Taryn Beckman

I am excited to share my publication in collaboration with @lisarvolpatti.bsky.social! We found that a novel engineered prodrug allows systemic circulation of Butyrate, slowing atherosclerosis disease progression through immune and metabolic mechanisms.

insight.jci.org/articles/vie...

An atlas of metabolites driving chemotaxis in prokaryotes - Nature Communications In this meta-analysis, the authors compile results from 60 years of chemotaxis research into a database of prokaryotic chemoeffectors that compares and analyses their effects as attractant, repellent or neutral compounds, as well as the chemotactic behaviour of responding microorganisms.

An atlas of metabolites driving chemotaxis in prokaryotes

This database compiles the effects (attractant, repellent or neutral) of 926 compounds and the chemotactic behaviour of 394 strains

#ChemicalBiology #Microbiology

Activation of lysosomal iron triggers ferroptosis in cancer - Nature Some cancer cells exhibit high loads of reactive iron in lysosomes, and this feature is exploited by using fentomycin-1, a newly developed small molecule, to induce ferroptosis.

Nature research paper: Activation of lysosomal iron triggers ferroptosis in cancer

https://go.nature.com/4jO9ZVX

Multiomics reveal key inflammatory drivers of severe obesity: IL4R, LILRA5, and OSM
www.cell.com/cell-genomic...

Removal of toxic steroidal glycoalkaloids and bitterness in tomato is controlled by a complex epigenetic and genetic network A complex regulatory network controls the removal of toxic steroidal glycoalkaloids during tomato ripening.

Tomatoes lose their bitterness and toxicity as they ripen thanks to DNA demethylation, the hormone ethylene, and key transcription factors, finds a new #ScienceAdvances study. scim.ag/4bfdr8u

sequencing.roche.com/global/en/ar...

Really cool stuff by Roche! Sequencing by Expansion Nanopore Sequencing!

www.biorxiv.org/content/10.1...

Trump’s siege of science: how the first 30 days unfolded and what’s next The breakneck pace and devastating impact of the administration’s policy changes has shocked researchers.

Trump’s siege of science: how the first 30 days unfolded & what’s next

Once upon a time leaders believed that science was essential to nation’s security, to better health, to more jobs, to a higher standard of living & to cultural progress
🧪 #academicSky
@nature.com
www.nature.com/articles/d41...

Rhodoquinone carries electrons in the mammalian electron transport chain Valeros et al. identify rhodoquinone (RQ), an electron carrier present in mammalian mitochondria, that can deliver electrons to fumarate instead of O2 as the terminal electron acceptor. The authors de...

🧪Thrilled to share the latest research from the lab of my awesome @umasschan.bsky.social colleague Jessica Spinelli (who isn't on here yet) and collaborators:
www.cell.com/cell/fulltex...