Van Nguyen-Dinh DVM. PhD.

Molecular basis of influenza ribonucleoprotein complex assembly and processive RNA synthesis Influenza viruses replicate and transcribe their genome in the context of a conserved ribonucleoprotein (RNP) complex. By integrating cryo–electron microscopy single-particle analysis and cryo–electro...

Excited to share our new @science.org paper! Led by postdocs Ruchao Peng and Xin Xu, we used cryo-EM/ET to reveal the influenza ribonucleoprotein complex structure and its strand-sliding mechanism for RNA synthesis, paving the way for new antivirals.
www.science.org/doi/10.1126/...

eft: A 2D CryoSXT projection of an HSV-1 evelopment event. Right: A 3D rendering of the budding assembly stage captured by CLXT.

A new combination of microscopy methods has revealed exquisite detail of the virus assembly process used by herpes simplex virus during replication.
buff.ly/43aqR3G

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A conserved class of viral RNA structures regulates translation reinitiation through dynamic ribosome interactions Certain viruses with bicistronic mRNAs use reinitiation to translate the downstream open reading frame. Sherlock et al. use bioinformatics to find new examples of RNA structures that mediate reinitiat...

Viral RNA structures that dynamically interact with ribosomes to initiate translation

www.cell.com/cell-reports...

Merry Christmas! 🎄🎅☃️🎁

Molecular sociology of virus-induced cellular condensates supporting reovirus assembly and replication - Nature Communications Virus-induced cellular condensates are poorly understood. Using cryoET and cryoEM, the authors visualized the 3D “molecular sociology” of host-virus interactions and choreographed mammalian reovirus a...

Excited to share our new work! We shed light on the sociology of virus-induced condensates supporting reovirus assembly and replication. Visualized using #CryoET #CryoEM and #FIBmilling

www.nature.com/articles/s41...

Great collab w/ @xianxia13 @zhou_lab Xiaoyu Liu @gonenlab

🥳New cryo tomography Preprint ☀️🌱🔬Molecular architecture of thylakoid membranes within intact spinach chloroplasts.

doi.org/10.1101/2024.1…
Proud to be part of this great work with
@cellarchlab.com
@wojwie.bsky.social
@sheffieldpps.bsky.social

Here is a starter pack for CryoEM/ET enthousiasts
To be completed
go.bsky.app/JmQksC

Here is part 2 of the list. go.bsky.app/TWLffWH

A starter pack for all virologists out there on the blue side ! Might be missing some people but it’s a good start ! go.bsky.app/DmphBCT

⚠️THREAD OF ALL SCIENCE-RELATED STARTER PACKS! ⚠️

🔄Share to help people finding its topic/field

- STRUCTURAL BIOLOGY

Structural Biology 1: bsky.app/starter-pack...
Structural Biology 2: bsky.app/starter-pack...
Crystallography: bsky.app/starter-pack...
Synchrotron&CryoEM: bsky.app/starter-pack...