Ashrafi Lab

Huge thanks to our collaborators Vitaly Klyachko and Gabor Egervari. And of course, Marion Stunault who led this work!

Ketogenic diet dampens excitatory neurotransmission by shrinking synaptic vesicle pools Stunault et al. show that the ketogenic diet drives extensive transcriptional reprogramming of the hippocampus through histone post-translational modifications, leading to altered short-term plasticit...

Ever wondered why ketogenic diets protect against epilepsies? We found profound synaptic remodeling that alters integration of excitatory and inhibitory inputs in the hippocampus and may thus be seizure-protective: www.cell.com/cell-reports...

I took my daughter to a doctor in the US and she introduced herself as Palestanian. All I could feel was immense shame that here she is treating our sick kids while we let their kids starve!

Although this is a professional account, I want to express my extreme sadness and despair for my country #Iran who is embroiled in a brutal war. My greatest hope is that we find the humanity in us to prevent it from turning into another Gaza.

good to witness leadership once in a while.

Harvard stands up.
www.harvard.edu/research-fun...

congratulations!

does this mean NIH grants? 😨

people culturing primary neurons, where do you get your FBS?

Thank you Natalie!

Thank you! your paper helped us a lot actually!

we are excited to join the community by sharing latest story from the lab where we show that mitochondrial pyruvate uptake is a critical step ATP production in hippocampal terminals and regulated by lysine acetylation of MPC. www.science.org/doi/full/10....