Noemi Salmeri, MD

Safeguarding women and girls in the age of AI As artificial intelligence (AI) technologies become increasingly embedded in global health research and practice, they offer new opportunities to address gaps in women's health, including maternal health and gender equity. Additionally, as shown by Peige Song and colleagues in this issue, AI could help identify and prioritise research directions that address the needs of marginalised groups. Yet these technologies may also be misused to amplify harm and perpetuate inequities. The recent Grok AI scandal, involving the non-consensual creation and dissemination of explicit sexual images of women and girls through generative AI, is a clear warning of the misuse of AI.

As AI technology becomes more embedded in everyday life, they offer opportunities to address gaps in women’s health, but also pose significant harm when misused.

A @lancetgh.bsky.social Editorial discusses how to safeguard women and girls in the age of AI: spkl.io/63328AxHOA

On this #InternationalWomensDay, we recognize and honor the ob-gyns committed to ensuring that every woman receives quality and respectful care.

Together, our ACOG community is taking action to change the culture of medicine, helping to improve access to safe and quality care #ForAllWomenAndGirls.

Boost your ART ultrasound skills! 🌟
Hands-on workshop on ultrasound in gynaecology & fertility care, combining practical training & latest #ESHRE guidance.
🔸 Ovarian & adnexal pathology
🔸 COH monitoring
🔸 Interventional US
🔸 2D/3D imaging, VR training
🗓️ Sofia | 8-9 May
www.eshre.eu/Education/Ca...

Please use appropriate language in science.

@bmj.com 👏🏻

Full text ➡️ www.bmj.com/content/bmj/...

Vaccines are critical to protecting pregnant women and their infants. ACOG’s newly updated guidance urges ob-gyns to review patients’ immunization status, recommend needed vaccines, and address barriers such as misinformation. Read the full press release for more: https://bit.ly/4ro56GZ

Many thanks to all participants, experts, authors and to @gliperis.bsky.social and his team for leading this great first Bluesky edition of the #ESHREjc 🦋
See you next time! 🙌

Until next time! 👋🏻

@omarammar.bsky.social @mr-att.bsky.social @noemisalmeri.bsky.social @juanjo-fraire.bsky.social @dkalaitzopoulos.bsky.social @ribeirosara.bsky.social

🔥 Thank you everyone for attending the #ESHREjc and the first one hosted on Bluesky

Many thanks to our experts for the insightful discussion on the multifaceted role of the oocyte cortex @rvassena.bsky.social @paolavigano.bsky.social

And the # ESHREjc team 💫

Until next time! 👋🏻

Thank you for joining this #ESHREjc session! 🫶🏼
@eshre.bsky.social

A complex paper, a challenging discussion, and a great opportunity to learn in a simple (and fun) way 💡🧠

You can find the summary slides here 👇🏼👇🏼

Here the summary of our discussion for Q3 on biomechanic parameters of oocyte developmental competence #ESHREjc
@eshre.bsky.social

Almost over for this session of the #ESHREjc ⏰

Summary for #Q2 👇🏼
@eshre.bsky.social

Here’s the summary for Q1 on structural components of the oocyte cortex and GV to MII remodeling #ESHREJC @eshre.bsky.social

In other words: stiffer ovaries > more pressure on the follicle > more pressure on the oocyte > molecular response at the oocyte cortex level? #ESHREjc

a woman says i 'm eccentric not crazy on a netflix screen ALT: a woman says i 'm eccentric not crazy on a netflix screen

And actually, I wonder, we know that GV is eccentrically positioned in the oocyte. Do we know whether its position relative to the follicular wall is conserved? #ESHREjc

Reliability 🗝️ #ESHREjc

We have to assume that trancriptomic profile is able to quantify/reflect mechanical forces. #ESHREjc

Low mechanical resistance 👉top quality embryos #ESHREjc

Cell fragmentation in mouse preimplantation embryos induced by ectopic activation of the polar body extrusion pathway - PubMed Cell fragmentation is commonly observed in human preimplantation embryos and is associated with poor prognosis during assisted reproductive technology (ART) procedures. However, the mechanisms leading to cell fragmentation remain largely unknown. Here, light sheet microscopy imaging of mouse embryos …

Data so far suggest embryo fragmentation can arise de novo during early cleavages: mitotic chromosome segregation problems keep DNA near the cortex long enough to trigger ectopic actomyosin contractions, essentially a misfired “polar body–like” response. #ESHREjc

pubmed.ncbi.nlm.nih.gov/37427462/

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Q4:Given that the cortex is a part of the interface between the oocyte and cumulus cells, how might abnormalities in the follicular environment alter cortical signaling or architecture, and how could these changes be detected through non-invasive follicular fluid or cumulus cell biomarkers?
#ESHREjc

Techniques like micropipette aspiration or emerging optical microscopy approaches are promising, but translating them to IVF will require meeting the ‘holy grail’ of:

✅ Efficacy
✅ Safety
✅ Cost
✅ Speed of testing

#ESHREjc

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Q3. Coticchio et al suggest cortical properties (stiffness, viscoelasticity) could be biomarkers of oocyte developmental competence. Which technologies 🧫🔬🤖could realistically be applied in an IVF lab 👩🏻‍🔬 to measure cortex mechanics and what are the major barriers to clinical 🧑🏻‍⚕️ translation? #ESHREjc

Human oocyte developmental potential is predicted by mechanical properties within hours after fertilization - Nature Communications Reliable assessments of oocyte developmental potential are lacking, making it difficult to select the best quality embryos for transfer after in vitrofertilization. Here, the authors show that a non-i...

There has been important studies suggesting biomechanical properties of oocytes can predict blastocyst development #ESHREjc

www.nature.com/articles/nco... Human oocyte developmental potential is predicted by mechanical properties within hours after fertilization | Nature Communications

Much evidence comes from those models…. Is it time to shift? #ESHREjc

[out of topic, if you are curious ➡️ acd.od.nih.gov/documents/pr...

Q1. How do the structural components of the oocyte cortex (e.g., actin, myosin-!, pERM, Arp2/3, Fyn kinases) dynamically remodel during the transitions from GV to MIl and how do these changes mechanistically support spindle positioning and polar body extrusion? #ESHREjc

The effects of cortical dysregulation in embryo development are discussed in the 2nd question of the #ESHREjc 👇🏻

Fyn-null oocytes have problems in maintaining cortical integrity....they are subfertile #ESHREjc

Q2: The paper proposed that cortical dysregulation can lead to blastomeri fragmentation and reduced blastocyst quality. What are the proposed mechanisms by which ectopic chromosomal signaling or cortical instability leads to abnormal cleavage patterns in early embryos? #ESHREjc

@gliperis.bsky.social advice pls🙏🏻#ESHREjc

Great point. The shift to a polarized cortex shows how cytoskeletal remodeling drives spindle positioning, enabling migration and asymmetric cytokinesis through spatially restricted contractility. #ESHREjc

Arp2/3-driven actin is also crucial for cortical plasticity, while myosin-II provides the tension needed for polar body extrusion. Could this difference in roles explain why actin perturbations and myosin inhibition produce distinct maturation phenotypes? #ESHREjc