A man wearing a blue shirt stands in a hallway, with walls and floor visible in the background.
We're proud to announce that infectious disease pioneer Jean-Laurent Casanova, MD, PhD, of @rockefeller.edu, @institutimagine.bsky.social, @hhmi-science.bsky.social, & @casanovalab.bsky.social, is the recipient of the 2026 Mechthild Esser #NemmersPrize in Medical Science: spr.ly/6008hCUaM
Indeed, we screen all severe cocci patients referred to UCLA (rare, yes ~ 2/month) for their Th2 ratio before starting dupilumab. As you'll see in an upcoming JCI Insight paper (!) we defined a threshold Th2/Th1 ratio of >1.27 as a useful cutoff for treatment. It's personalized therapy, indeed!
New paper out in Nature Communications:
www.nature.com/articles/s41...
We found >250 metabolic enzymes on chromatin.
Only ~20 had been reported before.
This means hundreds of metabolic enzymes may have unexplored nuclear roles.
Toward the end of his two-volume Treatise on the Venom of the Viper, published in 1781, the Tuscan naturalist Deluxe Fontana declared: "I have made more than 6000 experiments; I have had more than 4000 animals bit; I have employed upwards of 3000 vipers and may have been deceived; some essential circumstance may have escaped me: I may have neglected some other, not thinking it necessary; my consequences may have been too general, my experiments too few in number. In a word, I may very easily have been mistaken, and it would be almost impossible that I should never have been so in a matter so difficult, so obscure, and likewise so new."
Fontana thinking his 6000+ experiments may not have been enough to feel confident in his conclusions in the 18th century while we expect our singular experiments and their standalone replications to do wonders some 250 years later... (excerpt from the intro of Jutta Schickore's About Experiment)
Hey the guy that makes the deepfake generator and suicide machine is gonna get into the murderbot business sounds great what could go wrong
These results suggest that initial exposure to Xβs algorithm has persistent effects on usersβ current political attitudes and account-following behaviour, even in the absence of a detectable effect on partisanship.
Donβt follow conservative political activist, those posting every incidence of crime
Something that probably you already know, but on Nature:
www.nature.com/articles/s41...
Cartoon by Mike Luckovich.
This sort of thing is why people are understandably not coming to the US. I would be really surprised if the expected international crowds arrive for the World Cup, at least at the US venues. Maybe some diehard fans will come. But the risk is just too great.
I am sorry but this is still the core problem with trying to parse anything he says about tariffs.
Vedi figlio mio, se ti impegni e lavori duramente, alla fine, nella vita, vedrai che-
sigh
Our paper is out in @natneuro.nature.com!
www.nature.com/articles/s41...
We develop a geometric theory of how neural populations support generalization across many tasks.
@zuckermanbrain.bsky.social
@flatironinstitute.org
@kempnerinstitute.bsky.social
1/14
New article to read! Myasthenia gravis following the initiation of statin therapy.
β‘οΈ Statin initiation may be associated with increased risk of new-onset MG during the first 6β12 months.
π doi.org/10.1111/joim.70072
#MyastheniaGravis #MG #statins
The immune systems paradox
Some widespread prokaryotic immune systems are absent in eukaryotes, whereas relatively rare ones became central to eukaryotic innate immunity
@audeber.bsky.social & E. Koonin hypothesize the answer is #HGT
shareable link: rdcu.be/e2EmD
www.nature.com/articles/s41...
Expansion microscopy may be the hi-res hero that many biologists have been craving.
"There are several possible reasons for this unsettling state of affairs" www.nature.com/articles/s41...
The actual US government should be stopped. I mean, all of this isn't sufficient for an impeachment?
A very nice review on type I IFN autoantibodies:
www.sciencedirect.com/science/arti...
The IL17REL gene encodes a decoy receptor of IL-17 family cytokines to control gut inflammation
Qi Li et al. π§ͺ
www.nature.com/articles/s41...
Pancreatic cancer is the third deadliest cancer. Treatment often fail due to resistance.
A new study in PNAS led by Mariano Barbacid tackles this with a triple combination therapy that induces robust tumor regression and prevents the onset of tumor resistance in mice.
#SciSky #MedSky #Oncology
I'm so sorry for your loss. And also, for this f*ckin authocratic crazy regime in USA. Remember what happened in Italy with blackshirts
Alex Pretti was a colleague at the VA. We hired him to recruit for our trial. He became an ICU nurse- I lover working with him. He was a good kind person who lived to help and these fuckers executed him.
White. Hot. Rage.
Increased prevalence of #autoantibodies neutralizing IFNΞ»2/3 in young individuals with #CysticFibrosis. New report from Kevin Groen, Emanuela Bruscia, Marc Emmenegger, Benjamin Hale @benhale.bsky.social and colleagues: rupress.org/jhi/article/...
#Autoimmunity #Infections
Not sure this counts as a timeline cleanse but check out the weird little cars I made
It's AI colonialism
Human genetics guides the discovery of CARD9 inhibitors with anti-inflammatory activity @cellcellpress.bsky.social @thexavierlab.bsky.social @broadinstitute.org
www.cell.com/cell/fulltex...
The main bank account holding revenue from the Venezuelan oil sales is located in Qatar.
βThere is no basis in law for a president to set up an offshore account that he controls so that he can sell assets seized by the American military,β Sen. Elizabeth Warren.
www.semafor.com/article/01/1...
It's me
www.nature.com/articles/s41...
π CD19 CAR-T cells for treatment-refractory autoimmune diseases: the phase 1/2 CASTLE basket trial
βCASTLE suggests the feasibility, safety and efficacy of Zorpo-cel in three different autoimmune diseases and paves the way for conducting a pivotal study.β
#SLE #CART
