Maciej Florczyk

#Immunology out now @science.org

After initial priming in the lymph nodes, mouse CD8 T cells undergo a second phase of stable interactions with dendritic cells that can preferentially stimulate those with a high-affinity for antigen.

buff.ly/49bKcTG

By Jobin, Seetharama, Rüttger et al.

📢Happy to share our @natrevimmunol.bsky.social article; Result of #collaboration with @deadoc80.bsky.social @labliston.bsky.social & K Smith!
📑Read here: rdcu.be/ehm67
🔥Take🏠msg: Time to move away from narrow concept of #exhausted T cells to other #hypofunctional #states! 1/6🧵
@oncodaily.bsky.social

Programs, origins and immunomodulatory functions of myeloid cells in glioma - Nature A study of myeloid cells in gliomas, a type of brain tumour, used a factor-based computational framework to reveal four immunomodulatory gene-expression programs that are expressed across myeloid cell...

Programs, origins and immunomodulatory functions of myeloid cells in glioma | Nature

www.nature.com/articles/s41...

Ok so… There’s a nice little park on a corner, and a path running directly to one edge of the park. That’s the first image, but there’s 12 other images here. In the second image, there is now a desire path running diagonally across the park. Next image, the path has been blocked by a park bench that the council has put in as a deterrent. Unfazed, in image 4 the path now deftly avoids the park bench. In images 5 and 6 the process is repeated, this time with a strategically placed bin which the desire path also avoids. Presumably in a fit of rage, the council plants an entire hedge to stop people creating new desire paths but eventually this too is defeated and a new path find a way. Finally, the council admits defeat and turns the desire path into a proper paved pathway. After a little while, a new desire path curving off this new paved pathway begins to emerge…

A little comic about desire paths.

Registration for the Antwerp T-cell Repertoire (ATCR) meeting has opened!

It aims to bring together experts, researchers and industry on the study of T-cells through novel high throughput sequencing technologies.

Check out the exciting speaker list!
www.uantwerpen.be/en/conferenc...

Distinct myeloid-derived suppressor cell populations in human glioblastoma The role of glioma-associated myeloid cells in tumor growth and immune evasion remains poorly understood. We performed single-cell RNA sequencing of immune and tumor cells from 33 gliomas, identifying...

Distinct myeloid-derived suppressor cell populations in human glioblastoma
doi.org/10.1126/scie...

DEGRADATOR: A Gaming Expedition Into Targeted Protein Degradation Therapies In an era of rapid scientific advancement, the need for engaging educational tools is critical. DEGRADATOR, a 2D computer game, bridges this gap by immersing players in the ubiquitin-proteasome system...

Our first educational project, DEGRADATOR, is now in the Journal of Chemical Education @acspublications.bsky.social
Tested with 97 high school students, it enhances understanding of protein degradation. A step towards making molecular biology more accessible.
Read more: pubs.acs.org/doi/10.1021/...

lncRNA NORAD modulates STAT3/STAT1 balance and innate immune responses in human cells via interaction with STAT3 - Nature Communications Long non-coding RNA (lncRNA) has diverse functions. Here the authors show that a lncRNA, NORAD, interacts with an immune transcription factor, STAT3, to facilitate STAT3 nuclear import and thereby mod...

lncRNA NORAD modulates STAT3/STAT1 balance and innate immune responses in human cells via interaction with STAT3
www.nature.com/articles/s41...
@naturecomms.bsky.social
@aargoetti.bsky.social

Infiltrating plasma cells maintain glioblastoma stem cells through IgG-Tumor binding Gao et al. show that the plasma cells (PCs) can be recruited to glioblastoma stem cell (GSC) niches via the CCL2-CCR2 chemokine program and promote glioblastoma growth by regulating GSCs through the IgG-FcγRIIA-AKT-mTOR axis. Blocking PC-mediated stimulation of GSCs represents a promising therapeutic strategy for cancer immunotherapy.

Infiltrating plasma cells maintain glioblastoma stem cells through IgG-Tumor binding | Cancer cell #paper

www.cell.com/cancer-cell/...

ChromatinHD connects single-cell DNA accessibility and conformation to gene expression through scale-adaptive machine learning - Nature Communications Functional chromatin changes occur at different scales. Here, the authors introduce ChromatinHD, a method that characterises differential and predictive chromatin accessibility changes in a scale-adap...

Superb work by Wouter @Zouters & @OlgaPushkarev developing ChromatinHD, two scale-adaptive #machinelearning models & interpretation tools that use #scRNAseq + #scATACseq data to better understand how chromatin accessibility relates to gene expression doi.org/10.1038/s414...

Happy 2025 everyone 🎆 !

Monocyte-derived macrophages act as reinforcements when microglia fall short in Alzheimer’s disease - Nature Neuroscience This article discusses a puzzling issue in brain pathology: why brain-resident microglia are insufficient for protection, and why myeloid cells are needed from the periphery. Several strategies are pr...

Monocyte-derived macrophages act as reinforcements when microglia fall short in Alzheimer’s disease | Nature Neuroscience #paper

www.nature.com/articles/s41...

👉 AI meets TCR - Part 1 of computational prediction of antigen specificity doi.org/10.1016/j.ce...

Happy new year to all

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