Genes with low-to-intermediate pleiotropy (1−Tau) drove most transcriptomic changes, specially contributing to the highest levels of parallelism. In contrast, early adaptation involved transient changes in more pleiotropic genes.
Most transcriptomic trajectories showed a rapid shift followed by a plateau—mirroring fitness changes and supporting the two phases of polygenic adaptation: directional and stabilizing.
A fast, concordant transcriptomic response revealed thousands of differentially expressed genes across generations.
Fecundity -a fitness component- increased rapidly over 7 generations, then plateaued suggesting the transition toward an equilibrium.
Proud to share our new preprint with Neda! @nedabarghi.bsky.social
Using experimental evolution and time-series phenotyping, we reveal the phases of polygenic adaptation driving rapid evolution in large Drosophila populations adapting to a new environment. 👉 www.biorxiv.org/content/10.1...
