Elodie Monsellier, PhD

Mapping the yeast atructural interactome with AlphaFold3: an open call for collaboration We are excited to announce the early-stage release of our S. cerevisiae  structural interactome mapping project. Using AlphaFold3 (AF3), w...

We have started a project trying to predic the interactions/structures of all yeast protein pairs using an AlphaFold pooling approach. We are making the current dataset open and we welcome collaborations.
www.evocellnet.com/2026/03/mapp...

A big thank you to @intact-ebi.bsky.social for the great collaboration integrating our high-throughput binding affinity (Kd) measurements into their database! Check out the kind of data we can generate using the Holdup assay — and there’s much more to come!

The FMI cryo-EM team is looking for a new team member. Join us in Basel!

Et le sourire ! Parce que évidemment il faut être contente et reconnaissante d'être là

Et le sourire !! Parce que évidemment il faut être contente et reconnaissante d'être là

Couverture du magazine "L'actualité Chimiqueé de nov-dec. 2025 représentant une sorte de gloubi boulga bleu rose évoquant l'ADN et produit par l'outil d'IA Venngage (c'est mentionné dans le sommaire)

Après des années de chroniques climatosceptiques, l'Actualité Chimique nous offre une couverture full IAgen qui fera saigner les yeux des collègues bossant sur les acides nucléiques.
Une publication décidément à la pointe sur les enjeux de société...

Our community Meet the award-winners and projects leaders supported by the Foundation, full_html

Many congrats @teamgogl.bsky.social @camilleberthelot.bsky.social for the 2025 Impulse and @abdourachidthiam.bsky.social for the 2025 Liliane Bettencourt Prize for Life Sciences

www.fondationbs.org/en/our-commu...

Why IDPs Are Poor Candidates for Homotypic LLPS

🧵👇A thread

New preprint! We measured temperature- and pH-induced aggregation for over 18,000 natural and de novo designed protein domains!

Our new special collection "Protein-Nucleic Acid Interactions: From Origins to Design (2025)" is now published in Current Opinion in Structural Biology. I'm excited to have both co-edited it with Shandar Ahmad and contributed a review!

www.sciencedirect.com/special-issu...

The IGBMC is recruiting a new Computational Biology Group Leader through the ENACT AI Chair for Scientific Discoveries, covering cancer, developmental, and structural biology. Join one of Europe’s leading life science centers!
cluster-ia-enact.ai/appels-a-pro...
Deadline: Jan 7, 2026

profaff.fr

The new ProfAff database is up and running. Although there are still many things to improve, it is a major upgrade.

🚨 1 week left to apply for the Pasteur-Paris University International PhD Program (PPU)!

Join an international community of scientists at the Institut Pasteur 🌍 Dedicated support, mentorship & world-class labs included.

📅Deadline: Oct 20, 2025
🎓Program start: October 2026

👉 Apply: bit.ly/CallPPU

🌟Ready to apply?
16 fully funded PhD positions are open in ProtAIomics Doctoral Network!
Join 16 labs across Europe to advance AI-powered proteomics and drive discoveries in health & biotechnology.
👉 Apply here: www.protaiomics.eu
#Proteomics #ArtificialIntelligence #MSCA #PhDOpportunities

Do you have an exciting experiment that you'd love to do using proteomics in the context of your work? YPIC funds 5000 eur for your research idea to come to life!

⬇️⬇️⬇️⬇️⬇️

Open PhD position in the Luck lab at IMB in Mainz, Germany, in the field of AI and computational structural biology. Check out project description here: www.imb.de/students-pos...
Funded as part of the European Training Network ProAIomics cordis.europa.eu/project/id/1...

🚨 We're hiring, please share! The FMI seeks a tenure-track Group Leader (Assistant Prof) in Structural Biology 🔬
Innovative scientists in genome regulation, RNA metabolism, or protein homeostasis—especially using cutting-edge approaches—apply now at www.fmi.ch/education-ca...

Affinity-ligand purification of native human low-abundance multi-protein complexes for structure determination In human cells, large multi-protein transcription co-activators, such as chromatin remodelers or histone acetyltransferases, play critical roles in gene-expression regulation and are often implicated ...

Check out our new collaborative preprint about Affinity-ligand purification of native human low-abundance multi-protein complexes doi.org/10.1101/2025...

#funfact il y a maintenant plus de signataires de la pétition contre la loi #duplomb (1.578.176 petitions.assemblee-nationale.fr/initiatives/...) qu'il y a eu de votants pour les LR au 2nd tour des législatives 2024 (1.474.650 www.archives-resultats-elections.interieur.gouv.fr/resultats/le...)

@cnrsecologie.bsky.social regrette profondément l'adoption de cette loi à la vision court-termiste & ses conséquences graves sur l’environnement, qui méprise santé & bien-être de la population & le rôle des espèces sauvages dans la prod. agricole. La communauté scientifique n'a pas été entendue.

Postdoctoral Scientist - Structural Studies - Dr Sjors Scheres - LMB 2640 - Cambridgeshire job with MRC Laboratory of Molecular Biology (LMB) | 12840844 Postdoctoral Scientist Starting Salary: £41,344 Fixed term: 3 years MRC Laboratory of Molecular Biology, Cambridge, UK We are looking for a postdoc...

We have a 3-year funded postdoc position to work on structures of #amyloid filaments. If you are an expert in protein biochemistry, structural biology or #cryoEM / #cryoET, this could be for you! Feel free to email me with any questions. Come join us! 🤩

www.nature.com/naturecareer...

KI to recruit junior researchers with a focus on excellence On 25 June, Karolinska Institutet will be starting a major recruitment drive for 20 junior researchers with a focus on excellence and mobility. As one of Europe’s leading medical universities, KI offe...

Save the date! On 25 June, Karolinska Institutet will be starting a major recruitment drive for 20 junior researchers with a focus on excellence and mobility news.ki.se/ki-to-recruit-junior-researchers-with-a-focus-on-excellence

The image is a creative sketch showcasing summaries of scientific presentations, visually represented with doodles, text, and portraits of speakers. The artist's Instagram handle, @isabellaease, is displayed.

You can now view #VariantEffect25 presentations from @pollyfordyce.bsky.social @davidjadams.bsky.social @nickywhiffin.bsky.social along with many many others! on our YouTube channel www.youtube.com/@cmap_cegs84... (hat tip to @isabellease.bsky.social for the excellent illustrations)

A 2-year postdoctoral position is available in the group "RNA Biogenesis, Architecture and Interactions," led by Carine Tisné at the Institut de Biologie Physico-Chimique (IBPC), Paris.

RNA modification landscape of V. cholerae

Great lab, great location & great PI

emploi.cnrs.fr/Offres/CDD/U...

#CoNRS #CNRS #ESR

Dépôt des candidatures pour les élections jusqu'au 16 avril. www.dgdr.cnrs.fr/elections/

N'hésitez pas à donner un peu de votre temps au service de la collectivité.

J'ai fait 9 ans de section, je n'en garde que des bons souvenirs. Une belle aventure scientifique et humaine !

Congratulations Bogi!!!

🚀 Big news! We've just published the official guidelines for submitting affinity proteomics data to PRIDE @pride-ebi.bsky.social (supported technologies Olink & SomaScan)!
Get ahead of the curve—check them out & start your submissions! 👇
🔗 github.com/PRIDE-Archiv...
#Proteomics #Olink #SomaScan

Congratulations Luke!

Holdup Multiplex Assay for High-Throughput Measurement of Protein–Ligand Affinity Constants Using a Mass Spectrometry Readout The accurate description and subsequent modeling of protein interactomes require quantification of their affinities at the proteome-wide scale. Here we develop and validate the Holdup Multiplex, a versatile assay with a mass spectrometry (MS) readout for profiling the affinities of a protein for large pools of peptides. The method can precisely quantify, in one single run, thousands of affinity constants over several orders of magnitude. The throughput, dynamic range, and sensitivity can be pushed to the performance limit of the MS readout. We applied the Holdup Multiplex to quantify in a few sample runs the affinities of the 14–3–3s, phosphoreader proteins highly abundant in humans, for 1000 different phosphopeptides. The seven human 14–3–3 isoforms were found to display similar specificities but staggered affinities, with 14–3–3γ being always the best binder and 14–3–3ε and σ being the weakest. Hundreds of new 14–3–3 binding sites were identified. We also identified dozens of 14–3–3 binding sites, some intervening in key signaling pathways, that were either stabilized or destabilized by the phytotoxin Fusicoccin-A. The results were corroborated by X-ray crystallography. Finally, we demonstrated the transferability of the Holdup Multiplex by quantifying the interactions of a PDZ domain for 5400 PBM peptides at once. The approach is applicable to any category of protein-binding ligands that can be quantifiable by mass spectrometry.

Holdup Multiplex Assay for High-Throughput Measurement of Protein-Ligand Affinity Constants Using a Mass Spectrometry Readout #JACS pubs.acs.org/doi/10.1021/...

Holdup Multiplex Assay for High-Throughput Measurement of Protein–Ligand Affinity Constants Using a Mass Spectrometry Readout pubs.acs.org/doi/10....

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#proteomics #prot-paper