Patricia Yuste-Checa

Structural & functional analysis revealed that the extracellular #chaperone #clusterin functions through two tails in preventing protein aggregation.

❕Paper: www.nature.com/articles/s41...
❕Press Release: www.biochem.mpg.de/structure-of...

#Alzheimers @natsmb.nature.com @pyustecheca.bsky.social

Thank you @leokiss.bsky.social !!

Structural analyses define the molecular basis of clusterin chaperone function Nature Structural & Molecular Biology - The authors reveal a three-domain architecture of glycoprotein clusterin and show that the hydrophobic tails are crucial for clusterin’s functions...

Curious about the structure and functional analysis of one of the most abundant and enigmatic extracellular #chaperones and one of the highest genetic risk factor for developing late onset #Alzheimer’s disease? Check out our paper on Clusterin/ApoJ!
#proteostasis #apolipoprotein
rdcu.be/ezRLv

Structural analyses define the molecular basis of clusterin chaperone function Nature Structural & Molecular Biology, Published online: 08 August 2025; doi:10.1038/s41594-025-01631-4The authors reveal a three-domain architecture of glycoprotein clusterin and show that the hydrophobic tails are crucial for clusterin’s functions as an extracellular molecular chaperone and apolipoprotein, as well as for receptor binding and cellular uptake.

New online: Structural analyses define the molecular basis of clusterin chaperone function

The ribosome as a platform to coordinate mRNA decay Abstract. Messenger RNA (mRNA) homeostasis is a critical aspect of cellular function, involving the dynamic interplay between transcription and decay proce

Exicted to share our latest review in @narjournal.bsky.social on how the ribosome coordinates mRNA decay with a focus on structural advances in the field.

#ribosome #mRNAdecay #translation