Henne lab

Lipid scrambling: New players, new questions, new opportunities Nearly a quarter of the proteins encoded in most organisms are transmembrane proteins. Contrary to textbook description, many feature a hydrophilic gr…

Amazing PhD @cristianrocharoa.bsky.social
and I have collected our thoughts and questions (many!) on lipid scramblases in this review:
www.sciencedirect.com/science/arti...
If you are interested in lipid transport and metabolism, membrane asymmetry and membrane protein function, give it a read!

Please share!!! I am looking for a postdoctoral researcher to join us. Focus will be on exciting collaborative projects on lipids and membrane biology, pushing the boundaries of in silico "reconstitutions". Previous experience with molecular dynamics simulations of biological systems a strong plus!

and Yoni! : )

It was so wonderful working with you on this! : )

Heterogeneity, dynamics and organelle interactions of lipid droplets - Nature Reviews Molecular Cell Biology Lipid droplets have key roles in energy storage and lipid metabolism. This Review discusses tools used for assessing lipid droplet heterogeneity, and how their heterogeneous composition and interactio...

With so many great reviews on LDs already out, do we need another?

Sarah @cohenlaboratory.bsky.social and I were approached by
@natrevmcb.nature.com to do a review on LD heterogeneity and inter-organelle contacts...topics in reviews, but not a focus. Fun project!
www.nature.com/articles/s41...

I've been waiting for this Titeca et al. story from Anne-Claude Gavin's lab to come out: A systematic, comprehensive analysis of lipid transfer protein cargo selection, a truly massive undertaking. What a time to work in lipid biology. Cool stuff every few days.
www.nature.com/articles/s41...

Membrane editing with proximity labeling reveals regulators of lipid homeostasis - Nature Chemical Biology Coupling an optogenetic lipid-modifying enzyme with proximity labeling reveals protein networks and mechanisms regulating lipid homeostasis in the membranes of target organelles.

Thrilled to share our latest study, led by @reikatei.bsky.social, in @natchembio.nature.com! We began by asking a simple question—how do cells know if they have too much of a lipid in a particular membrane, and how do they respond to rectify this imbalance?
www.nature.com/articles/s41...
More info 👇

Registration is open for the FASEB #LipidDroplet meeting in Scottsdale, July 26-30! This is THE premier North American conference on LDs, you do not want to miss it!

Interested in lipids? Join us @ the 2026 FASEB Lipid Droplet: From Mechanisms to Disease Conference (July 26-30, Scottsdale, AZ). Registration is now open!

events.faseb.org/event/Lipid-...

We are co-locating with the FASEB Phospholipids SRC! Register for one to enjoy BOTH meetings!

Congrats Claudia! Very nice work!

💥I am excited to present our first research paper from the lab about caveolae lipid trafficking 🎉 Led by my fantastic PhD candidate @estherocket.bsky.social

Here we looked into caveolae mediated dietary lipid uptake and how this process is mechanistically facilitated 👇 1/n

Attending #CellBio2025? Come see the Cohen Lab - Monday will be a busy day for us, including my theatrical debut in WICB "Scripts of Success" skits!

ATG2A-mediated DAG transfer recruits DGAT2 for lipid droplet growth - Nature Structural & Molecular Biology Elhan et al. show that ATG2A acts with DGAT2, the enzyme producing triacylglycerol (TAG), in lipid droplet growth. By delivering diacylglycerol to lipid droplets, ATG2A not only fuels TAG production b...

Thrilled to share our latest work showing that the bridge lipid transport protein ATG2A transfers diacylglycerol (DAG), and some TAG/PA, from the ER to LDs, thereby recruiting DGAT2 to drive local TAG synthesis, promoting LD expansion while protecting ER membranes.
www.nature.com/articles/s41...

Check out our @ascbiology.bsky.social #CellBio2025 Minisymposium on ER Homeostasis. With THIS speaker lineup, this event will be as dynamic, transformative and productive as the ER itself!
So don’t 𝗦𝗧𝗥𝗘𝗦𝗦, 𝙩𝙧𝙖𝙣𝙨𝙡𝙤𝙘𝙖𝙩𝙚 yourselves over and join us to 𝗡𝗘𝗧𝗪𝗢𝗥𝗞 in world of the ER. (All PUNS intended.)

The Myo2 adaptor Ldm1 and its receptor Ldo16 mediate actin-dependent lipid droplet motility Zhao et al. identify the molecular machinery for lipid droplet motility, consisting of the type V myosin Myo2, the Myo2 adaptor protein Ldm1, and its surface receptor Ldo16. They uncover a molecular l...

Proud to share our study on #LipidDroplet #Motility #Mitochondria #MembraneContactSite now in Cell Reports @cp-cellreports.bsky.social! Big thanks to @rwedlichsoldner.bsky.social, @flofroehlich.bsky.social, @ruferbus.bsky.social, Daniel Kümmel lab, Thomas Becker lab! www.cell.com/cell-reports...

Congratulations!

Lipid droplet growth is orchestrated by the seipin complex, which provides a structural platform for droplet nucleation and expansion. The microprotein adipogenin fine-tunes seipin’s conformation, remodeling its architecture to regulate lipid storage capacity. This modulation results in the formation of fewer but larger lipid droplets, revealing a key mechanism in lipid homeostasis.

Fat storage in the body relies on specialized structures called lipid droplets. In a new Science study, researchers identified the microprotein adipogenin as a regulator of adipocyte lipid droplet size, revealing a key mechanism in lipid homeostasis.

Learn more this week: https://scim.ag/4nFEGO7

Adipogenin promotes the development of lipid droplets by binding a dodecameric seipin complex The microprotein adipogenin (Adig) is predominantly expressed in adipose tissues. Here, we found that Adig interacts with seipin to form a stable, rigid complex. We present the structure of the seipin...

New paper in Science identifying adipogenin as a critical seipin regulator in LD biogenesis. So glad our lab could help a little in this monumental study. Congrats to all authors!

www.science.org/doi/10.1126/...

Happy Halloween from the Henne lab!

FSP1-mediated lipid droplet quality control prevents neutral lipid peroxidation and ferroptosis - Nature Cell Biology Lange et al. identify a lipid droplet quality control pathway in which FSP1 safeguards stored neutral lipids from lipid peroxidation, thereby preventing the induction of ferroptosis.

Excited to share our study out in @natcellbio.nature.com! Led by @mikelangelipid.bsky.social, we identify the first #LipidDroplet lipid quality control pathway: LD-localized FSP1 protects stored lipids from oxidative damage and prevents LD-initiated #ferroptosis.
www.nature.com/articles/s41...

Looking forward to #UNCResearchWeek! I'll be presenting my lab's work on #organelles in physiology and neurodegenerative disease on Monday, October 20

Lol...all that crossed the road. ; )

Great Endoplasmic Reticulum meeting in Paris organized by the amazing Eric Chevet @ericchevet.bsky.social! It was wonderful to also hang out with James Olzmann @olzmannlab.bsky.social and Rachid Thiam @abdourachidthiam.bsky.social.

Thanks Ilya! Great meeting and great folks.

Another great EMBO #LipidDroplets workshop in Sant Feliu de Guixols! Many thanks to Maria Bohnert, Robin Klemm, and Bianca Schrul for the wonderful organization!

Fred Hutchinson Cancer Center Fred Hutch is dedicated to the elimination of cancer and related diseases as causes of human suffering and death.

My awesome Drosophila colleague Akhila Rajan at Fred Hutch (Seattle) is recruiting both a staff scientist and a postdoc to study fat–brain communication, innate immunity, mitochondrial signaling, and brain senescence. Great team, great environment. Apply here: careers-fhcrc.icims.com/jobs/30062/j...

Congrats Sarah!

Wonderful to see our paper on the #organelle signatures of #neurons and #astrocytes out in final form - congratulations, Shannon Rhoads and team!🎉 t.co/BPxKlbU6Ou

A pleasure to write this short review on lipid droplets for
@jcb.org together with Will Prinz and amazing artist Emma Reynolds!

We discuss 5 pervasive questions surrounding these remarkable little lipid organelles.

doi.org/10.1083/jcb....

Great department! Most departments at UT Southwestern are actively or will soon be actively recruiting new PIs. Please consider joining us!