Eva Estébanez-Perpiñá, Ph.D.

How fast does a protein fold? Real-time technique captures the moment Proteins assume complex 3D shapes even faster than does DNA, which is a simpler molecule.

Scientists say they have made some of the first direct measurements of how long it takes an individual, ordinary protein to fold – and the results were surprising.

go.nature.com/3N4UrSD

🎯 Our team is honoured to participate in the workshop on Rare Diseases at the @biologiaub.bsky.social showing our research done at @ibub-ub.bsky.social on the molecular mechanisms of rare syndromes Androgen Insensitivity and Chrousos generalized glucocorticoid resistance 🧩📌

Native chromatome profiling reveals hundreds of metabolic enzymes in the nucleus across tissues - Nature Communications Here proteomic chromatome analysis shows metabolic enzymes widely localize to chromatin in cancer in a tissue-specific manner. Nuclear enzymes affect DNA damage/repair and transcription, revealing non...

New paper out in Nature Communications:
www.nature.com/articles/s41...
We found >250 metabolic enzymes on chromatin.
Only ~20 had been reported before.
This means hundreds of metabolic enzymes may have unexplored nuclear roles.

🔬 Recerca UB | IV Jornada sobre Recerca en Malalties Rares. Una iniciativa de la Càtedra @ub.edu en Malalties Rares per compartir avenços en recerca.

📅 05/03
⏰ 09:00
📍 Aula Magna Ramon Parés, Facultat de Biologia

Acte obert a tot el públic

🔗 Més informació a https://f.mtr.cool/onjapobfyu

Acute NIPBL depletion reveals in vivo dynamics of loop extrusion and its role in transcription activation - Nature Genetics Acute depletion of NIPBL reveals a class of chromatin loops that are independent of NIPBL for their maintenance but not their establishment and that NIPBL is necessary for the expression of lineage-de...

Very excited to share my postdoc research in the @jesserdixon.bsky.social lab at @salkinstitute.bsky.social, out online at @natgenet.nature.com today! www.nature.com/articles/s41... We investigated the function of the cohesin accessory protein NIPBL, making two particularly interesting findings:

📢 Read our new bioRx in colab with Gordon Hager NIH @PabloFuentesP #FRecio @aguslafuent @PresmanLab @WaghKaustubh #IGoldstein et al where we found glucocorticoid receptor GR self-assembly, chromatin binding & activity is modulated by bile acids binding to a novel druggable site

🎯 We are so thrilled our new paper @narjournal.bsky.social is out! Fantastic collab with the labs of Gordon Hager NIH & Franck Dequiedt. Heaviest lifting from Greg Fettweiss, Kaustub Wagh, Diana Stavreva & Alba Jiménez-Panizo. Big thanks to Andrea Alegre-Marti JdC 🥳✨️
academic.oup.com/nar/article/...

Check out our new findings showing BRD4's role in preventing the premature activation of developmental transcription factors via #Polycomb, providing new mechanistic insights into the pathogenesis of neurodevelopmental disorder #CdLS #NDDs, #chromatinopathies www.biorxiv.org/content/10.6...

Allosteric Induction of Estrogen Receptor Ligand Binding Domain Tetramerization by a Distinct Complete Estrogen Receptor Antagonist Complete estrogen receptor antagonists (CERANs) are effective against advanced estrogen receptor-positive (ER+) breast cancers, but current chemical scaffolds limit our ability to explore the full ran...

Latest publication from our lab! A part of our ongoing efforts to identify estrogen receptor ligands that influence structural and oligomeric states in unique ways. pubs.acs.org/doi/10.1021/...

AlphaFold protein interaction modeling tutorial and workshop - the Node This video is the culmination of several years attempting to: (1) Figure out best practices for modeling protein-protein interactions; (2) Understand the This video is the culmination of several years...

AlphaFold protein interaction modeling tutorial and workshop thenode.biologists.com/https-www-yo...

Our new review, looking into the roles of SWI/SNF in the chromatin environment around centromeres, is just out in Open Biology! @kezlane.bsky.social @thedownslab.bsky.social

An interactive resource mapping the proteome and reactive cysteine landscape across the NCI-60 reveals cell and tissue-specific profiles Montaño et al. generate an integrated proteomic and cysteine reactivity resource for the NCI-60 cancer cell line panel, offering quantitative data on over 12,000 proteins and 36,000 cysteines to enable future studies on protein function, cysteine biology, and covalent drug discovery.

Online now! Online now! An interactive resource mapping the proteome and reactive cysteine landscape across the NCI-60 reveals cell and tissue-specific profiles #chembiol

Ninhydrin as a covalent warhead for chemical proteomic-enabled discovery and selective engagement of reactive arginines Covalent molecules have emerged as next-generation therapeutics and as powerful tools for perturbing fundamental biological processes. Chemical proteomic methods to screen for reactive proteinaceous a...

Is arginine the new cysteine?! Check out our lab's latest in collaboration with @ianseiple.bsky.social's team where we introduce ninhydrin as a selective covalent warhead and probe targeting reactive arginines.
www.biorxiv.org/content/10.6...

Does a cell’s gene expression always reflect its function? Transcriptionally similar neurons can be functionally diverse.

Evidence suggests that transcriptionally similar cells can be functionally diverse

go.nature.com/3N4lT2d

We look very much forward to keeping doing Science together in 2026! ✨️🎄🚀🪐
Stay tunned 🪇
@ibub-ub.bsky.social @bqbiomedmolub.bsky.social @ub.edu

#ArticleOfTheMonth I November 2025
✒️The multimerization pathway of the glucocorticoid receptor

🔗Access the full article here 👉 www.biorxiv.org/content/10.1...

@ub.edu @biologiaub.bsky.social @farmaciaub.bsky.social @www.pcb.ub.edu @estebanezlab.bsky.social

Researchers decipher a mechanism that determines the complexity of the glucocorticoid receptor

🎯 Researchers decipher a mechanism that determines the complexity of the glucocorticoid receptor - Current events - University of Barcelona web.ub.edu/en/web/actua...

Researchers decipher a mechanism that determines the complexity of the glucocorticoid receptor

(1/4) Congrats @estebanezlab.bsky.social & team for your new paper deciphering the mechanism determining #GlucocorticoidReceptor complex @bqbiomedmolub.bsky.social @biologiaub.bsky.social

web.ub.edu/en/web/actua...

#PCBCommunity |🔬 L'@ibub-ub.bsky.social
@bqbiomedmolub.bsky.social @biologiaub.bsky.social desxifra el mecanisme de multimerització del receptor de #glucocorticoides (GR), obrint una via crucial per desenvolupar #fàrmacs més selectius capaços de minimitzar efectes adversos greus.

👉 tuit.cat/eDIgJ

Thanks Jens! 🙏🥳✨️

Desxifrat el mecanisme que determina la complexitat del receptor de glucocorticoides

🔊Nova recerca al dpt @bqbiomedmolub.bsky.social pel grup @estebanezlab.bsky.social @ibub-ub.bsky.social @biologiaub.bsky.social‼️
Desxifrat el mecanisme que determina la complexitat del receptor de glucocorticoides - Actualitat - Universitat de Barcelona web.ub.edu/ca/web/actua...

Researchers decipher a mechanism that determines the complexity of the glucocorticoid receptor

🎯 Researchers decipher a mechanism that determines the complexity of the glucocorticoid receptor - Current events - University of Barcelona web.ub.edu/en/web/actua...

The multimerization pathway of the glucocorticoid receptor Abstract. The glucocorticoid receptor (GR) is a leading drug target due to its antiinflammatory and immunosuppressive roles. The functional oligomeric conf

The multimerization pathway of the glucocorticoid receptor url: academic.oup.com/nar/article/...

Happy to share the latest publication led by Pablo Fuentes-Prior, G. Hager, and @estebanezlab.bsky.social, with talented co-first authors Andrea, Alba, and Agustina.

This one feels special to me, as I explain in this thread below....

Congrats Núria Jaime and rest of the team! 🥂

Thanks so much! 🙏✨️

🎯 With absolut joy we share our newest #NucleicAcidsResearch on Glucocorticoid Receptor Multimerization. Enormous team work by Pablo Fuentes, Gordon Hager, Alba Jiménez, Andrea Alegre, Agustina Lafuente, Tom Johnson Nuria Peralta, Diego Presman, JRecio, Jaime Rubio, Pilar Montanyà, Josep Ponsetí 🥳🚀

🔊 Nova publicació del Dpt @bqbiomedmolub.bsky.social pel grup liderat per la Dra Eva Estébanez-Perpiñá ‪@estebanezlab.bsky.social ‬@ibub-ub.bsky.social @biologiaub.bsky.social
Enhorabona! 👋👋

Gràcies! 🙏🥳🚀