on hold indefinitely, according to an email reviewed by <i>The Transmitt...

I just covered this for @thetransmitter.bsky.social — will keep following! www.thetransmitter.org/funding/fede...

Dysregulation of lung epithelial cell homeostasis and immunity contributes to Middle East respiratory syndrome coronavirus disease severity | mSphere Emerging coronaviruses like SARS-CoV, SARS-CoV-2, and MERS-CoV cause a range of disease outcomes in humans from an asymptomatic, moderate, and severe respiratory disease that can progress to death but...

Saved from death in the paper grave yard! Started in 2016. MERS-CoV infects epithelial cells, they die, pathology is wicked bad. Adaptive immune cells both control replication and drive pathogenesis. #coronavirus #MERSCoV #pathogenesis #LoveVirology #viruses #virus journals.asm.org/eprint/ZZEIT...

Trump hits NIH with ‘devastating’ freezes on meetings, travel, communications, and hiring Researchers facing

Trump hits NIH with ‘devastating’ freezes on meetings, travel, communications, and hiring www.science.org/content/arti...

“Rob” is now transcribed as “Ellen”?

When was the last MHV pandemic?

There is a lot of nuance to this policy and the local IBCs now seem to have a lot more decision making power. This says any manipulation or modification of the virus requires IBC risk assessment. Stringency of IBC review probably varies depending on institution. This is a problem.

RFK Jr.’s Lawyer Has Asked the FDA to Revoke Polio Vaccine Approval Aaron Siri, who specializes in vaccine lawsuits, has been at Robert F. Kennedy Jr.’s side reviewing candidates for top jobs at the Department of Health and Human Services.

Just when you though Apple’s #Siri was the most annoying and egregiously offensive Siri…https://www.nytimes.com/2024/12/13/health/aaron-siri-rfk-jr-vaccines.html?smid=nytcore-ios-share&referringSource=articleShare&sgrp=c-cb

Can one get both jobs? $$$$ hahahahaha

Excited for my first bluesky post announcing TWO openings for tenure track positions in virology! I am chair of the search committee and with a new department head Mike Gale we are in an exciting building phase.

Please share with anyone who might be interested: hr.myu.umn.edu/jobs/ext/365...