www.oeaw.ac.at/gmi/detail/n...
23.02.2026 21:22
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Congratulations, Alibek! Such a cool Frankenstein story 🎉
Really happy to see this one out: www.sciencedirect.com/science/arti... Alibek's drive & great coll w/ friends @gekaragoz.bsky.social & E. Hallacli resulted in a cool story that starts with our beloved #Marchantia and ends with iPSC-derived neurons 🤩🤪 A short 🧵
PhD defended 🎓
#PhDone and discussed in detail
Big shoutout to all colleagues who supported me throughout the journey, and especially to Elif @gekaragoz.bsky.social. Proud and excited to continue our scientific adventures!
If you’re enjoying some calm while others are on holiday, here’s a #NEW #preprint to dive into — led by the brilliant @vbcscitraining.bsky.social student A. Abdrakhmanov:
👇 A quick thread + link:
www.biorxiv.org/content/10.1...
📑 New study! Why would cells invest in a protein that degrades within minutes? TRIM52 is one of the most unstable proteins in the human proteome. Research by @versteegga.bsky.social in Nature Communications reveals its advantageous role ➡️ tinyurl.com/yw6wtzkc
@univie.ac.at
@meduniwien.ac.at
Huge thank you to our collaborators, Ameres @ameressl.bsky.social and Versteeg labs, for their essential input, insights, and support!
6/ 📜 Check out the full study for details!
www.biorxiv.org/content/10.1...
@gekaragoz.bsky.social @maxperutzlabs.bsky.social @vbcscitraining.bsky.social
#RNA #UPR #ERstress #IGF2BP3 #RBP
5/ 🏥 Why does this matter? The UPR is implicated in development and cancer - contexts where IGF2BP3 is highly expressed. This dual-layered regulatory mechanism may allow cells to shift between opposing IGF2BP3 functions, enabling cell state-specific fate decisions.
4/ 🔬 Mechanistically, we observed increased association of IGF2BP3 with the mRNA decapping complex during ER stress, which can result in enhanced degradation of IGF2BP3 targets
3/📉 By tracking changes in total and newly transcribed mRNAs, we show that IGF2BP3 facilitates UPR via two distinct mechanisms:
• It reduces protein folding load by destabilizing most of its target mRNAs
• It upregulates UPR effectors stabilizing mRNAs encoding select transcriptional regulators
2/🔬 IGF2BP3 is an RNA-binding protein known for regulating mRNA stability, particularly in development & cancer. Surprisingly, under ER stress, IGF2BP3 binds key UPR effector transcripts including XBP1, HSPA5, and DDIT3 (CHOP) —major regulators of ER stress adaptation & apoptosis
1/ Thrilled to share the core of my PhD project—just posted on BioRxiv!🚨 We uncover a novel role for IGF2BP3 in regulating the cellular response to the endoplasmic reticulum (ER) stress – the unfolded protein response (UPR). Thread 🧵 (1/6) ⬇️
www.biorxiv.org/content/10.1...