Ghanendra Singh

Norepinephrine signals through astrocytes to modulate synapses Locus ceruleus (LC)–derived norepinephrine (NE) drives network and behavioral adaptations to environmental saliencies by reconfiguring circuit functional connectivity, but the underlying synapse-level...

Thought this would be a nice way to enter the bsky community👇Delighted for Katie (now in Chris Dulla's lab at Tufts). Thank you to our collaborators, to the reviewers and to Cagla Eroglu for the highlight!
www.science.org/doi/10.1126/...

Oligodendrocyte mechanotransduction channel TMEM63A regulates myelin sheath geometry Dereddi, Djannatian, and colleagues show that oligodendrocytes use mechanical cues to measure axon size. The stretch-activated channel TMEM63A converts membrane tension into calcium signals, which cal...

We identified how mechanical forces shape myelin development. The TMEM63A channel in oligodendrocytes converts physical cues into molecular signals that control myelin growth.

Oligodendrocyte mechanotransduction channel TMEM63A regulates myelin sheath geometry: Neuron www.cell.com/neuron/fullt...

Motivated reasoning with confirmation bias: Sometimes “We don’t reason to discover the truth, we reason to justify what we already believe.”

Astrocytes enable amygdala neural representations supporting memory - Nature Astrocytes in the basolateral amygdala dynamically track fear state and support fear memory retrieval and extinction.

Really nice work from the Holmes lab looking at amygdala astrocytes in fear memory and extinction!

www.nature.com/articles/s41...

🎉 Great news! Our paper is now published in @naturecomm
We identify a specific astrocyte ensemble that mediates THC-induced cognitive impairments during adolescence
Huge thanks to our collaborators @marsicanolab @khakhlab @grandeslab
🔗 rdcu.be/eY0Or
@jsromero.bsky.social @crismonteagudo.bsky.social

Scientific knowledge flourishes as a non zero-sum nature, nurtured by intellectual freedom and shared inquiry. However, this beauty is frequently undermined by systems that operate on zero-sum logic.

Elegance of a model lies in the simplicity of predicting a phenomena emerged based on intuitive believe 🤔, and understanding of the nature of reality captured by abstract imagination 💭 that are observed experimentally 👀, realised or discovered at a later stage.

Human 🩸🧠⏹️ #BBB on a chip 🤩

Microglia and Astrocytes in ASD.

Wanna compare dynamics across neural data, RNNs, or dynamical systems? We got a fast and furious method🏎️
The 1st preprint of my PhD 🥳 fast dynamical similarity analysis (fastDSA):
📜: arxiv.org/abs/2511.22828
💻: github.com/CMC-lab/fast...
I’ll be @cosynemeeting.bsky.social - happy to chat 😉

Distinct endocannabinoids specifically signal to astrocytes or neurons in the adult mouse hippocampus - Nature Neuroscience Distinct endocannabinoids signal to either astrocytes or neurons, evoking contrasting regulation of synaptic function. This works reveals the high degree of complexity of neuronal and astrocytic signa...

Distinct endocannabinoids specifically signal to astrocytes or neurons in the adult mouse hippocampus
www.nature.com/articles/s41...

Flyer for January 15 , 2026 seminar of the Spring 2026 Seminar Series

📢Join our first seminar in 2026! Anna Orr, PhD, Associate Professor of Neuroscience at Weill Cornell, will give a talk on “Astrocytes in Neurocognitive Function and Dementia Pathogenesis” on Thursday, January 15.

European Conference on Mathematical & Theoretical Biology 2026 ECMTB is coming to Graz, Austria in July 2026. Registration and Call for Contributions are open!

ECMTB ecmtb2026.org by SMB @smbmathbiology.bsky.social and ESMTB @esmtbio.bsky.social 🤩

Activities - Site officiel du Centre de recherches mathématiques (CRM)

International Conference on Mathematical Neuroscience @ McGill University, Montreal, Canada

2 – 5 Jun 2026

www.crmath.ca/en/activitie...

ATgliaNet Symposium 2026, March 20th, 2026 | MedUni Wien Following last year’s successful inaugural symposium at ISTA, we are proud to announce the ATgliaNet Symposium 2026, a one-day scientific meeting, with keynote speaker Prof. Leda Dimou (Medical Faculty, University of Ulm).

ATgliaNet Symposium 2026
March 20th, 2026 | Vienna

Keynote speaker Prof. Leda Dimou (University of Ulm)

Registration & abstract submission until Feb 13:
https://loom.ly/33SkUKk

Find more glia related meetings here: https://loom.ly/dwKZ1r8

Astrocytes tuning plasticity during critical periods !!

🌟 Only 6 months until #FENS2026!

Soon, the #neuroscience community will come together to exchange ideas and explore the latest breakthroughs in neuroscience. 🧠

📍 Barcelona, Spain
🗓️ 6–10 July 2026

👉 Learn more and join us in #Barcelona: fensforum.org

#FENS #FENSForum #NeuroscienceConference

Astrocytes control oxytocin-based maternal behavior via connexin 30 https://www.biorxiv.org/content/10.64898/2026.01.09.698569v1

Emergent Traveling Waves in Neural Circuits Artificial neural networks achieve striking performance but do not capture a prominent neural property. Cortical activity is organized by structured spatiotemporal dynamics, traveling waves (TW), whic...

New results! Computational models often rely on hand-crafted connectivity and imposed dynamics to produce traveling waves (TWs). We show how TWs can naturally emerge under biologically plausible conditions.
Emergent Traveling Waves in Neural Circuits
doi.org/10.64898/202...
#neuroscience

Cortical Field Model of Complex Spiral Traveling Waves Complex spiral traveling waves observed experimentally occurs across the cortex. The underlying mechanisms responsible for generating such mesoscopic activity are not well understood. Understanding ho...

Many cortical traveling waves spiral. Here's how and why.
Cortical Field Model of Complex Spiral Traveling Waves
doi.org/10.64898/202...
#neuroscience

Wow !! Another RNN based #TravelingWave #TW mechanistic model for cortical computation.
In future: 🌊 Prop > 🔙 Prop 🤩.

Astrocytic Encoding of Threat in the Basolateral Amygdala The basolateral amygdala (BLA) has long been implicated in threat detection and the generation of anxiety states. While previous experiments have demonstrated the important role of BLA principal neuro...

Delighted to share our first preprint of the year!

A project that we're all really proud of in the lab led by @ossamaghenissa.bsky.social with @mathiasgua.bsky.social in which we set out to test the role of basolateral amygdala astrocytes in anxiety behaviour.
www.biorxiv.org/content/10.6...

RMAAT: Astrocyte-Inspired Memory Compression and Replay for Efficient Long-Context Transformers
https://arxiv.org/abs/2601.00426

Beautiful 🤩 !! Function as CIM.

Complex #spiral #traveling-waves across the cortex.

Modeling endfeet aging of BBB in PFC might give us interesting insights.

MERCs in astrocytic brain aging.

Mitochondrial transfer from satellite glial cells (SGC) to neurons protects against peripheral neuropathy; SGCs are capable of transferring mitochondria to dorsal root ganglia sensory neurons in vitro, ex vivo & in vivo (via tunnelling nanotubes)
www.nature.com/articles/s41...

Happy new year everyone 🍾 To start the year we have a new webinar coming soon! Prof. Bo Peng from the Institute for Translational Brain Research in China will be our next speaker on January 13th. Check all the information in the flyer and add it to your calendar! 🧬🧠

Possibly a significant role in the Long Term WM based dynamics.